Protein Alignment KCNS2 and kcnv2b

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: NP_001122212.1
• Gene: kcnv2b / 567780
• ZFINID: ZDB-GENE-060526-28
• Length: 527
• Species: Danio rerio
• Alignment Length: 480
• Identity: 165/480 - (34%)
• Similarity: 264/480 - (55%)
• Gaps: 33/480 - (6%)

Human     5 SLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREF 69
            :||..|.:...:..:.:||||...|:......|:|:||||||.:.......::|||||.....|:
Zfish    68 TLWFTSTSPSRNCTLNLNVGGKSYRITYKMAARYPQTRLGRLAMSTDLNMKMDLCDDYVVKDNEY 132

Human    70 YFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEK 134
            :|||:|::|..:.:||.||.|.:..|||..:|.:||.|||:...:...||....        :||
Zfish   133 FFDRDPDVFNSIFNFYRTGVLWIKDELCPRNFLEEISYWGVRIKYSQRCCRILL--------EEK 189

Human   135 WDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMG 199
            .||..:|.......:..|....:...||...||..||.||..::.|..|:.:::.::.|.:.|:.
Zfish   190 NDELCEQLKVQKELERELEIEENEEAFDDMILGESRRSLWDFMEKPFSSIPAKLMAVTSSMFVLI 254

Human   200 SIITMCLNSLPDFQIPDSQG-NPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLI 263
            |::||.|:::.:.:..:|:| |.|     |.||:..|.:||.|.:.|....||..:|||:.||.:
Zfish   255 SLVTMTLSTVEEMENIESEGKNYG-----EFVENLCITFFTIEYLLRVISTPDICRFFKSMLNAV 314

Human   264 DLMSIVPFYITLVV-----------NLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRS 317
            |||:|:|..:..::           :..:|:...:..:|:|.:::||:||||:|||||||||||:
Zfish   315 DLMAILPQILQFMLENFETFGSRNQSADMETVGQVGKVGQVLRIMRLLRIFRVLKLARHSTGLRA 379

Human   318 LGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKE-ENEGLATIPACWWWATVSMTTVGYGDVV 381
            .|.|||..|::||.|.|::::||..||.:.|::|.: ......:||..||||:||::||||||:.
Zfish   380 FGFTLKQCYQQVGCLFLFIAMGIFTFSAMVYSVEYDVPKTNFTSIPHSWWWASVSISTVGYGDMY 444

Human   382 PGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRD 446
            |.|..|::.|..||..||::..|||:::|||||.:|.:.|..|....       ||...:||...
Zfish   445 PETLLGRIFAFGCISFGIILNGLPISILFNKFSDYYAKLKSHECPSH-------MKNRGNVNFIP 502

Human   447 YYAHKVKSLMASLTNMSRSSPSELS 471
            ....|::......||...:..:.:|
Zfish   503 RAKKKLRECGCIETNDDTNDDTNVS 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	40/105 (38%)
		Ion_trans	186..421	CDD:459842	96/247 (39%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
kcnv2b	NP_001122212.1	BTB_POZ	82..189	CDD:453885	40/114 (35%)
		Ion_trans	241..484	CDD:459842	96/247 (39%)