Protein Alignment KCNS2 and kcnb2b

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_695259.4
• Gene: kcnb2b / 566883
• ZFINID: ZDB-GENE-091113-38
• Length: 831
• Species: Danio rerio
• Alignment Length: 487
• Identity: 198/487 - (40%)
• Similarity: 299/487 - (61%)
• Gaps: 28/487 - (5%)

Human     8 DVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFD 72
            ::.........:||||||....:...||.|.|.||||:|..|::.::::|:||||...:.|::||
Zfish    26 EIIRTKARSRRVRINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHDSLMEVCDDYCLNENEYFFD 90

Human    73 RNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDE 137
            |:|..|..:|:||.|||||:|.|:|..||.||::||||:|.:::|||...||.:|     |:.:|
Zfish    91 RHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK-----EQMNE 150

Human   138 QSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSII 202
            :..:|:      |.|.......:||.......|::||..|:.|..||.:::.:|:|||.::.|.:
Zfish   151 ELRREA------ETLREREGEGEFDNTCCPEKRKKLWELLEKPSSSVAAKILAIISILFIVLSTV 209

Human   203 TMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMS 267
            .:.||:||:.|:.|..|...::|:...||...|||||.|.:.||..:|:..||||..||:|||::
Zfish   210 ALSLNTLPELQVTDEFGQANDNPQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLA 274

Human   268 IVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLL 332
            |:|:|:|:.:....:|.....|:.||.|:.|:|||.||||||||||||:|||.||:.||.|:|||
Zfish   275 ILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLL 339

Human   333 LLYLSVGISIFSVVAYTIEKEEN-EGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACIL 396
            :|:|::||.|||.:.:..||:|: ....:|||.:||||::||||||||:.|.|..||:....|.:
Zfish   340 ILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLCCI 404

Human   397 AGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMK---EVPSVNLRDYYAHKV------ 452
            ||:||:.|||.:|.|.||.||:.||:.|.|::..:..:..|   .:.|:||:|.:|..:
Zfish   405 AGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELMDVT 469

Human   453 ------KSLMASLTNMSR-SSPSELSLNDSLR 477
                  |.|..:..:.|| ..|...|.:.|||
Zfish   470 VEKSDDKRLTDNHLSPSRWGIPQRTSSDTSLR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	50/105 (48%)
		Ion_trans	186..421	CDD:459842	112/235 (48%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
kcnb2b	XP_695259.4	BTB_POZ_KCNB2	19..145	CDD:349719	52/118 (44%)
		Ion_trans	193..429	CDD:459842	112/235 (48%)
		Kv2channel	480..706	CDD:397541	7/22 (32%)