DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KCNS2 and kcng4b

DIOPT Version :10

Sequence 1:NP_065748.1 Gene:KCNS2 / 3788 HGNCID:6301 Length:477 Species:Homo sapiens
Sequence 2:XP_009301775.1 Gene:kcng4b / 566228 ZFINID:ZDB-GENE-130530-634 Length:535 Species:Danio rerio


Alignment Length:423 Identity:158/423 - (37%)
Similarity:248/423 - (58%) Gaps:35/423 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    21 INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFY 85
            |||||.:......||..||.:|||:|..|.|.:.|.:||||||:.:|||:|||:...|..:|:|.
Zfish    64 INVGGDRYTFPWSTLDEFPLSRLGQLRHCSSPDDIAQLCDDYDEARREFFFDRSSVAFRVILNFL 128

Human    86 HTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSFDE 150
            ..|||.::.::|..|.|.|:.||||:...::.||......| ||...||..::.:::....:...
Zfish   129 AAGKLRLLRQVCAVSLSDELTYWGIDPVHMERCCRRKLLSR-VEDVAEKKKKEDERKQKRHALQR 192

Human   151 ILAFYNDASKFDGQPLGNFR--RQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQ 213
            .||          |..|..|  .:|...::||......::|:..|::::..::|::|:::|||. 
Zfish   193 PLA----------QDKGFIRLMNRLQEIVENPHSGWAGKLFACFSVVMIAVTVISLCISTLPDH- 246

Human   214 IPDSQGNPGEDPR-FEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVV 277
              :::|...|..| ..|||...:|||:.|.:.||..|...::|.:|.||:||:::|:|:||:|||
Zfish   247 --ENRGECTEKCRNIFIVETVCVAWFSMEFLLRFLQAESKMQFLRNPLNVIDVIAILPYYISLVV 309

Human   278 -----------NLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGL 331
                       |....|...|..||.:.:|:|.:||..:::|||||.||::||.|::.|.:|.||
Zfish   310 DSEDTSDEAELNGAGTSRGYLDKLGLILRVMRALRILYVMRLARHSLGLQTLGLTMQRSMREFGL 374

Human   332 LLLYLSVGISIFSVVAYTIEKEENEGLAT-------IPACWWWATVSMTTVGYGDVVPGTTAGKL 389
            |||:|.|.:::||.:.:..|||.::|.||       |||.:|||.:|||||||||:||.:..|::
Zfish   375 LLLFLCVAVALFSPLVHLAEKEFSKGKATGPNSFSSIPASYWWAIISMTTVGYGDMVPYSIPGQV 439

Human   390 TASACILAGILVVVLPITLIFNKFSHFYRRQKQ 422
            .|.:.||:|||::..|.|.||:.||..|...|:
Zfish   440 VAFSSILSGILIMAFPATSIFHVFSRSYHELKR 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNS2NP_065748.1 BTB_POZ_KCNS2 18..124 CDD:349734 44/102 (43%)
Ion_trans 186..421 CDD:459842 100/253 (40%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 4/4 (100%)
kcng4bXP_009301775.1 BTB_POZ_Kv6_KCNG 62..170 CDD:349691 45/106 (42%)
Ion_trans 221..471 CDD:459842 100/252 (40%)

Return to query results.
Submit another query.