Protein Alignment KCNS2 and kcng2

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_690900.2
• Gene: kcng2 / 562421
• ZFINID: ZDB-GENE-100701-1
• Length: 546
• Species: Danio rerio
• Alignment Length: 449
• Identity: 159/449 - (35%)
• Similarity: 260/449 - (57%)
• Gaps: 17/449 - (3%)

Human    11 EANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNP 75
            |.::.|....|||||.:.|:...||..||.||||||..|::.|.||:||||||....||:|||:|
Zfish    64 EGSLFDRTAIINVGGIRYRIPWSTLEEFPLTRLGRLHNCNNAEEILDLCDDYDARCNEFFFDRSP 128

Human    76 ELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEP-EQEKWDEQS 139
            ..|..::.|...|||.::.|:|..||.:|:.|||:.|..::.||......|:.|. |:.:.:|:.
Zfish   129 SAFRSIVTFLAAGKLRLLREMCALSFQEELSYWGVEEASLEWCCLRKLRLRQEEQRERLRLEEEE 193

Human   140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITM 204
            .:.::..|.:|..|.   .|..:|: |......|...::||...:..::|:.||::.|..:.:|:
Zfish   194 AELTSPHSCEEAPAV---GSPEEGR-LSGCMHSLRDMVENPHSGIPGKIFACLSVVFVAITAVTL 254

Human   205 CLNSLPDFQIPDSQGNPGED-PRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSI 268
            |::::||.:..:.:|...:. ....::|...:.||:.|.:.||........|.:..||:||:::|
Zfish   255 CVSTMPDLREEEERGECSQRCYNIFVLETVCVGWFSLEFLLRFIQTQSKCTFLRTPLNIIDVVAI 319

Human   269 VPFYITLVV-NLVVESTPT------LANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSY 326
            :|:||||:| ::.|...|.      |..:|.|.:|||.:|||.:::|||||.||::||.|::...
Zfish   320 LPYYITLIVDSMSVGDRPAGSGNNYLEKVGLVLRVLRALRIFYVMRLARHSLGLQTLGLTVRRCT 384

Human   327 KEVGLLLLYLSVGISIFSVVAYTIEKE--ENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKL 389
            :|.|||||:|.|.:::||.:.:..|.|  ..:...:||..:|||.:|||||||||:||.:..|::
Zfish   385 REFGLLLLFLCVAMALFSPLVFLAESELGAKQEFTSIPGSYWWAVISMTTVGYGDMVPRSIPGQV 449

Human   390 TASACILAGILVVVLPITLIFNKFSHFY--RRQKQLESAMRSCDFGDGMKEVPSVNLRD 446
            .|.:.||:|||::..|:|.||:.||..|  .:::|..:.....|..|..|...|.:.:|
Zfish   450 VALSSILSGILLMAFPVTSIFHTFSRSYLELKEEQNRATRHKPDSQDSTKSQNSEDSQD 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	48/105 (46%)
		Ion_trans	186..421	CDD:459842	90/246 (37%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
kcng2	XP_690900.2	BTB_POZ_KCNG1_2	68..175	CDD:349728	49/106 (46%)
		Ion_trans	237..481	CDD:459842	90/243 (37%)