DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNS2 and kcns3b

DIOPT Version :10

Sequence 1:NP_065748.1 Gene:KCNS2 / 3788 HGNCID:6301 Length:477 Species:Homo sapiens
Sequence 2:NP_001032460.1 Gene:kcns3b / 558674 ZFINID:ZDB-GENE-051120-78 Length:424 Species:Danio rerio


Alignment Length:420 Identity:195/420 - (46%)
Similarity:268/420 - (63%) Gaps:13/420 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    15 EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFP 79
            |:..:.:|:||...::....|||||.||:.:|:.|||..|||||||||...::|:||||:|::|.
Zfish    13 EEDLVNLNIGGIHHKVERCVLLRFPHTRVAQLIQCHSDAAILELCDDYSPTEQEYYFDRSPQVFH 77

Human    80 YVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQEST 144
            .||:||.||..|.:.|||||.|||||||||:.|..:|:||...:..||.|.|.    ..|.|.|.
Zfish    78 CVLNFYRTGHFHTLEELCVFCFSQEIEYWGLCELDLDACCLEWFLERKDEHEL----NSSGQSSK 138

Human   145 TSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSL 209
            .:|..||.....|..|.:|....:.|:.:|..|::|.:|..||..:.:|:||::.||:.||::||
Zfish   139 NASSGEISVTSEDLWKSEGMRCSDVRKLMWETLEDPQHSRCSRGVAAVSVLVILISILAMCVHSL 203

Human   210 PDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYIT 274
            |:|:..    ..||....:.||.|.|.:|:.|...|...||..|:|..|.||:||:.||:|||||
Zfish   204 PEFRYQ----TDGEHSVLDSVELFCIVFFSVEFFLRVIAAPQPLRFLGNPLNMIDVASILPFYIT 264

Human   275 LVVNLV----VESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLY 335
            |.|..:    .|...:|.|:|||.|||||||.||:|||||||.|:|:.|.||.....|||||:|:
Zfish   265 LAVERLDEEDKEENQSLVNMGRVVQVLRLMRSFRVLKLARHSEGMRAFGETLMNCQCEVGLLVLF 329

Human   336 LSVGISIFSVVAYTIEKEE-NEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGI 399
            ::||||.||...|..|||| :..|::||.||||..:||||||||||.|.|.||::.|:.|||.|:
Zfish   330 ITVGISFFSTFIYYTEKEEASSQLSSIPICWWWGIISMTTVGYGDVYPLTVAGRIVATVCILCGL 394

Human   400 LVVVLPITLIFNKFSHFYRRQKQLESAMRS 429
            ||:.||||:|.|.||.::.:.::..|..::
Zfish   395 LVISLPITIIMNNFSKYFEKNRKCLSEAKA 424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNS2NP_065748.1 BTB_POZ_KCNS2 18..124 CDD:349734 55/105 (52%)
Ion_trans 186..421 CDD:459842 120/239 (50%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 4/4 (100%)
kcns3bNP_001032460.1 BTB_POZ 15..117 CDD:453885 53/101 (52%)
Ion_trans 186..414 CDD:459842 118/231 (51%)

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