Protein Alignment KCNS2 and kcnb1

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_682848.4
• Gene: kcnb1 / 555284
• ZFINID: ZDB-GENE-090831-3
• Length: 834
• Species: Danio rerio
• Alignment Length: 458
• Identity: 192/458 - (41%)
• Similarity: 292/458 - (63%)
• Gaps: 17/458 - (3%)

Human    19 IRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLH 83
            :::||||....:...||.|.|.||||:|..|.:.|:::|:||||:....|::|||:|..|..:|:
Zfish    36 VKLNVGGLPHEVLWRTLDRLPRTRLGKLRDCKTHESLMEVCDDYNLEDNEYFFDRHPGAFTSILN 100

Human    84 FYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSF 148
            ||.|||||:|.|:|..|||||::|||::|.:::|||...||.:|     |:.:|:..:|:.|...
Zfish   101 FYRTGKLHMMEEMCALSFSQELDYWGVDEIYLESCCQARYHQKK-----EQMNEELKREADTLKD 160

Human   149 DEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSLPDFQ 213
            .|       ..:||.......|::||..|:.||.||.:::.:|:|||.::.|.|.:.||:||:.|
Zfish   161 RE-------GEEFDNTCCSEKRKKLWDLLEKPGSSVAAKILAIISILFIVLSTIALSLNTLPELQ 218

Human   214 IPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVN 278
            ..|..|...::.:...||...|||||.|.:.||..:|:..||||..||:|||::|:|:|:|:.:.
Zfish   219 ETDEFGQTTDNTQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLT 283

Human   279 LVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIF 343
            ...:|.....|:.||.|:.|:|||.||||||||||||:|||.||:.||.|:|||:|:|::||.||
Zfish   284 ESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIF 348

Human   344 SVVAYTIEKEENE-GLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPIT 407
            |.:.:..||:|:: ...:|||.:||||::||||||||:.|.|..||:....|.:||:||:.|||.
Zfish   349 SSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIP 413

Human   408 LIFNKFSHFYRRQKQLESAMRSCDFGDGMK---EVPSVNLRDYYAHKVKSL-MASLTNMSRSSPS 468
            :|.|.||.||:.||:.|.|::..:..:..|   .:.|:|:|:.::.....| :..:....||..:
Zfish   414 IIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNVREAFSRGTDLLDVVVMDKGERSQDN 478

Human   469 ELS 471
            .||
Zfish   479 HLS 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	49/104 (47%)
		Ion_trans	186..421	CDD:459842	112/235 (48%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
kcnb1	XP_682848.4	BTB_POZ_KCNB1	25..141	CDD:349718	49/104 (47%)
		Ion_trans	191..427	CDD:459842	112/235 (48%)
		Kv2channel	470..712	CDD:397541	4/12 (33%)