DRSC/TRiP Functional Genomics Resources

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Protein Alignment KCNS2 and kvs-4

DIOPT Version :10

Sequence 1:NP_065748.1 Gene:KCNS2 / 3788 HGNCID:6301 Length:477 Species:Homo sapiens
Sequence 2:NP_001367099.1 Gene:kvs-4 / 190011 WormBaseID:WBGene00012967 Length:539 Species:Caenorhabditis elegans


Alignment Length:418 Identity:138/418 - (33%)
Similarity:225/418 - (53%) Gaps:40/418 - (9%)


- Green bases have known domain annotations that are detailed below.


Human    11 EANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNP 75
            |..:.:..:::||||.:..||..|:.|   ..:||||...::.......|.:.....||||:|.|
 Worm   113 EEEISEQFVKLNVGGQRFMLRKDTIRR---RGVGRLLDLINKPVADSNADAFFSSTSEFYFERPP 174

Human    76 ELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGI--NEFFIDSCCSYSYHGRKVEPEQEKWDEQ 138
            .||..|..||..|.:|..:.||.....:|:|||.|  :::....||:     ::::.:.|:.:||
 Worm   175 SLFHIVYQFYLNGVIHQPSNLCPVDIIEELEYWRIIPDQYLASCCCA-----QQIDDDDEEVEEQ 234

Human   139 SDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIIT 203
                             :..:.|.....|..||.:|..::.|..|..::.|::.|::.|:.||..
 Worm   235 -----------------DKPNLFKTLRFGEIRRCVWNIIEEPASSGKAQAFAVCSVVFVLISISG 282

Human   204 MCLNSLPDFQIPDSQGN--PGED-------PRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNA 259
            :.|.|||:.|:...|.|  .||:       |....:|:..|.|||.|...:..|:.:..|.|:..
 Worm   283 LVLGSLPELQVATKQRNNLTGEEFTEMEPMPILGYIEYVCIVWFTMEYGLKMLVSAERSKTFRQL 347

Human   260 LNLIDLMSIVPFYITLVVNLVVESTPTLANLG---RVAQVLRLMRIFRILKLARHSTGLRSLGAT 321
            ||:|||::|:||.|.:::.:...||..|.:|.   .|.::||::|:.|:|||.|:|:||:..|.|
 Worm   348 LNIIDLLAILPFIIEMLLLIFGISTEQLRDLKGAFLVIRILRVLRVIRVLKLGRYSSGLQMFGKT 412

Human   322 LKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEG-LATIPACWWWATVSMTTVGYGDVVPGTT 385
            ||.|::::|::.:.:..|:..||.:.|.:||:|... ..:|||..||..|:||||||||:.|.|.
 Worm   413 LKASFRQLGMMAMVVMTGVIFFSTLVYFLEKDEPASKFHSIPAACWWCIVTMTTVGYGDLTPVTV 477

Human   386 AGKLTASACILAGILVVVLPITLIFNKF 413
            .|||.|:..|..|:||:.||||:|.:.|
 Worm   478 PGKLVATGAIACGVLVLALPITIIVDNF 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KCNS2NP_065748.1 BTB_POZ_KCNS2 18..124 CDD:349734 35/107 (33%)
Ion_trans 186..421 CDD:459842 92/241 (38%)
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 374..379 4/4 (100%)
kvs-4NP_001367099.1 BTB_POZ_Kv 121..208 CDD:349626 31/89 (35%)
Ion_trans 265..513 CDD:459842 92/241 (38%)

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