Protein Alignment KCNS2 and kcns2

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_073781759.1
• Gene: kcns2 / 141378117
• -ID: -
• Length: 464
• Species: Danio rerio
• Alignment Length: 462
• Identity: 292/462 - (63%)
• Similarity: 360/462 - (77%)
• Gaps: 6/462 - (1%)

Human    15 EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFP 79
            |:|.||||||||:|||.|..|.|||||||.|||.|..||:.||||||||:.:|||||||||.|||
Zfish     8 EEGAIRINVGGFRRRLLSDRLSRFPETRLARLLRCGCRESELELCDDYDESEREFYFDRNPALFP 72

Human    80 YVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQEST 144
            ||||||:||:||||.|||:||||||:|||||:..|:|:|||.:||.|::||.    .|:|:|.||
Zfish    73 YVLHFYNTGRLHVMDELCIFSFSQEMEYWGIDALFLDACCSAAYHCRRMEPA----GERSEQHST 133

Human   145 TSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVVMGSIITMCLNSL 209
            .||.:::|..|:.|.:|:.||||..||::||.||:|.||..||:.|.||:||::.||..|||||:
Zfish   134 ASSVEQMLELYSAAGRFETQPLGRLRRRVWLTLDHPAYSACSRLLSALSVLVLLASIACMCLNSM 198

Human   210 PDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYIT 274
            .:|.:.|:.|...||||||.||..||.|||.||:||.|.|||..:.....|.||||:|::|||:.
Zfish   199 SEFALRDAAGRLHEDPRFETVERLGIGWFTLELLARLAAAPDLRRCLLQPLTLIDLLSVLPFYLA 263

Human   275 LVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVG 339
            |::.| .||.| |.||||.||||||||:.|:|:|.|||||||||||||.:|.:|||||||||:||
Zfish   264 LLLQL-AESCP-LLNLGRAAQVLRLMRVLRVLQLVRHSTGLRSLGATLAHSLQEVGLLLLYLAVG 326

Human   340 ISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVL 404
            :..|||:|||:|:|.:|||.::||.||||||||||||||||||.:..|||||:||||||||:|||
Zfish   327 VCFFSVMAYTVEQEGSEGLGSVPASWWWATVSMTTVGYGDVVPASALGKLTAAACILAGILMVVL 391

Human   405 PITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSE 469
            ||||||||||.||:||::||..:|.|....|:|..|::.|.|||.||:|||||||||||||..|:
Zfish   392 PITLIFNKFSLFYKRQQRLELLVRRCPLDAGLKVAPALRLTDYYTHKMKSLMASLTNMSRSEHSD 456

Human   470 LSLNDSL 476
            .||..:|
Zfish   457 HSLELTL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	77/105 (73%)
		Ion_trans	186..421	CDD:459842	153/234 (65%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
kcns2	XP_073781759.1	None