Protein Alignment KCNS2 and kcns2

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_004915190.2
• Gene: kcns2 / 101732753
• XenbaseID: XB-GENE-29077351
• Length: 477
• Species: Xenopus tropicalis
• Alignment Length: 477
• Identity: 396/477 - (83%)
• Similarity: 439/477 - (92%)
• Gaps: 0/477 - (0%)

Human     1 MTGQSLWDVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDV 65
            |||:.|..:.:...||.||.|||||:|:|||..||.|||||||.:||.|.|:|:||||||||||.
 Frog     1 MTGEILMGLPDTGFEDTEISINVGGYKKRLRYDTLRRFPETRLCKLLACRSKESILELCDDYDDT 65

Human    66 QREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEP 130
            :.||||||||||||||||||:|||||||.|||||||.||||||||||||||||||||||||||||
 Frog    66 KNEFYFDRNPELFPYVLHFYNTGKLHVMGELCVFSFCQEIEYWGINEFFIDSCCSYSYHGRKVEP 130

Human   131 EQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSIL 195
            ||::|:|.|::||||||||||||||:||:|||.|||||.||:|||||||||||:|||:|||||||
 Frog   131 EQDQWEENSERESTTSSFDEILAFYHDAAKFDRQPLGNIRRRLWLALDNPGYSILSRIFSILSIL 195

Human   196 VVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNAL 260
            ||:|||:||||||||:||:.::.|:..|||||||||||||||||.|||.||:|:||...|||:.|
 Frog   196 VVLGSIVTMCLNSLPEFQVVNANGSVEEDPRFEIVEHFGIAWFTLELVVRFSVSPDLSLFFKHPL 260

Human   261 NLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYS 325
            |:||.:||.||||||:|||||||:|||.|||||||||||||||||||||||||||||||||||||
 Frog   261 NIIDFISIAPFYITLIVNLVVESSPTLVNLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYS 325

Human   326 YKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLT 390
            |:||||||||||||||||||||||||||||:||||||||||||||||||||||||||||.|||||
 Frog   326 YREVGLLLLYLSVGISIFSVVAYTIEKEENDGLATIPACWWWATVSMTTVGYGDVVPGTIAGKLT 390

Human   391 ASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSL 455
            ||||||||||||||||||||||||||||||||||:||||||||||:|:|||||||||||||||:|
 Frog   391 ASACILAGILVVVLPITLIFNKFSHFYRRQKQLENAMRSCDFGDGVKDVPSVNLRDYYAHKVKTL 455

Human   456 MASLTNMSRSSPSELSLNDSLR 477
            ||||||||:|||||.||.||::
 Frog   456 MASLTNMSKSSPSEQSLTDSIQ 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	87/105 (83%)
		Ion_trans	186..421	CDD:459842	203/234 (87%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
kcns2	XP_004915190.2	BTB_POZ_KCNS2	18..124	CDD:349734	87/105 (83%)
		Ion_trans	186..421	CDD:459842	203/234 (87%)