Protein Alignment KCNS2 and kcnf1b

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_005157014.1
• Gene: kcnf1b / 100334378
• ZFINID: ZDB-GENE-090312-39
• Length: 484
• Species: Danio rerio
• Alignment Length: 428
• Identity: 160/428 - (37%)
• Similarity: 257/428 - (60%)
• Gaps: 28/428 - (6%)

Human    10 SEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSR--EAILELCDDYDDVQREFYFD 72
            |.::.::.||.:|:||.:..|....|.|:|::||..|:.|.:|  :.|..||||||..:||||||
Zfish    14 SSSSSDEKEIAVNIGGVRLVLCGDILNRYPDSRLAELVNCPTRSFDVISSLCDDYDPGKREFYFD 78

Human    73 RNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDE 137
            |:|:.|..::..|:.|::|:...:|...|.:|:|:|.|:..::|.||              |.:.
Zfish    79 RDPDSFKCIVEVYYFGEVHMKRGICPICFIKEMEFWKIDLSYLDECC--------------KSNL 129

Human   138 QSDQESTTSSFDEILAFYND------ASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILV 196
            ...:|......|::....:|      .|:.:     .:::.:|..::.|..|:.:||.:::|.|.
Zfish   130 TEKEEELAEIADKVKLILDDLECDPAVSRTE-----RWQKFVWKLMEKPESSLPARVIAVVSFLF 189

Human   197 VMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALN 261
            ::.|.:.|||.:|||.|:.||:||..|.|..:.:|...|.|||.|.|.|.|.:|:.|:|..:.:|
Zfish   190 ILISSVVMCLGTLPDLQVEDSEGNRVEHPSLDAIETACIGWFTVEYVLRLASSPNKLRFALSFMN 254

Human   262 LIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSY 326
            :||.::::|||:.||:..:..:...|.|:.:..|.||:|||.||.||||||:||::|...||.|:
Zfish   255 MIDFLAVLPFYVVLVLTCLGTAMMELVNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSF 319

Human   327 KEVGLLLLYLSVGISIFSVVAYTIEKEENEGL-ATIPACWWWATVSMTTVGYGDVVPGTTAGKLT 390
            ||:||||:|:.|||.:||.:.||:|:...|.| .:||..:|||.::||||||||:.|.||.|:..
Zfish   320 KELGLLLMYMGVGIFVFSALGYTMEQSHPETLFRSIPQSFWWAIITMTTVGYGDIYPKTTLGRCN 384

Human   391 ASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMR 428
            |:...|.|::.:.|||..|.|.|..:|.:||.||:|.:
Zfish   385 AAISFLCGVIAIALPIHPIINNFVIYYNKQKVLETAAK 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	42/107 (39%)
		Ion_trans	186..421	CDD:459842	104/235 (44%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
kcnf1b	XP_005157014.1	BTB_POZ_Kv5_KCNF1	22..136	CDD:349690	44/127 (35%)
		Ion_trans	179..415	CDD:459842	104/235 (44%)