Protein Alignment KCNS2 and si:dkey-43k4.5

DIOPT Version :10

• Sequence 1: NP_065748.1
• Gene: KCNS2 / 3788
• HGNCID: 6301
• Length: 477
• Species: Homo sapiens
• Sequence 2: XP_021332757.1
• Gene: si:dkey-43k4.5 / 100148290
• ZFINID: ZDB-GENE-120215-82
• Length: 487
• Species: Danio rerio
• Alignment Length: 427
• Identity: 260/427 - (60%)
• Similarity: 324/427 - (75%)
• Gaps: 6/427 - (1%)

Human     9 VSEANV------EDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQR 67
            |.|.|.      :|..:.|||||.:..|.|..|.:||:||||:||.|.|.:.||:||||:|..::
Zfish     2 VKEKNAWWILDPKDHLLHINVGGLRNTLCSSILKKFPDTRLGQLLSCDSEDDILQLCDDFDVQRK 66

Human    68 EFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQ 132
            ||||||||.|||||||||.|||||:|.|||:||||||||||||::||:||||||.|..||:|...
Zfish    67 EFYFDRNPGLFPYVLHFYQTGKLHIMEELCIFSFSQEIEYWGISDFFLDSCCSYRYLDRKLERHH 131

Human   133 EKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSILSILVV 197
            :.|||:||..|..:|.|||.....|...|.....||.|:.|||.|:|||||:.|::||:|||.||
Zfish   132 KSWDEESDVSSVDTSVDEISDLNKDIEHFHEMRFGNIRKCLWLTLENPGYSIPSKLFSLLSICVV 196

Human   198 MGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNL 262
            :.||.|||:||:|::|..|..||..|||...::|.|.|.|||||:|.|..:||:..|||...||:
Zfish   197 LISIATMCINSIPEYQKFDENGNLIEDPTMHVLEVFCICWFTFEVVTRMLLAPNHRKFFLLPLNV 261

Human   263 IDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYK 327
            ||::|::|.|||:..::::.|...|.|||::.||||||||||:|||||||||||||||||::||:
Zfish   262 IDIISVMPIYITIFFDMLIGSESELGNLGKLVQVLRLMRIFRVLKLARHSTGLRSLGATLRHSYR 326

Human   328 EVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTAS 392
            |||:|||||:||:|:||.:|||.|.||:.||.||||||||.||||||||||||||.|.||||.||
Zfish   327 EVGILLLYLAVGVSVFSGMAYTAENEEDVGLDTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAAS 391

Human   393 ACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRS 429
            .|||.|.|||.||||:||||||||||:||.||:::|:
Zfish   392 GCILGGTLVVALPITIIFNKFSHFYRKQKALEASVRN 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNS2	NP_065748.1	BTB_POZ_KCNS2	18..124	CDD:349734	71/105 (68%)
		Ion_trans	186..421	CDD:459842	152/234 (65%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
si:dkey-43k4.5	XP_021332757.1	BTB_POZ	18..122	CDD:453885	71/103 (69%)
		Ion_trans	185..420	CDD:459842	152/234 (65%)