DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Hecw1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_006516872.1	Gene:	Hecw1 / 94253	MGIID:	2444115	Length:	1605	Species:	Mus musculus

Alignment Length:	1003	Identity:	227/1003 - (22%)
Similarity:	388/1003 - (38%)	Gaps:	246/1003 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 PPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYF 277
            |.||.|:.:...|..:.|             |:.||..:.         :.:.|.:|...|....
Mouse   754 PELDPESTNGAGPWQDEL-------------AAPGGNAAR---------STEGLESPMAGPSNRR 796

  Fly   278 VLPCFALNVDFPFDLLMRSL------YDALESAGPAESDSTSSRRSFLFYGVETGHKTTRM---- 332
            ...|..|:...|...| .||      |..::...|...::.......:|| |:..::||..
Mouse   797 EGECPILHNSQPISQL-PSLRPEHHHYPTIDEPLPPNWEARIDSHGRVFY-VDHINRTTTWQRPS 859

  Fly   333 -----DSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHR 392
                 |.:..|..::.:..|:||     :|:                 :|...:|.|...::
Mouse   860 MAPTPDGMIRSGSVHQMEQLNRR-----YQN-----------------IQRTMATERAEEDS--- 899

  Fly   393 HRDGDDDSEESED--------EDEELPAAR-TLDYDMEQTCRTSGELSVKERECLLESIAILNET 448
               |:.:||:..|        .|.|..::: :||      .|..|.||....    :.:.:|.::
Mouse   900 ---GNQNSEQIPDGGGGGGGGSDSEAESSQSSLD------LRREGSLSPVNS----QKVTLLLQS 951

  Fly   449 ERVDFIVQQLDPHIENT-HLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIR------AVW 506
            ..|.||.   :|..... |..|:.      ..::......::.:|........|.|      .|.
Mouse   952 PAVKFIT---NPEFFTVLHANYSA------YRVFTSSTCLKHMILKVRRDARNFERYQHNRDLVN 1007

  Fly   507 FKLAAESTQLGFSAPLTLISKG--VVPKHQG----VDRTIPLLATFCMLFGRLLPTLHD---VEF 562
            |......|:|.       :.:|  :...|||    ||                    |:   ..|
Mouse  1008 FINMFADTRLE-------LPRGWEIKTDHQGKSFFVD--------------------HNSRATTF 1045

  Fly   563 VENKLLLQVHSTINHV-------RLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKV 620
            ::.::.||.....||:       ||..:|..|..::|:     :.|...||.|
Mouse  1046 IDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSR-----NRGASLLARP------------ 1093

  Fly   621 LGHTEADDKKLRHQKQIWANLLN--VVVFV---------------LNQIHTRDLRLGFCPEDHWT 668
             ||:.....:.:||.:......|  :|.|:               |.:.||...::      |:.
Mouse  1094 -GHSLIAAIRSQHQHESLPLAYNDKIVAFLRQPNIFEMLQERQPSLARNHTLREKI------HYI 1151

  Fly   669 VTRLDLPLDR---PTDLPLTHSSRLRGIRPFQPIRDFTREDFENGP-------PMSTKQIRSITI 723
            .|..:..||:   ..||.:..|.....|..:.|::......:...|       |.::..::..:.
Mouse  1152 RTEGNHGLDKLSCDADLVILLSLFEEEIMSYVPLQSAFHPGYSFSPRCSPCSSPQNSPGLQRASA 1216

  Fly   724 LREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGP-SVLITVRRSHLYEDAYDKLRPDNEP 787
            ....|:...|..::....     .|:..:|    |.||| .:.:.:||.||.|..::::...:..
Mouse  1217 RAPSPYRRDFEAKLRNFY-----RKLEAKG----FGQGPGKIKLIIRRDHLLEGTFNQVMAYSRK 1272

  Fly   788 DL-RFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDN----KLYPNPNV 847
            :| |.|..|.||.     |.|:|..|..|||...|.:..|:|..|.|..:.::    ::.|   :
Mouse  1273 ELQRNKLYITFVG-----EEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISP---M 1329

  Fly   848 ADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFF-------LTKLAGKYSDVDIHQLASLDPE 905
            :...|:|.:.:.|.|||||.::....|::    .||       |.||     ..|:..|..||.|
Mouse  1330 SAFVENYLEWFRFSGRILGLALIHQYLLD----AFFTRPFYKGLLKL-----PCDLSDLEYLDEE 1385

  Fly   906 LYRNLLYLKDYSGDVSE-LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLN 969
            .:::|.::||  .:::: |:|.|||.....||....|||..|.:..||..|:.||::.:..:::.
Mouse  1386 FHQSLQWMKD--NNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVE 1448

  Fly   970 VQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISG-AEIPIDLEDLKKHCEYGGEFSPEHPSI 1033
            ..:.:...|..:|...|:....:.:|..:||:::|:| ||  |||.|.:.:.||.|.:...|..|
Mouse  1449 RGVVQQTEALLRGFYEVVDSRLVSVFDARELELVIAGTAE--IDLNDWRNNTEYRGGYHDGHLVI 1511

  Fly  1034 VTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPP-----FFIQNTGDMERLPTASTCTNL 1093
            ..||..:|.|::.||.:||:|||..|..|..||..|...     |.|:..|.:..||.|.||.|.
Mouse  1512 RWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGKITSLPRAHTCFNR 1576

  Fly  1094 LKLPPFKTVEQMREKLLYAIQSGAGFEL 1121
            |.|||:.:...:.||||.|::..:.|.|
Mouse  1577 LDLPPYPSYSMLYEKLLTAVEETSTFGL 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	115/372 (31%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	110/349 (32%)
Hecw1	XP_006516872.1	HECW_N	66..185	CDD:374632
		C2_NEDL1-like	206..342	CDD:176073
		Neuromodulin	378..500	CDD:369001
		WW	829..858	CDD:366073	6/29 (21%)
		HECW1_helix	947..1013	CDD:375862	12/74 (16%)
		WW	1019..1050	CDD:197736	8/50 (16%)
		HECTc	1249..1603	CDD:238033	115/374 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810