DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and TRIP12

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_024308991.1	Gene:	TRIP12 / 9320	HGNCID:	12306	Length:	2092	Species:	Homo sapiens

Alignment Length:	1438	Identity:	299/1438 - (20%)
Similarity:	486/1438 - (33%)	Gaps:	481/1438 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRRKRAEREVFDIYLMGHKDGIVEDE-S 89
            ||:::|..         .|..:||:......|...|..  .|.:..:.::  ..|:.|  ||| |
Human   795 DTMLKKGN---------AQNTDGAIWQWRDDRGLWHPY--NRIDSRIIEV--AAHQVG--EDEIS 844

  Fly    90 LTFLLR----RLNFFYSIREAKDSERLIEVCQQILRQP--------------------ARLLQHS 130
            |:.|.|    ..|....|.|...:.|.|:      |:|                    |:|::.
Human   845 LSTLGRVYTIDFNSMQQINEDTGTARAIQ------RKPNPLANSNTSGYSESKKDDARAQLMKE- 902

  Fly   131 SPDSLWLLRLCKLLDTCLLQLSLSHTAQAIPLRMLET------FTTVSSVQQYMKDEAV------ 183
              |........|.|...|.::..|....|:..:.|..      |.....::..:|:.||
Human   903 --DPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNHAVSSHIAS 965

  Fly   184 --LFQYMERVFGFLIARNYFVRLRRLLDDKCPPL-------DGETLHAPSPLAEALLQLLLRPLE 239
              ..|.::.|.|.|       ::..:|..|.|.:       :| .:|....|||:...|...|..
Human   966 MLSSQDLKIVVGAL-------QMAEILMQKLPDIFSVYFRREG-VMHQVKHLAESESLLTSPPKA 1022

  Fly   240 VAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLMRS-LYDALES 303
            ....:.:.|..:|:|...         ||..|........|....:.|...||..:. |.|.|:.
Human  1023 CTNGSGSMGSTTSVSSGT---------ATAATHAAADLGSPSLQHSRDDSLDLSPQGRLSDVLKR 1078

  Fly   304 -------------AGPAESDSTSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATL 355
                         :.|.:.|...::          ....|...|..|||            ||:|
Human  1079 KRLPKRGPRRPKYSPPRDDDKVDNQ----------AKSPTTTQSPKSSF------------LASL 1121

  Fly   356 HQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDDDSEE------------------ 402
            :..    .:.||..:...|.:: |..|..|...|....:|...::.|
Human  1122 NPK----TWGRLSTQSNSNNIE-PARTAGGSGLARAASKDTISNNREKIKGWIKEQAHKFVERYF 1181

  Fly   403 -SEDEDEELPAARTLDYDMEQTCRTSGELSVK---ERECLLESIAILNETERVDFIVQQLDPHIE 463
             ||:.|...||...|    ::.|..:.:|:::   ..|||:|..:|::|::...|.:|
Human  1182 SSENMDGSNPALNVL----QRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQ------- 1235

  Fly   464 NTHLIYALCEICHNLMIYNKHAVF-EYKLLYTLAFTPK--FIRAVWFKLAAESTQLGFSAPLTLI 525
                                |:.| :..|||..:.:.|  ..|.:..|   ....:.||:||
Human  1236 --------------------HSGFVKQLLLYLTSKSEKDAVSREIRLK---RFLHVFFSSPL--- 1274

  Fly   526 SKGVVPKHQGVDR-----TIPLLATF-----CMLFGRLLPT-LHD--------------VEFVEN 565
                 |..:.:.|     ..||||..     |:......|. :||              ::|...
Human  1275 -----PGEEPIGRVEPVGNAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGTGGRGSQALKFFNT 1334

  Fly   566 ---KLLLQVHSTINH--------VRLMPFSIAEIIQMSKTLK-------------------DISM 600
               |..||.|....:        |::.|.::.:.|:....::                   :|..
Human  1335 HQLKCQLQRHPDCANVKQWKGGPVKIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEEIDE 1399

  Fly   601 GLVELAFPETRSNLANYRKVLG---------HTEA----DDKKLRHQKQ--IWANLL--NVVVF- 647
            .||....| |..|:  ..||.|         ..:|    :...:||:.|  |..:||  |:.|:
Human  1400 SLVRYYIP-TMYNV--LYKVQGLWLKWLLLCFIQAAQFLNSGNVRHRLQFYIGEHLLPYNMTVYQ 1461

  Fly   648 VLNQ--IHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENG 710
            .:.|  |...|.|.....|.:        ||.|......||:..      ::|:    |||.|:.
Human  1462 AVRQFSIQAEDERESTDDESN--------PLGRAGIWTKTHTIW------YKPV----REDEESN 1508

  Fly   711 ------------------PPMSTKQIRSI-------------------TILREIPFVVPFNKRVS 738
                              .|.:.|:...:                   |....|.|..|....:.
Human  1509 KDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVSNPLEVYLIPTPPENITFEDPSLDVIL 1573

  Fly   739 ILQSLVAA------------------------SKMRVQGNMQAFLQGPSVLIT------------ 767
            :|:.|.|.                        ||:..:.|.|  ||.|.|::|
Human  1574 LLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQ--LQDPLVIMTGNIPTWLTELGK 1636

  Fly   768 ---------VRRSHLYEDAYDKLRP-----DNEPDL---------------RFKFRIQFVSSLGL 803
                     .|:...|..|:|:.|.     |..|::               |.|..:.....|..
Human  1637 TCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQ 1701

  Fly   804 DEAGIDGGGVFREFL----SELIKTAFDPNRGFFMVTT-------------DNKLYPNP------ 845
            .|:.:...|..|..|    ...:.|...|...|:.:.:             :.....||
Human  1702 AESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFYALVSQELQRADLGLWRGEEVTLSNPKGSQEG 1766

  Fly   846 -----NVADLF-------------EDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYS 892
                 |:..||             ...:..:.|:|:::.|:|.:..||:|||...|...:..:.:
Human  1767 TKYIQNLQGLFALPFGRTAKPAHIAKVKMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQET 1831

  Fly   893 DVDIHQLASLDPELYRNLLYLKD---------------------------YSG-DVSELNLDFTV 929
            .:..|.|..:||.:.|::.:|:|                           .:| .|.:|.||||
Human  1832 SLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFT- 1895

  Fly   930 ASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYM 994
                |.....:|||..|:.||||..|..|||:|:..:.||..:.|..::||.|..:|.|:..|..
Human  1896 ----LPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVSRQFDSFRDGFESVFPLSHLQY 1956

  Fly   995 FSNKELQILISGAEIPI-DLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSC 1058
            |..:||..|:.|::... |.:.|.:.|.....::.:..::...:|:|..||:.|:|..|:|||..
Human  1957 FYPEELDQLLCGSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGS 2021

  Fly  1059 SRPPLLGFKDLDPPFFI--------QNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
            .|.|:.||:.|:||..|        :|..|.  ||:..||.|.||||.:.::|.||||||.|.:.
Human  2022 PRLPVGGFRSLNPPLTIVRKTFESTENPDDF--LPSVMTCVNYLKLPDYSSIEIMREKLLIAARE 2084

  Fly  1116 G-AGFELS 1122
            | ..|.||
Human  2085 GQQSFHLS 2092

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	116/473 (25%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	108/424 (25%)
TRIP12	XP_024308991.1	SR-25	99..>233	CDD:313680
		Arm_3	489..>714	CDD:330530
		WWE	808..874	CDD:308464	19/77 (25%)
		HECTc	1690..2090	CDD:238033	107/406 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810