Protein Alignment CG3356 and UBE3B

DIOPT Version :9

• Sequence 1: NP_611896.1
• Gene: CG3356 / 37876
• FlyBaseID: FBgn0034989
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_569733.2
• Gene: UBE3B / 89910
• HGNCID: 13478
• Length: 1068
• Species: Homo sapiens
• Alignment Length: 1226
• Identity: 359/1226 - (29%)
• Similarity: 534/1226 - (43%)
• Gaps: 302/1226 - (24%)

  Fly    29 IRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRRKR-AEREVFDIYLMGHKDGIVEDESLTF 92
            |.:|...|::|...:::|..|||:|::.|||:.|.|.:| ..||:.|.:.....:.........|
Human    13 IDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIF 77

  Fly    93 -LLRRLNFFYSIREAKDSERLIEVCQQILRQPARLLQHSSPDS-------------------LWL 137
             :.|:|.|.:.|:|  |:||..::|:.||         ||.|:                   ||:
Human    78 KIARKLLFLFRIKE--DNERFEKLCRSIL---------SSMDAENEPKVWYVSLACSKDLTLLWI 131

  Fly   138 LRLCKLLDTC----------LLQLSLSHTAQAIPLRMLETFTTVSSVQQYM-KDEAV---LFQYM 188
            .::..:|..|          :||.|...|   :.|.||.|||..|:.:... |.|::   :....
Human   132 QQIKNILWYCCDFLKQLKPEILQDSRLIT---LYLTMLVTFTDTSTWKILRGKGESLRPAMNHIC 193

  Fly   189 ERVFGFLIARNYF----VRLRRLLDDKCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQ 249
            ..:.|.|....::    :.|.|.|....|.|...||.|...||       |||:..|:
Human   194 ANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLA-------LRPVIAAQ------- 244

  Fly   250 MSSMSMAVCRNFTRDILATP----HT--------------DPLRYFVLPCFALNVDFPFDL---- 292
               .|..:.|.|...|::.|    |.              |.||.|::  |..:.|...|:
Human   245 ---FSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFII--FLRDQDRCRDVCESL 304

  Fly   293 -------LMRSLYDALESAGP----AESDS---------------TSSRRSFLFYGVETGHKTTR 331
                   ||.:|.. |.|..|    .|:|.               .|.::|.|.:    .|....
Human   305 EGCHTLCLMGNLLH-LGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTH----WHPVLG 364

  Fly   332 MDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDG 396
            ..|....:.||..|.|..:||..|...||:.|:...|         |.|..|
Human   365 WFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDI---------LSKKLL------------- 407

  Fly   397 DDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKE--RECLLESIAILNETERVDFIVQQLD 459
                 ||::.....||:            ....|.||.  :....:|.::.|       |::.:.
Human   408 -----ESQEPAHAQPAS------------PQNVLPVKSLLKRAFQKSASVRN-------ILRPVG 448

  Fly   460 PHIENTHLIYALCEICHNLMIYNKHAV----FEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSA 520
            ....::..:..:|.||   ::|.....    ...::|..|.:....:..:|    |...:||...
Human   449 GKRVDSAEVQKVCNIC---VLYQTSLTTLTQIRLQILTGLTYLDDLLPKLW----AFICELGPHG 506

  Fly   521 PLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSI 585
            .|.|..:.:....:...:.:.:|..||.....|:..|.|:|..|.::              .|.:
Human   507 GLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQI--------------SFKL 557

  Fly   586 AEIIQMSKTL-----KDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVV 645
            .|::.:|..|     |.|..|:||.|..||   |..::.|.|               |
Human   558 EELVTISSFLNSFVFKMIWDGIVENAKGET---LELFQSVHG---------------W------- 597

  Fly   646 VFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPI-RDFTREDFEN 709
               |..::.||.|..|.|||||  .|.||   :|:.|             ||.: ||
Human   598 ---LMVLYERDCRRRFTPEDHW--LRKDL---KPSVL-------------FQELDRD-------- 633

  Fly   710 GPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVL-ITVRRSHL 773
                   :.|:..||:.||.|:|...||.:.:::|...|.:: |.::.....|.|. ||:|||.:
Human   634 -------RKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKL-GLVETSSASPHVTHITIRRSRM 690

  Fly   774 YEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTT- 837
            .||.|::||..::..::...|::||:.||:||||||..|||:|||.|:||..|||....|..|:
Human   691 LEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSG 755

  Fly   838 DNKLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGK-----YSDVDIH 897
            |.:|||:| .:.:.|:|.:.:.|:|::|||::||.::|::|.|.|||::|.|.     ||.||
Human   756 DERLYPSP-TSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVD-- 817

  Fly   898 QLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQL 962
            :|.|||.|.|:||..:|.|.||:::|.|..:.....:||....||.|.|::|||||.|:|.|:.|
Human   818 ELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHL 882

  Fly   963 IADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFS 1027
            :|.::::.||:....|...|..:::..||:.|||..|||.||||....|||||||||..|.|.|.
Human   883 MAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFH 947

  Fly  1028 PEHPSIVTFWEVL-EGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFI--------QNTGDM-- 1081
            ..|..|:..|::| ..|...:|...|||||||||||||||..|.|||.|        |:|||.
Human   948 GSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLG 1012

  Fly  1082 ---------------ERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
                           .||||:|||.||||||.:.....:||||.|||....|||||
Human  1013 SVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	170/385 (44%)
		HECTc	788..1119	CDD:214523	159/362 (44%)
UBE3B	NP_569733.2	HECTc	682..1066	CDD:238033	170/386 (44%)
		HECTc	707..1065	CDD:214523	159/360 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750