DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and HERC3

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_055421.1	Gene:	HERC3 / 8916	HGNCID:	4876	Length:	1050	Species:	Homo sapiens

Alignment Length:	786	Identity:	186/786 - (23%)
Similarity:	309/786 - (39%)	Gaps:	174/786 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 SGELSVKERECLLESIAILNETERVDF-IVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFE-- 488
            ||:||.:              .:|..: ||:|:....:.|   :.||....|   |:....|.
Human   349 SGQLSAR--------------ADRFKYHIVKQIFSGGDQT---FVLCSKYEN---YSPAVDFRTM 393

  Fly   489 YKLLYTLAFTPKFIRAVW-FKLAAESTQLGFSAPLTLISKGVV-----------------PKHQG 535
            .:..||.....:.| ||| .||:..:.....:..:.::|....                 ||..|
Human   394 NQAHYTSLINDETI-AVWRQKLSEHNNANTINGVVQILSSAACWNGSFLEKKIDEHFKTSPKIPG 457

  Fly   536 VDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISM 600
            :|                   |:....:..||:...||.|....|..|....|.|:|.:..|:..
Human   458 ID-------------------LNSTRVLFEKLMNSQHSMILEQILNSFESCLIPQLSSSPPDVEA 503

  Fly   601 GLVELAFPE---------------------TRSNLANYRKVLGH--TEADDK------------- 629
            ..:.|..||                     .|.: .|..|||.:  ::...|
Human   504 MRIYLILPEFPLLQDSKYYITLTIPLAMAILRLD-TNPSKVLDNWWSQVCPKYFMKLVNLYKGAV 567

  Fly   630 --KLRHQKQ-----IWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTD--LPLT 685
              .||.:|.     ::.|.:...:.:|.:::..:|::.....|.:.:..:...:|...|  :...
Human   568 LYLLRGRKTFLIPVLFNNYITAALKLLEKLYKVNLKVKHVEYDTFYIPEISNLVDIQEDYLMWFL 632

  Fly   686 HSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKMR 750
            |.:.::. ||                    ..|:....|...||:.....:..:||: .|..:|:
Human   633 HQAGMKA-RP--------------------SIIQDTVTLCSYPFIFDAQAKTKMLQT-DAELQMQ 675

  Fly   751 VQ---GNMQ-AFL---------QGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLG 802
            |.   .|:| .|:         :.|.:::.|||::|..||..:|...::.||:...::.|..
Human   676 VAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNNLVGDALRELSIHSDIDLKKPLKVIFDG--- 737

  Fly   803 LDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED--YEKHYYF--IGR 863
              |..:|.|||.:||...|:|...:|..|.|....|:.|.       .|.|  :.:|.:|  ||.
Human   738 --EEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLL-------WFSDTCFVEHNWFHLIGI 793

  Fly   864 ILGKSIYENLLVEL--PLAEFFLTKLAGKYSDV--DIHQLASLDPELYRNLLYLKDYSG-DVSE- 922
            ..|.:||.:.:|:|  |||      |..|..:|  .:..|..|.|...|:|..|.||.| ||.|
Human   794 TCGLAIYNSTVVDLHFPLA------LYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEET 852

  Fly   923 LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVL 987
            ..|:||:...|.|..:..:|.|.|.::.|...||.|::....:|...:.:.....||..|...|.
Human   853 FCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQISVHEWYTAFSSGFLKVC 917

  Fly   988 PIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLL 1052
            ..:.|.:|...||:.::.| ....:.|:|::...|.|::|..||::..|||....|...::::.|
Human   918 GGKVLELFQPSELRAMMVG-NSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFL 981

  Fly  1053 KFVTSCSRPPLLGFKDLDPPFFIQNTGDMER-LPTASTCTNLLKLPPFKTVEQMREKLLYAIQSG 1116
            .|:|...|.|:.|...|.  ..||:|...|. ||.|.||.|||.||.:.:.|.:..:|..|:.:.
Human   982 LFLTGSDRIPIYGMASLQ--IVIQSTASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNY 1044

  Fly  1117 AGFELS 1122
            .||.|:
Human  1045 EGFSLA 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	111/364 (30%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	103/341 (30%)
HERC3	NP_055421.1	RCC1 1	1..51
		ATS1	2..331	CDD:227511
		RCC1 2	52..101
		RCC1 3	102..154
		RCC1 4	156..207
		RCC1 5	208..259
		RCC1 6	261..311
		RCC1	313..377	CDD:366085	9/44 (20%)
		RCC1 7	313..366		7/30 (23%)
		HECTc	702..1048	CDD:238033	111/366 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810