DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and WWC2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_011530571.1	Gene:	WWC2 / 80014	HGNCID:	24148	Length:	1216	Species:	Homo sapiens

Alignment Length:	1042	Identity:	194/1042 - (18%)
Similarity:	335/1042 - (32%)	Gaps:	351/1042 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LERQKRNELRQKENGAVVLQSYARSFIHRQRRKRAEREVFDIYLMGHKDGIVEDESLTF------ 92
            :|::|...:.:||.....||     |:..|:|.:.|.|..:.     :...:|:|.|:.
Human   340 IEKEKLMLINEKEELLKELQ-----FVTPQKRTQDELERLEA-----ERQRLEEELLSVRGTPSR 394

  Fly    93 -LLRRLNFFYSIREAKDSERLIEVCQQILRQPARLLQHSSPDSLWLLRLCKLLDTCLLQL----- 151
             |..||             ||.|..:::|::    |:.::..:.:|....|.|....|.:
Human   395 ALAERL-------------RLEERRKELLQK----LEETTKLTTYLHSQLKSLSASTLSMSSGSS 442

  Fly   152 --SLSHTAQAIPLRMLETFTTVSSVQQYMKDEA----VLFQYMERVFGFLIARNYFVRLRRLLDD 210
              ||:.:..::......:..::||.:.|...::    |.:||               :|..||.:
Human   443 LGSLASSRGSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQY---------------KLDFLLQE 492

  Fly   211 KCPPLDGETLHAPS-PLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPL 274
            |       :.:.|| |:.      .:...||.|..|..||.....:|..        ||.||.||
Human   493 K-------SGYIPSGPIT------TIHENEVVKSPSQPGQSGLCGVAAA--------ATGHTPPL 536

  Fly   275 RYFVLPCFALNVDFPFDLLMRSLYDALESAGPAES----DST---SSRRSFLFYGVETGHKTTRM 332
                       .:.|..:...|...:|.|..|..|    :.|   ||......:......:...:
Human   537 -----------AEAPKSVASLSSRSSLSSLSPPGSPLVLEGTFPMSSSHDASLHQFTADFEDCEL 590

  Fly   333 DSIFSSF-LLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDG 396
            .|.|:.. |:.:.::||                                |...|.:.:....:|.
Human   591 SSHFADISLIENQILLD--------------------------------SDSGGASQSLSEDKDL 623

  Fly   397 DDDSEE-----SEDEDEELPAARTLDYDMEQTCRTSGELS--------------VK---ERECLL 439
            ::.:.|     :.|.::.||..|.:....|:|...|..:|              ||   |.|.:.
Human   624 NECAREPLYEGTADVEKSLPKRRVIHLLGEKTTCVSAAVSDESVAGDSGVYEAFVKQPSEMEDVT 688

  Fly   440 ---ESIAILNETERVDF-------------IVQQLDPHIENTHLIYALCEICHNLMIYNKHAVF- 487
               |.:||: ||.:|..             |:.||    .|.|...    |.|...:|.:.||.
Human   689 YSEEDVAIV-ETAQVQIGLRYNAKSSSFMVIIAQL----RNLHAFL----IPHTSKVYFRVAVLP 744

  Fly   488 ---EYKLLYTLAFTPKFIRAVW---FKLAAESTQLGFSAPLTL-ISKGVVPKHQGVD-------- 537
               :...|:.....|.....::   |::|...|.|   ...|| :....|.||:..:
Human   745 SSTDVSCLFRTKVHPPTESILFNDVFRVAISQTAL---QQKTLRVDLCSVSKHRREECLAGTQIS 806

  Fly   538 -RTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAE-----IIQMSKTLK 596
             ..:|..:....|:..|||:                      :.||....|     :.|.::.|.
Human   807 LADLPFSSEVFTLWYNLLPS----------------------KQMPCKKNEENEDSVFQPNQPLV 849

  Fly   597 D-ISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLG 660
            | |.:..|......|.:.|....:.|...|.::.                    .|...|.
Human   850 DSIDLDAVSALLARTSAELLAVEQELAQEEEEES--------------------GQEEPRG---- 890

  Fly   661 FCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILR 725
              |:..|..|......:...|:                   |||        ::.|.:  :|:||
Human   891 --PDGDWLNTYFLCCWELKDDV-------------------FTR--------LTVKPL--LTMLR 924

  Fly   726 EIPFVVPFNKRVSI-----------LQSLVAASKMRVQGNMQAF-------LQGPSVLITV--RR 770
            |....:...|...:           |.|..:..:|...||.:..       .|.|:.:.|:  :.
Human   925 EASDEIVAEKEAEVKLPEDSSCTEDLSSCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTLVDKE 989

  Fly   771 SHLYEDAYDKL--RPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFF 833
            ::..|.|.|.:  ||.....|..: :..||.|..:..:.....|...:::..|.::..|.:
Human   990 TNTDEAANDNMAVRPKERSSLSSR-QHPFVRSSVIVRSQTFSPGERNQYICRLNRSDSDSS---- 1049

  Fly   834 MVTTDNKLYPNPNVADLF--EDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDI 896
              |...|        .||  ...|:....:.|.:.:|:......|.|:.    |.|     |:::
Human  1050 --TLAKK--------SLFVRNSTERRSLRVKRTVCQSVLRRTTQECPVR----TSL-----DLEL 1095

  Fly   897 HQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQS-IP--VTNSNRIE 958
            ...|||..:               |.|| |...|...|.| ::.|||.||:: :|  |....|.:
Human  1096 DLQASLTRQ---------------SRLN-DELQALRDLRQ-KLEELKAQGETDLPPGVLEDERFQ 1143

  Fly   959 YL 960
            .|
Human  1144 RL 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	44/204 (22%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	38/178 (21%)
WWC2	XP_011530571.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792	12/54 (22%)
		YlqD	351..>428	CDD:287979	21/103 (20%)
		C2_Kibra	700..823	CDD:176062	24/133 (18%)
		vWFA	<1058..>1153	CDD:294047	27/114 (24%)
		Phage_Nu1	<1117..1192	CDD:294991	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900