DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and ube3a

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001007319.1	Gene:	ube3a / 792398	ZFINID:	ZDB-GENE-041114-190	Length:	857	Species:	Danio rerio

Alignment Length:	834	Identity:	204/834 - (24%)
Similarity:	361/834 - (43%)	Gaps:	180/834 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   358 SPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQ 422
            |||    :|:|..:..:...|.:|..:...:.....:......|:.:::::|..:..:...::|.
Zfish   129 SPL----IRVIGRVFSSAESLVQSFRKAKQHTKEELKSLQAKDEDKDEDEKETASGSSTAMEVEP 189

  Fly   423 TCRTS-------GELSVKERECLLESIAI---------LNETERVD--FI--VQQLDPHIE---N 464
            ....|       ||.:|::...:..|:.|         |...|:::  |:  :..|.|::|   .
Zfish   190 EASASSGDGSSHGENNVQKLGPVEVSVDIDAVRRVYDRLLSNEKIEAAFLNALVYLSPNVECDLT 254

  Fly   465 THLIYALCEICHNLMIYNKHAVFEYKLLYTLAF----TPKFIRAVWFKLAAESTQLGFSAPLTLI 525
            .|.:||......|:.|    .|.|...|::..:    .|:|.:|: .||           ||..:
Zfish   255 YHNVYAADPNYLNVFI----IVMENSNLHSPEYLEIALPQFCKAM-SKL-----------PLPAL 303

  Fly   526 SK-GVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEII 589
            :| ..:....|||:...|:.||..|   :..|:...||..:.|:.:...              ::
Zfish   304 AKLARLWSQYGVDQIRRLVETFQQL---ITYTVISNEFSSDNLVNEDDG--------------VV 351

  Fly   590 QMSKTLKDISMGLVELAFPETRSNLANYRKVLG-------HTEADDKKLRHQKQIWANLLNVVVF 647
            ..:|.||                 :..|..|||       :.|.||:.:....::
Zfish   352 AATKCLK-----------------IVYYANVLGGDLDTDHNEEDDDEPIPESSEL---------- 389

  Fly   648 VLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPP 712
            .|.::...:.|....|       |:| ||:  |::.:..|...:.:.||        |:|.|.|.
Zfish   390 TLQELLGEERRNKKGP-------RVD-PLE--TEMGIRASDCRKPLIPF--------EEFINEPL 436

  Fly   713 MSTKQI-RSITILR----------EIPFVVP-----------------FNKRVSILQSLVAASKM 749
            ....:: :..|..:          ..||::.                 ..:|::.|.|||...::
Zfish   437 NEVLEMDKDYTFFKVETESKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITALYSLVQGQQL 501

  Fly   750 RVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLR---PDNEPDLRFKFRIQFVSSLGLDEAGIDGG 811
                       .|.:.:.|||.|:.:||..:|.   .:|..||:.:..::|..     |.|:|.|
Zfish   502 -----------NPYLRLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEG-----EQGVDEG 550

  Fly   812 GVFREFLSELIKTAFDPNRGFFMVTTDNKLY-PNPNVADLFEDYEKHYYFIGRILGKSIYENLLV 875
            ||.:||...:::..|:|:.|.|......||: .||:   .||: |..:..||.:||.:||.|.::
Zfish   551 GVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWFNPS---SFEN-EGQFTLIGIVLGLAIYNNCIL 611

  Fly   876 ELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE-LNLDFTVASSSL-GQTQ 938
            ::........||.||..  ....||...|.|:::|..|.:|.|:|.| :.:.|.::.:.| |...
Zfish   612 DVHFPMVIYRKLMGKKG--TFRDLADSHPVLFQSLKDLMEYEGNVEEDMMITFQISQTDLFGNPL 674

  Fly   939 IVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKG---LSNVLPIEWLYMFSNKEL 1000
            :.:||..|..|||||.||.:::.|.|:|.||..:.:...|||:|   ::|..|::  |:|..:|:
Zfish   675 MYDLKESGDKIPVTNENRKDFVALYAEYMLNKSVEKQFKAFRRGFHMVTNESPLK--YLFRPEEI 737

  Fly  1001 QILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLG 1065
            ::||.|:. .:|.:.|::..||.|.::.:...|..|||.:..|:..::|..|:|.|...|.|:.|
Zfish   738 ELLICGSR-NLDFQALEESTEYDGGYNKDSRIIRDFWETVHSFEQEKKRLFLQFTTGTDRAPVGG 801

  Fly  1066 FKDLDPPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            ...| .....:|..|.:||||:.||.|:|.||.:.|||:::|:||.||....||
Zfish   802 LGKL-KMIIAKNGPDSDRLPTSHTCFNVLLLPEYSTVEKLKERLLKAITYAKGF 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	121/363 (33%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	111/336 (33%)
ube3a	NP_001007319.1	AZUL	6..60	CDD:293166
		HECTc	505..855	CDD:238033	121/365 (33%)
		HECTc	532..854	CDD:214523	111/336 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810