DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and ube3c

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001072518.1	Gene:	ube3c / 779973	XenbaseID:	XB-GENE-1011935	Length:	1082	Species:	Xenopus tropicalis

Alignment Length:	1162	Identity:	451/1162 - (38%)
Similarity:	683/1162 - (58%)	Gaps:	120/1162 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGFDGEYRRRPVQSLGGASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRR 65
            ||.|:|:::.||..||.|||...|:.:::.:...||:||.|.|::...|:::||:.|.:..|:::
Frog     1 MFSFEGDFKTRPKVSLRGASKKEDKASLLHRTQEERRKREEERRRLKNAIIIQSFVRGYKDRKQQ 65

  Fly    66 KRAEREVFD--IYLMGHKDGIVEDESLTFLLRRLNFFYSIREAKDSERLIEVCQQILRQPARLL- 127
            ...:|..||  ........|.....:|..|:|:|.|||  |:.:||:|||.:||.:::|.::.:
Frog    66 YTIQRSEFDSCASSAAANGGATNGSNLVLLVRKLLFFY--RQNEDSKRLIWICQNLIKQNSQFVK 128

  Fly   128 QHSSPDSLWLL----RL----CKLLDTCL---LQLSLSHTAQAIPLRMLETFTTVSSVQQYMKDE 181
            |...||.|..|    ||    |:||..|.   |.:       |:|:||||.|::..:....::|.
Frog   129 QLMGPDRLTCLYQIKRLLGLCCRLLQQCQDDGLNV-------ALPMRMLEVFSSEVTYLAVLQDT 186

  Fly   182 AVLFQYMERVFGFLIARNYFVRLRRLLDDKCPP----LDGETLHAPSPLAEALLQLLLRPLEVAK 242
            ..:...:|::..::|.:.|:..|..|:::|.||    .|...:|    :|:.||:.:::||....
Frog   187 EYVASLVEQILHYMIQKGYYRSLYLLINNKLPPSIDYSDVSRVH----IAKVLLENVMKPLHFTY 247

  Fly   243 RASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFA-LNVDFPFDLLMRSLYDALESAGP 306
            .:...|....:..|    ||.:.||.|:||.:.:|::|..| |...||::..::    ||...|.
Frog   248 NSCPEGARQQVFTA----FTEEFLAAPYTDQIFHFIIPALADLQTAFPYETFLK----ALLKEGQ 304

  Fly   307 AESDSTSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEM 371
            ..| .||:...:|||.|.|..:|                     .|..|.:..:|. |:|::...
Frog   305 QHS-RTSNTAPWLFYFVLTVGET---------------------YLGNLSEEGMLK-YLRVLQIF 346

  Fly   372 MPNILQLPKSTLRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVK--E 434
            :.   |||.|:    :...|:..:.|     |||:|:::....|...|        |::||:  .
Frog   347 LS---QLPVSS----SGTNHQELNSD-----SEDDDDDITKMLTTAGD--------GKISVQYMT 391

  Fly   435 RECLLESIAILNETERVDFIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTP 499
            .|||.:    |:..::.:.::..:.....|..:...:..|||.||:.::..|.:.:|||:|||..
Frog   392 EECLKK----LDTKQQTNLLLNMVWRDSANEEVFTLMASICHTLMVQHRMMVPKVRLLYSLAFNA 452

  Fly   500 KFIRAVWFKLAAESTQL--GFSAP-LTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVE 561
            :|:|.:|:.:::.:|::  |...| |.:||:|.....:..:|.|||...|..||...|.::||.|
Frog   453 RFLRHLWYLISSMTTKMITGSRVPLLQVISRGSPMSLEDSNRIIPLFYLFSSLFSHSLISVHDNE 517

  Fly   562 FV--ENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSN-----LANYRK 619
            |.  ..::..|..|:     :|||::.::|.:|:.|:|..:|:::||:|||:..     :|.:|.
Frog   518 FFGDPREVAGQRQSS-----MMPFTLDQLIVLSRCLRDACLGIIKLAYPETKPEVREEYMAAFRS 577

  Fly   620 VLGHTEAD-DKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDL- 682
            :...|.|: .|:::.:::.|..|..|:..::..:.:||.|..|||.:||...:.::..|:.|.|
Frog   578 IGVTTNAEMQKQIQAEQKRWIQLFKVITNLVKMLKSRDARRNFCPFNHWLSEQENIKADKVTQLY 642

  Fly   683 --PLTHSSRLR---GIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQS 742
              ...|..|:|   .|.|.|...|...|.    .|:|..:.|.:.||.|:||||||.:||.|.|.
Frog   643 VPSARHVWRVRRMGRIGPLQSTLDVGLEP----APLSVSEERQLAILTELPFVVPFEERVKIFQR 703

  Fly   743 LVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAG 807
            |:.|.|..|||: ..|:.|  :.:|:||:::||||||||.|:|||||:.:.|:..:::.||||||
Frog   704 LIYADKQEVQGD-GPFIDG--INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNTHGLDEAG 765

  Fly   808 IDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED-YEKHYYFIGRILGKSIYE 871
            |||||:|||||:||:|:.|:||:|||..|.:..|||||....|..| :.:||||:||:|||::||
Frog   766 IDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYE 830

  Fly   872 NLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQ 936
            |:|||||.|.|||:||.|..:|||||.|||||||:|||||:||.|..||.||.|:|||.::.||:
Frog   831 NMLVELPFASFFLSKLLGTSADVDIHHLASLDPEMYRNLLFLKSYEDDVEELGLNFTVVNNDLGE 895

  Fly   937 TQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQ 1001
            .|:||||..|:.||||::|||.|:.|:|||:||.|||.||.|||:||:||:.:|||.||..:|||
Frog   896 AQVVELKAGGKDIPVTSANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVNLEWLRMFDQQELQ 960

  Fly  1002 ILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGF 1066
            :|||||::||.|:|||....|.|.:|.:|..|..||.|:|.|.|.::|:||||||||||||||||
Frog   961 VLISGAQVPICLDDLKSFTNYSGGYSADHAVIKIFWRVVENFTDEEKRKLLKFVTSCSRPPLLGF 1025

  Fly  1067 KDLDPPFFIQNTG-DMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
            |:|.|.|.|.|.| |:|||||||||.||||||.|.....|:.||||||:..||||||
Frog  1026 KELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEHLMKSKLLYAIECAAGFELS 1082

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	217/355 (61%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	201/332 (61%)
ube3c	NP_001072518.1	IQ	47..64	CDD:197470	5/16 (31%)
		HECTc	724..1080	CDD:238033	217/355 (61%)
		HECTc	746..1079	CDD:214523	201/332 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	378	1.000	Domainoid score	I847
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8783
Inparanoid	1	1.050	738	1.000	Inparanoid score	I597
OMA	1	1.010	-	-		QHG47393
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0005112
OrthoInspector	1	1.000	-	-		oto104697
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	1	1.000	-	-		X3631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110