DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Smurf1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_006504947.1	Gene:	Smurf1 / 75788	MGIID:	1923038	Length:	757	Species:	Mus musculus

Alignment Length:	462	Identity:	137/462 - (29%)
Similarity:	228/462 - (49%)	Gaps:	76/462 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   684 LTHSSRLRGIRPFQPIR---DFTREDFENGPPMSTKQ--IRSITILREIPFVVPFNKRVSILQSL 743
            :.|..:|:  .|.||::   :.:.|| |..|....::  ::.:.:||.         .:|:.|.
Mouse   343 MNHQCQLK--EPSQPLQLPSEGSVED-EELPAQRYERDLVQKLKVLRH---------ELSLQQP- 394

  Fly   744 VAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYD---KLRP-DNEPDLRFKFRIQFVSSLGLD 804
                            |.....|.|.|..::|::|.   |:|| |.:..|..|||         .
Mouse   395 ----------------QAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFR---------G 434

  Fly   805 EAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDN--KLYPNPNVADLFEDYEKHYYFIGRILGK 867
            |.|:|.|||.||:|..|.....:|..|.|..:|||  .|..||: :.:..|:..:::|:|||:|.
Mouse   435 EEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPD-SSINPDHLSYFHFVGRIMGL 498

  Fly   868 SIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE-LNLDFTVAS 931
            :::....:.......|..:|.||  .:.:..|.|:||||:::|:::.:  .|::. |:..|.|..
Mouse   499 AVFHGHYINGGFTVPFYKQLLGK--PIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEH 559

  Fly   932 SSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFS 996
            ::.|:....||||.|:::|||..|:.||::|..:::....|.....|.:||.:.::|...|..|.
Mouse   560 NAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFD 624

  Fly   997 NKELQILISGAEIPIDLEDLK-----KHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVT 1056
            .|||:::|.|.: .|||.|.|     |||......      :..||:.:|.||:.:|.:||:|||
Mouse   625 QKELELIIGGLD-KIDLNDWKSNTRLKHCVADSNI------VRWFWQAVETFDEERRARLLQFVT 682

  Fly  1057 SCSRPPLLGFKDLD-------PPFFIQNTGD--MERLPTASTCTNLLKLPPFKTVEQMREKLLYA 1112
            ..:|.||.|||.|.       |..|..:..|  .:.||.|.||.|.:.:||:::.|::.||||.|
Mouse   683 GSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTA 747

  Fly  1113 IQSGAGF 1119
            ::...||
Mouse   748 VEETCGF 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	123/375 (33%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	112/347 (32%)
Smurf1	XP_006504947.1	C2_Smurf-like	14..138	CDD:176028
		WW	236..267	CDD:197736
		WW	307..339	CDD:197736
		HECTc	399..754	CDD:238033	121/375 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810