Protein Alignment CG3356 and Ubr5

DIOPT Version :9

• Sequence 1: NP_611896.1
• Gene: CG3356 / 37876
• FlyBaseID: FBgn0034989
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: XP_006520242.1
• Gene: Ubr5 / 70790
• MGIID: 1918040
• Length: 2800
• Species: Mus musculus
• Alignment Length: 1152
• Identity: 245/1152 - (21%)
• Similarity: 408/1152 - (35%)
• Gaps: 366/1152 - (31%)

  Fly   160 IPLRMLETFTTVSSVQQYMKDEAV-LFQYMERVFGFLIAR-NYFVRLRRLLDDKCPPLDGETLHA 222
            ||..:..|:....::|.|::::.: .:.:|..|.....|: .|...|....|   |......|||
Mouse  1813 IPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSVMDSTEAQLRYGSALASAGD---PGHPNHPLHA 1874

  Fly   223 PSPLAE-----ALLQLLLRPLEVAKRA----------SAGGQMSSMSMAVCRNFTRDILATPHTD 272
            ....|.     |..:..||.||..:||          ||.|...:.::::.|:...:     |:|
Mouse  1875 SQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDE-----HSD 1934

  Fly   273 PLRYFVLP----CFALNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTTRMD 333
                 |||    |...:|.:.|..|:                          |.::..::.|.:|
Mouse  1935 -----VLPVLDVCSLKHVAYVFQALI--------------------------YWIKAMNQQTTLD 1968

  Fly   334 SIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDD 398
            :          ..|:|::...|                    |:|      |..|....|.:.||
Mouse  1969 T----------PQLERKRTREL--------------------LEL------GIDNEDSEHENDDD 1997

  Fly   399 DSEE---SEDEDEELPAA--------RTLDYDMEQTCRTSGELSVKERECLLESIAILNETERVD 452
            .|:.   ::.:|:.|||.        |..|......|.......|.    |.|:|.:.::.
Mouse  1998 TSQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVP----LAEAIPLADQP---- 2054

  Fly   453 FIVQQLDPHIENTHL-------IYA------LCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRA 504
               ..|.|:.....|       :|:      .| |....|..|...|...|:.|  |...|.:..
Mouse  2055 ---HLLQPNARKEDLFGRPSQGLYSSSAGSGKC-IVEVTMDRNCLEVLPTKMSY--AANLKNVMN 2113

  Fly   505 VWFK----------LA--AESTQLGFSAP-------LTLISKGVVPKHQGVDRTIPLLATF---C 547
            :..:          ||  |:|::.|.|||       .:|:::..:.:.:|     |.|.:|   |
Mouse  2114 MQNRQKKEGEEQSLLAEEADSSKPGPSAPDVAAQLKSSLLAEIGLTESEG-----PPLTSFRPQC 2173

  Fly   548 MLFGRLLPTLHDVEFVENKLLLQVHSTI--NHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPET 610
            ...|.::.  ||:.....:|.|::...:  ..|...|.||                |.||...|.
Mouse  2174 SFMGMVIS--HDMLLGRWRLSLELFGRVFMEDVGAEPGSI----------------LTELGGFEV 2220

  Fly   611 RSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFV------LNQIHTRDLRLGF---CPEDH 666
            :.  :.:|:.:       :|||:|:   :..|::.|.|      |.|...|.|...|   |....
Mouse  2221 KE--SKFRREM-------EKLRNQQ---SRDLSLEVKVDRDRDLLIQQTMRQLNNHFGRRCATTP 2273

  Fly   667 WTVTRLDLPL-DRPTD---------------------LPL----------THSSRLRGIRPFQPI 699
            ..|.|:.:.. |.|.:                     ||.          ||:|.::.:|. :..
Mouse  2274 MAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLDCIQNANKGTHTSLMQRLRN-RGE 2337

  Fly   700 RDFTRE---------------------DFENGPPMSTKQIR--SITILREIPFVVPFNKRVSILQ 741
            ||..||                     ||.....:.|:..|  |.....:.|..:|.::     |
Mouse  2338 RDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPDPLPAHR-----Q 2397

  Fly   742 SLVAASKMRVQGNMQAFLQ---------GPSVLITVRRSHLYEDAYDKLRP-------------- 783
            :|......|||....||..         .|:.|:.:..|.      |.||.
Mouse  2398 ALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASE------DSLRARVDEAMELIIAHGR 2456

  Fly   784 DNEPD-------LRFKFRIQ----------FVSSLGLDEA--GIDGGGVFREFLSELIKTAFDP- 828
            :|..|       |....::|          .|..:.|::.  |.|...:|           :.|
Mouse  2457 ENGADSILDLGLLDSSEKVQENRKRHGSSRSVVDMDLEDTDDGDDNAPLF-----------YQPG 2510

  Fly   829 NRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSD 893
            .|||:...      |..|.......:..    ||||||..:.:|.|..:.|....:..|.|:  .
Mouse  2511 KRGFYTPR------PGKNTEARLNCFRN----IGRILGLCLLQNELCPITLNRHVIKVLLGR--K 2563

  Fly   894 VDIHQLASLDPELYRNL--LYLKDYSGDV----SELNLDFTV---ASSSLGQTQIVELKPQGQSI 949
            |:.|..|..||.:|.:|  |.|...|.|.    |.::|.|.:   .....||   |||.|.|.:|
Mouse  2564 VNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---VELIPNGVNI 2625

  Fly   950 PVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLE 1014
            |||..|..||::..|::::.|...:..:|.||||.:|||...|...:.::.::|::|.. .::::
Mouse  2626 PVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCG-EVNVQ 2689

  Fly  1015 DLKKHCEYGGEFSPEHPSIVT----FWEVLEGFDDMQRRQLLKFVTSCSRPPLL--GFKDLD--- 1070
            .|.....:..|.......::.    ||.::|.....:|:.|:.|.||....|..  ||:.:.
Mouse  2690 MLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSIT 2754

  Fly  1071 --PPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
              ||       |.:.||||:||.:.|.:|.:.:.:.:::|||.||::
Mouse  2755 IRPP-------DDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT 2794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	100/404 (25%)
		HECTc	788..1119	CDD:214523	95/368 (26%)
Ubr5	XP_006520242.1	CUE_UBR5	184..230	CDD:270606
		ZnF_UBR1	1177..1244	CDD:197698
		PolyA	2391..2454	CDD:197769	14/73 (19%)
		HECTc	2469..2797	CDD:214523	94/360 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900