DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Herc4

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_084390.1	Gene:	Herc4 / 67345	MGIID:	1914595	Length:	1057	Species:	Mus musculus

Alignment Length:	668	Identity:	176/668 - (26%)
Similarity:	285/668 - (42%)	Gaps:	113/668 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 FKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLP----TLHDVEFVENKL 567
            ::.....:.:..:|...|..|.:.|.|..:.:.:.     ..|...|:|    :|.|||
Mouse   449 YRTGTRFSGVDMNAARLLFHKLIQPDHPQISQQVA-----ASLEKNLIPKLTSSLPDVE------ 502

  Fly   568 LLQVHSTINHVRLM-----------PFSIAEIIQMSKT-LK-----------DISMGLVELAFPE 609
            .|:.:.|:....||           ||..| ::.:.|. ||           .:.:.:||| |.|
Mouse   503 ALRFYLTLPECPLMSDCNNFTTIAIPFGTA-LVNLEKAPLKVLENWWSVLEPPLFLKIVEL-FKE 565

  Fly   610 TRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLG-FCPEDHWTVTRLD 673
            ...:|....|: |...:       :::|:.:.|:..:.||..:|..:.:.| ....|.:.:..:.
Mouse   566 VVVHLLKLYKI-GIPPS-------ERRIFNSFLHTALKVLEILHRVNEKTGQLIQYDKFYIHEVQ 622

  Fly   674 LPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVV---PF-- 733
            ..:|...|.......:..|:            |..:|          :|.|.:||..:   ||
Mouse   623 ELIDIRNDYINWVQQQAYGV------------DVSHG----------VTELADIPVTICTYPFVF 665

  Fly   734 --------NKRVSILQSLVAASKMRVQGNMQAFLQ-----GPSVLITVRRSHLYEDAYDKLRPDN 785
                    .:..::||..:|..:...|.....||.     .|.:::.|||.::..||.:.||...
Mouse   666 DAQAKTTLLQTDAVLQMQMAIDQAHRQNVSSLFLPVIESVNPCLILVVRRENIVGDAMEVLRKTK 730

  Fly   786 EPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKL--YPNPNVA 848
            ..|.:...::.||.     |..:|.|||.:||...:::...||..|.|....|::|  :.:..
Mouse   731 NIDYKKPLKVIFVG-----EDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKT-- 788

  Fly   849 DLFEDYEKHYYFIGRILGKSIYENLLVEL--PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLL 911
              |||.:. ::.||.|.|.:||...:|:|  |||.:  .||..:...:|  .|..|.|.:.|::.
Mouse   789 --FEDSDL-FHLIGVICGLAIYNFTIVDLHFPLALY--KKLLKRKPSLD--DLKELMPAVGRSMQ 846

  Fly   912 YLKDY-SGDVSE-LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRR 974
            .|.|| ..|:.| ..|:||:...:.|.|::.||...|....|...||.|::....||..|..:..
Mouse   847 QLLDYPEDDIEETFCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVAS 911

  Fly   975 HCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEV 1039
            ..:||..|...|...:.|.:|...|||.::.| ....|.::|:|:.||.||:..:||:|..||||
Mouse   912 LFDAFHAGFHKVCGGKVLLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGEYWADHPTIKIFWEV 975

  Fly  1040 LEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMER-LPTASTCTNLLKLPPFKTVE 1103
            .......:::|.|.|:|...|.|:||.|.|  ...||:||..|. ||.:.||.|||.||.:...|
Mouse   976 FHELPLEKKKQFLLFLTGSDRIPILGMKSL--KLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKE 1038

  Fly  1104 QMREKLLYAIQSGAGFEL 1121
            .:|.||:.||....||.|
Mouse  1039 TLRCKLIQAIDHNEGFSL 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	119/360 (33%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	111/337 (33%)
Herc4	NP_084390.1	RCC1 1	1..51
		RCC1	3..49	CDD:278826
		RCC1 2	52..101
		RCC1	52..99	CDD:278826
		RCC1 3	102..154
		RCC1	102..152	CDD:278826
		RCC1 4	156..207
		RCC1	157..205	CDD:278826
		RCC1 5	208..259
		RCC1	208..257	CDD:278826
		RCC1	260..308	CDD:278826
		RCC1 6	261..311
		RCC1 7	313..366
		RCC1	313..>343	CDD:278826
		HECTc	709..1055	CDD:238033	119/362 (33%)
		HECTc	735..1054	CDD:214523	110/335 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810