DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Herc6

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_080268.1	Gene:	Herc6 / 67138	MGIID:	1914388	Length:	1003	Species:	Mus musculus

Alignment Length:	788	Identity:	175/788 - (22%)
Similarity:	307/788 - (38%)	Gaps:	164/788 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 GDDDSEESEDEDEELPAARTLDYDMEQTCRTSGE--LSVKERECLLESIAILNETERVDFIVQQL 458
            |...|..|....:|.||..:     :.||..:.|  :.::.::....:.|....|.||.
Mouse   312 GRGPSHTSNPTHQEAPAENS-----DITCLLAAEDLVDIEVKDIFAGAHANFVTTRRVS------ 365

  Fly   459 DPHIENT----HLIYALCEICHNLM----IYNKH-----AVFEYKLLY--TLAFTPKFIRA---- 504
              |..:|    .::..:..|..:|:    ..||.     |..|..|::  :...|..|::.
Mouse   366 --HTRSTGVSMKILPEIIRINQSLVKKWRAANKRKDREGAKREISLIFSSSACLTASFLKKRDAG 428

  Fly   505 ------VWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFV 563
                  |..|||.:                 |.|....::.|..|.|.|:
Mouse   429 ENNLIDVDLKLARD-----------------VFKKLTTEKWISSLITTCL--------------- 461

  Fly   564 ENKLLLQV-HSTINHVRLMPFSI---AEIIQMSKTLKDIS---------MGLVELAFPETRSNLA 615
            |..||..: :|:.:...|:.|.:   ..|:|..|..|.::         ||...|||..|
Mouse   462 EEYLLRDLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFAKAIHKMGPQSLAFLRT----- 521

  Fly   616 NYRKVLGHTEADDKKLRHQKQIWANL----LNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPL 676
                                 .||:|    ||::|.:|.:.....::.|...|.:  :|.:.:.|
Mouse   522 ---------------------CWASLEVSSLNILVQMLKKAIISQIQYGVATEQY--ITNIKVLL 563

  Fly   677 D-----RPTDLPLTHS----SRLRGIRPF--QPIRDFTREDFENGPPMSTKQIRSITILREIPFV 730
            :     ...:..|..|    :.|.||..|  :..|.|.|.:     .:...:...:.:..:..||
Mouse   564 EVIKEVHKANCQLPESAFIINELSGIFNFDAEAGRMFIRHN-----DLDCTESSDMVVFSDFLFV 623

  Fly   731 VPFNKRVSILQSLVAASKMRVQGNMQAFLQ----GPSVLITVRRSHLYEDAYDKLRPDNEPDLRF 791
            .....::.:::   ..|.:::...:.||.:    .|.:::.||||||.||...:||...:.|||.
Mouse   624 FDLPSKIKLMK---CDSFVKLMSEVMAFPEKMSSPPYLILKVRRSHLVEDTLRQLRQVEDFDLRK 685

  Fly   792 KFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLF---ED 853
            :..:.|:     :|...:.|||..||...:.:...||....|       :||....:..|   ..
Mouse   686 QLSVGFI-----NEIRPEAGGVSSEFFHCIFEEMTDPKYEMF-------IYPEKGSSMWFPVNPK 738

  Fly   854 YEKHYYFI-GRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLL-YLKDY 916
            :||..||: |.:.|.|::...::.||.......||..:...::  .|..|...|.|||. .|...
Mouse   739 FEKSSYFLFGILCGLSLHNLKVINLPFPLALYKKLLNQKPSLE--DLKELSLPLGRNLQEVLNCE 801

  Fly   917 SGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRK 981
            :||:.||::.|::    ....:.|:|.|.|.|:||..:|:.:|:....||..|:.|:.....|.:
Mouse   802 AGDIEELHMYFSI----YWDQKDVDLIPDGISVPVNETNKRDYVSKYVDYIFNISIKTIYEEFHR 862

  Fly   982 GLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDM 1046
            |...|...:.:..|..:||...|.| ....|.:..:.:.:|...:...||:|:.||:........
Mouse   863 GFYKVCNWDIIRQFQPEELMTAIIG-NATCDWKQFENNSKYKDGYDKSHPTILLFWKAFHDLTLD 926

  Fly  1047 QRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLY 1111
            ::::.|.|:|.|.|..:.|.::....|....|...|..|.:.||..:|.||.:.::.:|:|.|..
Mouse   927 EKKKFLLFLTGCDRLHVKGLQNEGIVFRCSETFSEEDNPRSLTCHRMLDLPKYSSMRRMKEALQV 991

  Fly  1112 AIQSGAGF 1119
            ||.:..||
Mouse   992 AINNSTGF 999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	99/359 (28%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	87/335 (26%)
Herc6	NP_080268.1	RCC1 1	40..91
		RCC1	40..89	CDD:278826
		RCC1 2	92..144
		RCC1	92..142	CDD:278826
		RCC1	145..195	CDD:278826
		RCC1 3	146..197
		RCC1_2	183..211	CDD:290274
		RCC1 4	199..252
		RCC1_2	237..266	CDD:290274
		RCC1 5	253..303
		RCC1	253..300	CDD:278826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..281
		chaperonin_like	<570..>652	CDD:295468	14/89 (16%)
		HECTc	658..999	CDD:238033	97/359 (27%)
		HECTc	682..999	CDD:214523	87/335 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810