Protein Alignment CG3356 and Smurf2

DIOPT Version :9

• Sequence 1: NP_611896.1
• Gene: CG3356 / 37876
• FlyBaseID: FBgn0034989
• Length: 1122
• Species: Drosophila melanogaster
• Sequence 2: NP_079757.2
• Gene: Smurf2 / 66313
• MGIID: 1913563
• Length: 748
• Species: Mus musculus
• Alignment Length: 617
• Identity: 169/617 - (27%)
• Similarity: 271/617 - (43%)
• Gaps: 110/617 - (17%)

  Fly   536 VDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTI---NHVRLMPFSIAEIIQMSKTLKD 597
            ||...|:..|    .|.......|....|.::..|.|...   .|:...| .:.|..:...|.:.
Mouse   206 VDENTPITGT----NGATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPP-DLPEGYEQRTTQQG 265

  Fly   598 ISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQI-------HTR 655
                  ::.|..|::.::.:               |..::..:|.|:....|..:       :|.
Mouse   266 ------QVYFLHTQTGVSTW---------------HDPRVPRDLSNINCEELGPLPPGWEIRNTA 309

  Fly   656 DLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRS 720
            ..|:.|...::.|....|..|.....|.|...::|:..:..|.:            |:.......
Mouse   310 TGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVV------------PLCPDDTEC 362

  Fly   721 ITILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYD---KLR 782
            :|        ||..||     .||...|:..|...|...|.....|.|.|..::|::|.   |:|
Mouse   363 LT--------VPRYKR-----DLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMR 414

  Fly   783 P-DNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDN--KLYPN 844
            | |....|..|||         .|.|:|.|||.||:|..|.....:|..|.|..:.|:  .|..|
Mouse   415 PKDLWKRLMIKFR---------GEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQIN 470

  Fly   845 PNVADLFEDYEKHYYFIGRILGKSIYENLLVE----LPLAEFFLTKLAGKYSDVDIHQLASLDPE 905
            |:.| :..::..:::|:|||:|.:::....::    ||    |..:|.||...:|..:|  :||:
Mouse   471 PDSA-VNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLP----FYKQLLGKSITLDDMEL--VDPD 528

  Fly   906 LYRNLLYL--KDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKL 968
            |:.:|:::  .|.:|   .|:..|.|..::.|:....||||.|:|||||..|:.||::|..:::.
Mouse   529 LHNSLVWILENDITG---VLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRF 590

  Fly   969 NVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLK-----KHCEYGGEFSP 1028
            ...|.....|.:||.:.|:|...|..|..|||:::|.|.. .||:.|.|     |||      :|
Mouse   591 LRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLG-KIDVSDWKVNTRLKHC------TP 648

  Fly  1029 EHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLD----PPFFIQNTGD--MERLPTA 1087
            :...:..||:.:|.||:.:|.:||:|||..||.||.|||.|.    |..|..:..|  ...||.|
Mouse   649 DSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKA 713

  Fly  1088 STCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            .||.|.:.:||:::.|::.||||.||:...||
Mouse   714 HTCFNRIDIPPYESYEKLYEKLLTAIEETCGF 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	128/377 (34%)
		HECTc	788..1119	CDD:214523	117/349 (34%)
Smurf2	NP_079757.2	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736	5/51 (10%)
		WW	298..330	CDD:197736	5/31 (16%)
		HECTc	393..745	CDD:238033	126/377 (33%)
		HECTc	420..745	CDD:214523	117/350 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810