DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and HACE1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens

Alignment Length:	1066	Identity:	240/1066 - (22%)
Similarity:	411/1066 - (38%)	Gaps:	294/1066 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 IPLRMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIARNY-FVRLRRLLDDKCPPLDGETLH-- 221
            :|:.|.:...:||.:....|.:.                || |.|::|.|           ||
Human    35 MPMVMADQHRSVSELLSNSKFDV----------------NYAFGRVKRSL-----------LHIA 72

  Fly   222 APSPLAEALLQLLLR-------------PLEVAKRASAGGQMSSMS--------MAVCRNFTRDI 265
            |.....|.|:.||.:             ||.:|.|   .||...||        :.:|.|   :.
Human    73 ANCGSVECLVLLLKKGANPNYQDISGCTPLHLAAR---NGQKKCMSKLLEYSADVNICNN---EG 131

  Fly   266 LATPHTDPLRYFVLPCFALNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTT 330
            |...|.            |.|:...:|    |:|.::.....:.:....:.: |....:.|||||
Human   132 LTAIHW------------LAVNGRTEL----LHDLVQHVSDVDVEDAMGQTA-LHVACQNGHKTT 179

  Fly   331 RMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYV------RLIAEMMPNILQLPKSTLRGHANA 389
                  ...||:|...::|..::  ..:||   |.      |..|:::         .|||....
Human   180 ------VQCLLDSGADINRPNVS--GATPL---YFACSHGQRDTAQIL---------LLRGAKYL 224

  Fly   390 PHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELSVKERECLLESIAILNETERV-DF 453
            |              |::...|....:.....:||    |:.::....|.::|..:.:.|.: :.
Human   225 P--------------DKNGVTPLDLCVQGGYGETC----EVLIQYHPRLFQTIIQMTQNEDLREN 271

  Fly   454 IVQQLDPHI----ENTHL--IYALCEIC----HNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFK 508
            :::|:..|:    |:.:|  :.:|.|:.    |.|:..:.:...:.|.|         :|.|  :
Human   272 MLRQVLEHLSQQSESQYLKILTSLAEVATTNGHKLLSLSSNYDAQMKSL---------LRIV--R 325

  Fly   509 LAAESTQLGFSAPLTLISKGV----VPKHQ----------GVDRTIPLLATFCMLFGRLLPTLHD 559
            :.....::|.|:|...|..|.    .|:.|          .:|..:.|:||      .|:....|
Human   326 MFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIAT------ELMKNKRD 384

  Fly   560 VEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHT 624
            ...:.:.||.|.....:...:.||                    |...|.:..||:.     |..
Human   385 STEITSILLKQKGQDQDAASIPPF--------------------EPPGPGSYENLST-----GTR 424

  Fly   625 EADDKKLRHQKQIWANLLNVVVFVLNQIH------------------TRDLRLGF-CPEDHWTVT 670
            |:....|..:::..|:..:|:....|::.                  |....:.| |..|.
Human   425 ESKPDALAGRQEASADCQDVISMTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDE---- 485

  Fly   671 RLDLPLDRPTDLPLTH----------SSRLRGIRPFQPIRD---FTREDFENGPPMSTKQIRSIT 722
            .|...::|...:...|          .||...|...||.:|   :..|...:|.|.|....|
Human   486 VLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHR--- 547

  Fly   723 ILREIPFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEP 787
                     |.|:                           :.::.|.|..::..:.:.:...|..
Human   548 ---------PVNE---------------------------NDILLVHRDSIFRSSCEVVSKANCA 576

  Fly   788 DLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLY-PNPNVADLF 851
            .|:....::|....|:      |.||.||:...|.....:|:...|..:.|...: ||.| :.:.
Human   577 KLKQGIAVRFHGEEGM------GQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSN-SYVN 634

  Fly   852 EDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAG---KYSDVDIHQLASLDPELYRNLLYL 913
            .|:..::.|.|:|||.::....||.:.....|...:.|   .|.||     ||:|||..:||.::
Human   635 PDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDV-----ASIDPEYAKNLQWI 694

  Fly   914 KDYSGDVSELNLD--FTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHC 976
            .|  .|:|:|.|:  |:|.:...|..:.|.|||.|.||.||.:|:.||:||:.:.::...|:...
Human   695 LD--NDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQI 757

  Fly   977 NAFRKGLSNVLPIEWLYMFSNKELQILISGAEIP-IDLEDLKKHCEYGGEFSPEHPSIVTFWEVL 1040
            |||.:|....:|...:.:|...||::|:||  :| ||:.|..|:.||...:..|.|.|..||||:
Human   758 NAFLQGFHMFIPPSLIQLFDEYELELLLSG--MPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVV 820

  Fly  1041 EGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQN--------TGDMERLPTASTCTNLLKLP 1097
            |.....:|..||:|||..||.|..||.::.....:||        |.::  |||:|||.|:||||
Human   821 EDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNL--LPTSSTCINMLKLP 883

  Fly  1098 PFKTVEQMREKLLYAIQSGA-GFELS 1122
            .:.:.|.::::||.|:..|: |:.::
Human   884 EYPSKEILKDRLLVALHCGSYGYTMA 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	118/369 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	114/346 (33%)
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894	64/335 (19%)
		ANK 1	64..93		9/39 (23%)
		ANK repeat	66..95	CDD:293786	9/39 (23%)
		ANK	92..217	CDD:238125	32/167 (19%)
		ANK repeat	97..128	CDD:293786	8/33 (24%)
		ANK 2	97..126		8/31 (26%)
		ANK repeat	130..161	CDD:293786	7/46 (15%)
		ANK 3	130..159		7/44 (16%)
		ANK repeat	163..194	CDD:293786	10/37 (27%)
		ANK 4	163..192		9/35 (26%)
		ANK 5	196..226		9/57 (16%)
		ANK repeat	196..221	CDD:293786	7/38 (18%)
		ANK 6	228..257		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433		9/59 (15%)
		HECTc	554..903	CDD:238033	116/366 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810