DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and HECW2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_006712709.1	Gene:	HECW2 / 57520	HGNCID:	29853	Length:	1579	Species:	Homo sapiens

Alignment Length:	461	Identity:	134/461 - (29%)
Similarity:	216/461 - (46%)	Gaps:	71/461 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   675 PLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSI 739
            |:..|.:.|.|..:..|...|:       :.|||       .::|:.
Human  1175 PVSSPQNSPGTQRANARAPAPY-------KRDFE-------AKLRNF------------------ 1207

  Fly   740 LQSLVAASKMRVQGNMQAFLQGPSVL-ITVRRSHLYEDAYDKLRPDNEPDL-RFKFRIQFVSSLG 802
                  ..|:..:|    :.|||..| :.:||.||.|||::::...:..|| |.|..:.||.
Human  1208 ------YRKLETKG----YGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG--- 1259

  Fly   803 LDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED-YEKHYYFIGRILG 866
              |.|:|..|..|||...:.:..|:|..|.|..:.::......:....|.| :.:.:.|.|||||
Human  1260 --EEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILG 1322

  Fly   867 KSIYENLLVEL----PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE-LNLD 926
            .::....|::.    |..:..|..|.      |:..|..||.|.:::|.::||  .|:.: |:|.
Human  1323 LALIHQYLLDAFFTRPFYKALLRILC------DLSDLEYLDEEFHQSLQWMKD--NDIHDILDLT 1379

  Fly   927 FTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEW 991
            |||.....||....||||.|.:||||..|:.||::.:..:::...:.:...:..:|...|:....
Human  1380 FTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARL 1444

  Fly   992 LYMFSNKELQILISG-AEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFV 1055
            :.:|..:||:::|:| ||  |||.|.:.:.||.|.:...|..|..||..:|.|::.||.:||:||
Human  1445 VSVFDARELELVIAGTAE--IDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFV 1507

  Fly  1056 TSCSRPPLLGFKDL---DPP--FFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
            |..|..|..||..|   :.|  |.::..|.:..||.|.||.|.|.|||:.:...:.||||.|::.
Human  1508 TGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1572

  Fly  1116 GAGFEL 1121
            .:.|.|
Human  1573 TSTFGL 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	116/366 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	109/343 (32%)
HECW2	XP_006712709.1	HECW_N	45..164	CDD:318711
		C2_NEDL1-like	185..321	CDD:176073
		NESP55	<471..638	CDD:115071
		PHA03169	591..>801	CDD:223003
		WW	816..845	CDD:306827
		WW	994..1023	CDD:306827
		HECTc	1223..1577	CDD:238033	117/368 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810