DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and hace1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_701235.5	Gene:	hace1 / 572430	ZFINID:	ZDB-GENE-110411-52	Length:	905	Species:	Danio rerio

Alignment Length:	840	Identity:	199/840 - (23%)
Similarity:	339/840 - (40%)	Gaps:	186/840 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   414 RTLDYDME-QTCRTSGELSVKERECLLESIAILNETERVDFIVQQLDPHIENTHLIYALCEICHN 477
            |.|:|:.: ..|...|..::       ..:|:...||.:..:||    |:.|..:..|:.:...:
Zfish   121 RLLEYNADVNICNNEGLTAI-------HWLAVNGRTELLHDLVQ----HVTNVDVEDAMGQTALH 174

  Fly   478 LMIYNKHAVFEYKLLYTLA--FTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRTI 540
            :...|.|......||.:.|  ..|....|.....|....|...:..|.|.....:|...||   .
Zfish   175 VACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDRNGV---T 236

  Fly   541 PL-------LATFCMLF----GRLLPTLHDVEFVEN-----KLLLQV------HSTINHVRLMPF 583
            ||       ....|.:.    |||..||  ::..:|     .:|.||      .:..|:.|::.
Zfish   237 PLDLCVQGGYGETCEILIQHHGRLFQTL--IQMTQNDDIKENMLRQVLEHVSQQNDSNYQRILT- 298

  Fly   584 SIAEI----------------IQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLR 632
            |:||:                :|....|:.|.:.........:..|..|.....|:.....:..:
Zfish   299 SLAEVATTNGHKLLSLSSNFEVQTKSLLRIIRIFCHVFCLGPSSPNNGNDMGYNGNKTPRSQVFK 363

  Fly   633 HQKQIWANLLNVVVFVLNQIH------TR-----DLRLGFCPE---DHWTVTRLDLPLDRPTDLP 683
            ..:.:|.:|...:|.:..::.      ||     |:...|..:   ||      .:..:.| .|.
Zfish   364 PLELLWHSLDEWLVLISTELEKEITDTTRSSSGNDIASLFLKKQEVDH------SVSSENP-QLL 421

  Fly   684 LTHSSRLRGIRPFQPIRDFTREDFENGPPM-------------------STKQIRSITILREIPF 729
            |..||.::           |.|.:.:|..:                   |.:....:|..|.|.|
Zfish   422 LDASSVMK-----------TPEVYADGQDVISMIANRLSAVIQAFYMCCSCQMPHGMTSPRFIEF 475

  Fly   730 VVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVL---ITVRRSHLYEDA----YDKL------ 781
            |.   |...:|:..|..:...:..:....|:.|.::   :.:.:...::|.    |:.|
Zfish   476 VC---KHDEVLKCFVTRNPKIIFNHFHFLLECPELMSRFMHIIKGQPFKDRCEWFYEHLLAGQPD 537

  Fly   782 -----RPDNEPDL-------RFKFRIQFVSSLGLD------------EAGIDGGGVFREFLSELI 822
                 ||.||.|:       .|:...:.||....:            |.|: |.||.||:...|.
Zfish   538 SDMVHRPVNENDILLVHRDSLFRSSCEVVSKSSNEKLKQGIAVRFHGEEGM-GQGVVREWFDILS 601

  Fly   823 KTAFDPNRGFFMVTTDNKLY-PNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTK 886
            ....:|:...|..:.|...: ||.| :.:..|:..::.|.|:|||.::|...||.:.....|...
Zfish   602 NEIINPDYALFTQSADGTTFQPNSN-SSVNPDHLNYFRFAGQILGLALYHRQLVNIYFTRSFYKH 665

  Fly   887 LAG---KYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLD--FTVASSSLGQTQIVELKPQG 946
            :.|   .|.||     :|:|||..:||.::.|  .|:|:|.|:  |:|.:...|..:.|.|||.|
Zfish   666 ILGIPVSYQDV-----SSIDPEYAKNLQWILD--NDISDLGLELTFSVETDVFGTMEEVPLKPGG 723

  Fly   947 QSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIP- 1010
            .:|.||..|:.||:||:.:.::...|:...|||.:|....:|...:.:|...||::|:||  :|
Zfish   724 TTIQVTQDNKEEYVQLVTELRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSG--MPE 786

  Fly  1011 IDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFI 1075
            ||:.|.|::.||...:..:.|.|..||||:|.....:|..||:|||..||.|..||.      |:
Zfish   787 IDVMDWKRNTEYTSGYDLQEPVIQWFWEVVENLTQEERVLLLQFVTGSSRVPHGGFA------FL 845

  Fly  1076 QNTGDMER------------LPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGA-GFELS 1122
            .....:::            |||:|||.|:||||.:.:.:.:|::||.|:..|: |:.::
Zfish   846 MGGSGLQKFTVAAVPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGSYGYTMA 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	121/407 (30%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	113/369 (31%)
hace1	XP_701235.5	ANK repeat	71..100	CDD:293786
		ANK	71..98	CDD:197603
		Ank_2	74..199	CDD:289560	18/88 (20%)
		ANK	97..222	CDD:238125	22/111 (20%)
		ANK repeat	102..133	CDD:293786	3/11 (27%)
		ANK repeat	135..166	CDD:293786	8/41 (20%)
		Ank_2	140..227	CDD:289560	19/97 (20%)
		ANK repeat	168..199	CDD:293786	5/30 (17%)
		ANK repeat	201..226	CDD:293786	5/24 (21%)
		Ank_4	204..254	CDD:290365	10/52 (19%)
		ANK repeat	233..261	CDD:293786	7/30 (23%)
		HECTc	550..899	CDD:238033	111/365 (30%)
		HECTc	575..898	CDD:214523	108/339 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910