DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3356 and SMURF1

DIOPT Version :9

Sequence 1:NP_611896.1 Gene:CG3356 / 37876 FlyBaseID:FBgn0034989 Length:1122 Species:Drosophila melanogaster
Sequence 2:NP_065162.1 Gene:SMURF1 / 57154 HGNCID:16807 Length:757 Species:Homo sapiens


Alignment Length:385 Identity:126/385 - (32%)
Similarity:202/385 - (52%) Gaps:45/385 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   759 LQGPSV---LITVRRSHLYEDAYD---KLRP-DNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFRE 816
            ||.|..   .|.|.|..::|::|.   |:|| |.:..|..|||         .|.|:|.|||.||
Human   391 LQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFR---------GEEGLDYGGVARE 446

  Fly   817 FLSELIKTAFDPNRGFFMVTTDN--KLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPL 879
            :|..|.....:|..|.|..:|||  .|..||: :.:..|:..:::|:|||:|.:::....:....
Human   447 WLYLLCHEMLNPYYGLFQYSTDNIYMLQINPD-SSINPDHLSYFHFVGRIMGLAVFHGHYINGGF 510

  Fly   880 AEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE-LNLDFTVASSSLGQTQIVELK 943
            ...|..:|.||  .:.:..|.|:||||:::|:::.:  .|::. |:..|.|..::.|:....|||
Human   511 TVPFYKQLLGK--PIQLSDLESVDPELHKSLVWILE--NDITPVLDHTFCVEHNAFGRILQHELK 571

  Fly   944 PQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAE 1008
            |.|:::|||..|:.||::|..:::....|.....|.:||.:.::|...|..|..|||:::|.|.:
Human   572 PNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLD 636

  Fly  1009 IPIDLEDLK-----KHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKD 1068
             .|||.|.|     |||......      :..||:.:|.||:.:|.:||:|||..:|.||.|||.
Human   637 -KIDLNDWKSNTRLKHCVADSNI------VRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKA 694

  Fly  1069 LD-------PPFFIQNTGD--MERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            |.       |..|..:..|  .:.||.|.||.|.:.:||:::.|::.||||.|::...||
Human   695 LQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGF 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3356NP_611896.1 HECTc 766..1120 CDD:238033 123/375 (33%)
HECTc 788..1119 CDD:214523 112/347 (32%)
SMURF1NP_065162.1 C2_Smurf-like 14..138 CDD:176028
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..237
WW 236..267 CDD:197736
WW 307..339 CDD:197736
HECTc 399..754 CDD:238033 121/375 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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