DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and plekha5

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_021330752.1	Gene:	plekha5 / 567300	ZFINID:	ZDB-GENE-041210-25	Length:	1398	Species:	Danio rerio

Alignment Length:	846	Identity:	157/846 - (18%)
Similarity:	259/846 - (30%)	Gaps:	279/846 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DRDTVIRKAALERQKRNEL-RQKENGAVVLQSYARSFI-HRQRRKRAEREVFDIYLM---GHKDG 83
            |:|.|..:...||...|.. |||:....:||.....|: .:...|.|.::..|.||:   |||..
Zfish   343 DKDRVSMQKDGERFSENYTHRQKDGERYMLQKDLEKFVLQKDGEKYAVQKEGDKYLLQKDGHKYT 407

  Fly    84 IVEDESLTFLLRRLNFFYSIREA-----KDS------------------------------ERLI 113
            :.:|.....|.|.|..:...::|     ||:                              ||.:
Zfish   408 VHKDGDKYTLQRELEMYNPPKDAEKIPQKDARFSLVQKELEKPVPPPRSEEKYGFQKEGTIERPL 472

  Fly   114 EVCQQILRQPA------------RLLQHS-----------SPDSLWLLRLCKLLDTCLLQLSLSH 155
            .....|..|||            |::|..           ||..|..:|           .|:..
Zfish   473 TKINSIKLQPAQAAAIAAAVSSSRMMQKQVNGSGERAGDRSPGDLSTVR-----------TSVPP 526

  Fly   156 TAQAI--PLRMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDKCPPLDGE 218
            ..|..  |.|.|...:::..::|:::..                     |.|...||.......:
Zfish   527 PTQPAPEPERSLSRTSSMQQLEQWVRTH---------------------RTRAPDDDTRSITSYQ 570

  Fly   219 TLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFA 283
            ||....|...|         ::..|...|                            |..||...
Zfish   571 TLPRNMPSHRA---------QIVPRYPEG----------------------------YRTLPRNM 598

  Fly   284 LNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLD 348
            |..| ....:..|:||.      |...||..:|           ::.|.|:::..:.........
Zfish   599 LRPD-SICSVAGSVYDR------ALQPSTQEKR-----------RSIRDDTMWQLYEWQQRQAHS 645

  Fly   349 RRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRG-HANAPHRHRDGDDDSEESED------- 405
            |....|| .||..   :..|||.:|.  .....:|.| |..:|:|..:.|..||.|..
Zfish   646 RLGYGTL-PSPKT---MGQIAESIPT--SPSHGSLAGYHTFSPNRPLNPDSRSELSSPVFRGDVT 704

  Fly   406 -EDEELPAARTLDYDMEQTC--------------RTSGELS-----VKERECLLESIAILNETER 450
             |....|......|..|:..              :|..||:     ::.::..|.|   |.|...
Zfish   705 IERRHRPHLSKYSYPAERRAAPPAQNITAQSLQGKTPEELTLLLIKLRRQQAELNS---LREHTL 766

  Fly   451 VDFIVQQLDP----------HIENTHLIYALCEICHN-LMIYNKHAVFEYKL----LYTLAFTPK 500
            ...:...||.          |::. :|:|...::..| .:|:..|.:.|...    ||....:|:
Zfish   767 AQLMQLNLDATNPKSEILSHHLQR-NLMYLDSQMKENEPIIFMIHTMIENSAPRPQLYQQQMSPE 830

  Fly   501 FIRAVWFKLAAESTQLGFSAPLT-LISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVE 564
            ..|...:....|  :|...|.|: |..:..|.:.|                ...|..||..:...
Zfish   831 EYRENTYMYRPE--ELDVDAKLSRLCEQDKVVRTQ----------------EEKLQQLHREKHTL 877

  Fly   565 NKLLLQVHSTINHVRLMPFSIAEIIQ--------MSKTLKDISMGLVEL--AFPE---------- 609
            ...||.....|......|.::..::|        :..|.:::|....||  ::.|
Zfish   878 ETALLSASQEIEMSSENPAAVQSVVQQRDVLQSGLLSTCRELSRVSTELERSWREYDRLEADVTL 942

  Fly   610 TRSNLANYRKVLGHTEADDKKLRH---QKQIWANLLNVVVFV------------------LNQIH 653
            .::||....:.||..:.:....:|   ||::| .:.:|:..:                  |:.:|
Zfish   943 AKTNLLEQLEALGSPQTEPPSQKHVQIQKELW-RIQDVMEALSKNKPKRNPEPSFPGANPLSTLH 1006

  Fly   654 TRDLRLGFCPEDHWTVTRLDLPL-----DRPTDLP---LTHSSRLRGIRPFQPIRDFTREDFENG 710
            ..:..:    :......|..||.     |||..||   ..|::|....|| :..:...|.....|
Zfish  1007 KSEDSV----DSSCVPPRPPLPYSYEGGDRPPPLPNPGQPHTTRTTPHRP-EDRKTAQRNGTHTG 1066

  Fly   711 P 711
            |
Zfish  1067 P 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523
plekha5	XP_021330752.1	WW	13..42	CDD:306827
		WW	58..87	CDD:306827
		PH_PEPP1_2_3	177..280	CDD:270068
		SMC_N	822..>983	CDD:330553	33/179 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900