DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and wwc3

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001103940.1	Gene:	wwc3 / 566492	ZFINID:	ZDB-GENE-070209-229	Length:	1148	Species:	Danio rerio

Alignment Length:	887	Identity:	193/887 - (21%)
Similarity:	284/887 - (32%)	Gaps:	270/887 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRRKRAE---------REVFD 74
            |...|.|:.:.|......|.|.||:.||.|...||...|.....|...:.:         |.:..
Zfish   171 AEIACRRERLSRLKQELAQMRQELQYKEMGVETLQEIDRKMSSSQTNYKLDEAQAIFSELRSIKK 235

  Fly    75 IYLMGHKDGIVEDESLTFLLRRLNFFYSIRE-AKDSERLIEVC--QQILR---QPARLLQHSSPD 133
            ....|.|:.....:||..|  .|||..||.| ..::|.|.:.|  ||...   |...:.:..|.:
Zfish   236 AISTGEKERQDLIQSLAKL--TLNFCDSINEVTNNAESLADSCSVQQYTDAGCQTDLMGEFGSQE 298

  Fly   134 SLWLLRLCKL-------------LDTCLLQL---SLSHTAQAIP-------LRMLETF---TTVS 172
            |..|....||             :...|.||   |.|..|:|..       ||..||.   .|:.
Zfish   299 SSLLADRVKLSWQYEEAKKKMSSIQHQLAQLDSESWSGRAEADRDWDCLQLLREKETLLQELTLL 363

  Fly   173 SVQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDKCPPLDGETLHAPSPLAEA-----LLQ 232
            |.||:..|  .|.|..|             ..|||.|        |...|.|..::.     |||
Zfish   364 SQQQHSSD--TLLQLQE-------------EKRRLQD--------EVQRAHSAQSQGANQRILLQ 405

  Fly   233 ----LLLRPLEVAKR-----------------------------------ASAGGQMSSMSMAVC 258
                :|:|.||.|.|                                   ||:.|.:||:|
Zfish   406 EKRNVLMRQLEEATRITTYLHSQLKSLSASNLTVSSSSSRGSLASSRGSLASSRGSLSSVS---- 466

  Fly   259 RNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGV 323
              || ||...|..|            ..:...|:|..|....|    |.||.|:.|.     ||.
Zfish   467 --FT-DIYGLPQYD------------RTEGSSDVLDPSFRYLL----PLESHSSGSA-----YGP 507

  Fly   324 ETGHKTTR-MDSIFSSFLLNSLMVLDRRQLATLHQSP------------LLVIYVRLIAEMMPNI 375
            :..|.|.: :.|:.|...|:||...........|.:|            :.|....|:||.:...
Zfish   508 KRSHDTPQSLTSLSSRSSLSSLSPPSSPMDTPYHSAPQDCPLAQMTEEYMEVASRGLLAEGLRTQ 572

  Fly   376 LQLPK-STLRG----------HANAPHRHRDGDDDSEESEDEDEELPAARTLD-YDMEQTCRTSG 428
            .|..: :||.|          |......|||.......|.       ...||. ....:|.|.:.
Zfish   573 SQAQQHTTLSGDGEVGIAATAHLLEGKSHRDAALQGTHSS-------TGVTLRCKSASRTSRRAR 630

  Fly   429 ELSVKERECLLE---------SIAILNETERVDFIVQQLDPHIENTHLIYALCEICHNLMIYNKH 484
            .:|....|.:|.         |.:...|:|.|.|.........|..|:...|        :|:.:
Zfish   631 RVSAGVNEDVLATDSGVFEAWSRSRTEESEEVSFAQDVTVAVSEPVHIQIGL--------LYDSN 687

  Fly   485 AVFEYKLLYTLA---FTPKFIRAVW-------------------FKLAAESTQL------GFSAP 521
            :  .:.||:.|.   .:...||..|                   :...|:..|.      .|..|
Zfish   688 S--RFLLLHVLQMRNLSKASIRDRWKVFVKVHVLPMDSSRPCTYYCCKAQEPQSLLSFNESFRIP 750

  Fly   522 LTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHD----VEFVENKLLLQVHSTINHVRLMP 582
            |::...|.......:....||...  .|.|....:|.|    .|.:...|.:|.|||.||   .|
Zfish   751 LSVGGPGAHALQFSLSTLGPLAQE--ELLGSAQVSLTDCVGSTEMLFQWLKVQFHSTENH---RP 810

  Fly   583 ----FSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRH-----QKQIW 638
                .|....|...:..|:...|.:|::   ..|:|...:|.|..:|.:.::...     .::.|
Zfish   811 EHRRLSQPNRIMDEEEEKNEGQGKLEVS---VVSHLEEMKKELQRSEEELERKEEPGEAVSERSW 872

  Fly   639 ------ANLLNVVVFVLNQIHTRDLRLGFCPE----DHWTVT---RLDLPLDRPTDLPLTHSSRL 690
                  :...|...||:.           |||    :...:|   |...|.:|...:.:..::..
Zfish   873 QAESVDSGCSNSTAFVIP-----------CPESLCGEGICLTSGRRCLQPAERNPIIKVDKATNT 926

  Fly   691 RGIRPFQPIRDFTRE---DFENGPPMSTKQIRSITILREIPF 729
            .|:.. :|:|...:|   .:.:..|.    :||.||:|...|
Zfish   927 EGVFA-EPMRMRPKERTGRWGHSSPF----MRSSTIVRSQTF 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523
wwc3	NP_001103940.1	WW	17..46	CDD:278809
		WW	64..93	CDD:278809
		C2_Kibra	677..800	CDD:176062	23/134 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900