DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and trip12

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_005159283.1	Gene:	trip12 / 564866	ZFINID:	ZDB-GENE-041111-262	Length:	2096	Species:	Danio rerio

Alignment Length:	488	Identity:	131/488 - (26%)
Similarity:	212/488 - (43%)	Gaps:	110/488 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   722 TILREI----PFVVPFNKRVSI-----------LQSLVAASKMRVQGNMQAFLQGPSV---LITV 768
            |.|.|:    ||..||:.|..:           :|.|:..:....|.:.|.....|.:   ..|:
Zfish  1632 TWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDSQDSRVAPRLDRKKRTI 1696

  Fly   769 RRSHLYEDAYDKLRPDNEPDL---RFKFRIQFVSSLGLDEAGIDGGGVFREFLS----ELIK--- 823
            .|..|.:.|...::     ||   |....||:.:.:|      .|.|..:||.:    ||.:
Zfish  1697 NRDELLKQAESVMQ-----DLGSSRAMLEIQYENEVG------TGLGPTQEFYALVSQELQRADL 1750

  Fly   824 --------TAFDP-------------NRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRILGK 867
                    |..:|             :||.|.|.......| .::|.:    :..:.|:|:::.|
Zfish  1751 GLWRGEEVTLSNPKVGSQEGTKYMFSSRGLFAVPFGRTTKP-AHIAKI----KMKFRFLGKLMAK 1810

  Fly   868 SIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKD----------------- 915
            :|.:..|::|||...|...:....|.:..|.|.::||.:.:::.:|:|
Zfish  1811 AIMDFRLLDLPLGLPFYKWMLRHESSISSHDLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRE 1875

  Fly   916 ----------YSG-DVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLN 969
                      .:| .|.:|.||||     |.....:|||..|:.:|||..|..:||:|:..:.||
Zfish  1876 TLQQALESLNMNGCSVEDLGLDFT-----LPGFPNIELKKGGKDVPVTIHNLEDYLRLVVYWTLN 1935

  Fly   970 VQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPI-DLEDLKKHCEYGGEFSPEHPSI 1033
            ..:.|...:||:|..:|.|:..|..|..:||..|:.|::... |::.|.:.|.....::.:..::
Zfish  1936 EGVLRQFESFREGFESVFPLHHLQYFYPEELDQLLCGSKSESWDVKTLMECCRPDHGYTHDSRAV 2000

  Fly  1034 VTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFI--------QNTGDMERLPTASTC 1090
            ...:|||..||..|:|..|:|||...|.|:.||:.|:||..|        :|..|.  ||:..||
Zfish  2001 RFLFEVLSSFDAEQQRLFLQFVTGSPRLPVGGFRSLNPPLTIVRKTFESTENPDDF--LPSVMTC 2063

  Fly  1091 TNLLKLPPFKTVEQMREKLLYAIQSG-AGFELS 1122
            .|.||||.:.::|.||||||.|.:.| ..|.||
Zfish  2064 VNYLKLPDYSSIEIMREKLLIAAREGQQSFHLS 2096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	115/422 (27%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	111/399 (28%)
trip12	XP_005159283.1	WWE	842..907	CDD:280915
		HECTc	1693..2094	CDD:238033	115/423 (27%)
		HECTc	1711..2090	CDD:214523	110/396 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900