DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and magi2a

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001314782.1	Gene:	magi2a / 564112	ZFINID:	ZDB-GENE-050810-4	Length:	1503	Species:	Danio rerio

Alignment Length:	267	Identity:	53/267 - (19%)
Similarity:	91/267 - (34%)	Gaps:	81/267 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 ENKLLLQVHS----TINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGH- 623
            |..|:::::.    |::|.           |:.:.||:..:|        |.:.|...|...||
Zfish   635 EGDLIVEINQQPALTLSHT-----------QVVELLKECPIG--------TEATLVIQRGGTGHF 680

  Fly   624 --TEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTH 686
              .:...:.|.|...:.:...::.|..|.  |:       .|..||. :..:..|.:|....|..
Zfish   681 SPWKTTKQVLEHWDPLSSPTTSLSVHALP--HS-------APYLHWP-SGPEFDLAKPDPYDLYE 735

  Fly   687 SSRL----------RGIRPFQPIRDFTREDF-----------------ENGPPMSTKQIRSI--- 721
            .||.          |...|..|..:|...:.                 |.|.|:|.|....|
Zfish   736 KSRAIYENRQPGLPRASLPADPSAEFQEVEVHLRRQKSGFGFRILGGEEPGQPVSPKAQEKILIG 800

  Fly   722 TILREIPF-----VVPFNKRVSILQSLVAASKMR-VQGNMQAFLQGPSVLITVRRSHLYEDAYDK 780
            .|:.:.|.     :.|.::.:|:...:||....| |...|....:...|.:||||         :
Zfish   801 AIIEKSPADKDGRLRPGDELISVDGIVVAGKPHRYVIDLMHGAARTGQVKLTVRR---------R 856

  Fly   781 LRPDNEP 787
            ::|..||
Zfish   857 VQPTGEP 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	7/22 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	53/267 (20%)
magi2a	NP_001314782.1	PDZ_signaling	25..100	CDD:238492
		NK	122..286	CDD:302627
		WW	307..337	CDD:238122
		WW	352..381	CDD:278809
		PDZ	431..511	CDD:214570
		PDZ	595..676	CDD:214570	11/59 (19%)
		PDZ	762..856	CDD:214570	20/102 (20%)
		PDZ_signaling	920..1007	CDD:238492
		PDZ_signaling	1182..1262	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900