DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and smurf2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	436	Identity:	136/436 - (31%)
Similarity:	216/436 - (49%)	Gaps:	57/436 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 PPMSTKQIRSITILREIP-----FVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRR 770
            |....:|.:|:.....:|     ..||..||     .||...|:..|...|...|.....|.|.|
Zfish   357 PGQLKEQAQSVVSPGNLPEDPECLTVPKYKR-----DLVQKLKILRQELSQQQPQAGHCRIEVSR 416

  Fly   771 SHLYEDAYD---KLRP-DNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRG 831
            ..::|::|.   |:|| |....|..|||         .|.|:|.|||.||:|..|.....:|..|
Zfish   417 EEIFEESYRQVMKMRPKDLWKRLMVKFR---------GEEGLDYGGVAREWLYLLSHEMLNPYYG 472

  Fly   832 FFMVTTDN--KLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVE----LPLAEFFLTKLAGK 890
            .|..:.|:  .|..||:.| :..::..:::|:|||:|.:::....::    ||    |..:|.||
Zfish   473 LFQYSRDDIYTLQINPDSA-VNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLP----FYKQLLGK 532

  Fly   891 YSDVDIHQLASLDPELYRNLLYLKDYSGDVS-ELNLDFTVASSSLGQTQIVELKPQGQSIPVTNS 954
              .:.:..:.|:||:|:.:|:::.|  .|:: .|:..|.|..::.|:....||||.|:|||||..
Zfish   533 --PITLDDMESVDPDLHNSLVWILD--NDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTQD 593

  Fly   955 NRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLK-- 1017
            .:.||::|..:::....|.....|.:||.:.|:|...|..|..|||::::.|.. .||:.|.|
Zfish   594 TKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLG-KIDINDWKSN 657

  Fly  1018 ---KHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLD----PPFFI 1075
               |||      :|:...:..||..:|.:|:.:|.:||:|||..||.||.|||.|.    |..|.
Zfish   658 TRLKHC------TPDSNIVKWFWRAVESYDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFT 716

  Fly  1076 --QNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
              |.......||.|.||.|.:.:||:::.:::.:|||.||:...||
Zfish   717 IHQIDASTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGF 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	122/376 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	111/348 (32%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028
		WW	159..188	CDD:278809
		WW	252..283	CDD:197736
		WW	298..330	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375		3/17 (18%)
		HECTc	410..762	CDD:238033	120/376 (32%)
		HECTc	437..762	CDD:214523	111/349 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810