DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and nedd4l

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_021324687.1	Gene:	nedd4l / 559634	ZFINID:	ZDB-GENE-051118-2	Length:	1279	Species:	Danio rerio

Alignment Length:	361	Identity:	125/361 - (34%)
Similarity:	205/361 - (56%)	Gaps:	18/361 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   768 VRRSHLYEDAYDKLRPDNEPD-LRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRG 831
            :.|::::|::|.::.....|| |:.:..|:|.|     |.|:|.|||.||:...|.|..|:|..|
Zfish   926 LHRNNIFEESYRRIMSLKRPDSLKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYG 985

  Fly   832 FFMVT-TDN-KLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDV 894
            .|..: ||| .|..|||.....||:..::.||||:.|.::|...|::......|...:.||  .:
Zfish   986 LFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLGK--QI 1048

  Fly   895 DIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEY 959
            .::.:.|:|.|.|.:|.::.:  .|.:||:|.|.:...:.|||..|:|||.|..:.|||.|:.||
Zfish  1049 TLNDMESVDSEYYNSLKWILE--NDPTELDLRFCIDEDNFGQTYQVDLKPSGSDMVVTNDNKKEY 1111

  Fly   960 LQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGG 1024
            :.|:..::...::::..|||.:|.:.::||:.:.:|...||::|:.|.. .:|:.|.::|..|..
Zfish  1112 IDLVIQWRFVNRVQKQMNAFLEGFTELIPIDLIKIFDENELELLMCGLG-DVDVNDWRQHTVYKN 1175

  Fly  1025 EFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL----DPPFF-IQNTGDMERL 1084
            .:.|.||.|..||:.:...|..:|.:||:|||..||.|:.||.:|    .|..| |:..|..::|
Zfish  1176 GYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGTPDKL 1240

  Fly  1085 PTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFE 1120
            |.|.||.|.|.||.::|.|.:|||||.|:::..|||
Zfish  1241 PRAHTCFNRLDLPMYETFEDLREKLLMAVENAQGFE 1276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	123/359 (34%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	118/338 (35%)
nedd4l	XP_021324687.1	C2	<374..430	CDD:326325
		WW	473..499	CDD:306827
		WW	669..698	CDD:306827
		WW	798..829	CDD:197736
		WW	856..885	CDD:238122
		HECTc	946..1275	CDD:214523	118/338 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910