DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and WWC3

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens

Alignment Length:	479	Identity:	108/479 - (22%)
Similarity:	157/479 - (32%)	Gaps:	155/479 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 HTCDRDTVIRKAALERQKR------NELRQKENGAVVLQSYAR--SFIHRQRR------------ 65
            |....:...|:..|.|.||      .||:.||.|...||...|  |..|...:
Human    87 HQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQEIDRKMSSTHTSYKLDEAQAIMSELR 151

  Fly    66 --KRA----EREVFDIYL---------------------MGHKDGIVED---------------- 87
              |:|    |:|..|:..                     ..|..|:..|
Human   152 TIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGVPGDAGVPQQFCDAGSQTDI 216

  Fly    88 ------ESLTFLLRRLNFFYSIREAKDSERLIEVCQQILRQPARLLQHSSPDSLWL----LRLCK 142
                  :..|.|:.|:...:...||:  :|:..:.||:    |||...|.|.:...    |:|.|
Human   217 IGEFVFDDKTRLVDRVRLNWQYEEAR--KRVANIQQQL----ARLDNESWPSTAEADRDRLQLIK 275

  Fly   143 LLDTCL--LQLSLSHTAQAIPL--------RMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIA 197
            ..:..|  |||.::....|..:        |:.|......:.......|.:|.|  |:....|:.
Human   276 EKEALLQELQLIIAQRRSAGDVARLEEERERLEEELRRARATSAQGATERILLQ--EKRNCLLMQ 338

  Fly   198 RNYFVRLRRLLDDKCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFT 262
            .....||...|..:...|...||...|..:...|......|     ||:.|.:||:|      ||
Human   339 LEEATRLTSYLQSQLKSLCASTLTVSSGSSRGSLASSRGSL-----ASSRGSLSSVS------FT 392

  Fly   263 RDILATPHTDP--------LRYFVLPCFALNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFL 319
             ||...|..:.        ||:.::|..:|..|.||            |..|..|.....|||
Human   393 -DIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRDAPF------------SEPPGPSGFHKQRRS-- 442

  Fly   320 FYGVETGHKTTRMDSIFSSFLLNSL----MVLDRRQLATLHQSPLLVIYVRLIAEMM-----PNI 375
               ::|...   :.|:.|...|:||    ..||...|.....|||        |::.     |.:
Human   443 ---LDTPQS---LASLSSRSSLSSLSPPSSPLDTPFLPASRDSPL--------AQLADSCEGPGL 493

  Fly   376 LQLPKSTLRGHANAPHRHRDGDDD 399
            ..|.:  ||.||:|.     ||:|
Human   494 GALDR--LRAHASAM-----GDED 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305	9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		22/93 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		1/1 (100%)
		C2_Kibra	602..725	CDD:176062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900