DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and herc4

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_005173092.1	Gene:	herc4 / 557513	ZFINID:	ZDB-GENE-070801-1	Length:	1052	Species:	Danio rerio

Alignment Length:	717	Identity:	195/717 - (27%)
Similarity:	302/717 - (42%)	Gaps:	152/717 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   492 LYTLA--FTPKFIRAVWFKLAAEST---QLGFSAPLTL---ISKGVVPKH-------QGVDRTIP 541
            :|||:  ...|::.....::.||.|   .|.||:...|   ......|.|       .|||
Zfish   400 IYTLSTELIQKWLNHGLGRIPAEITDEIDLVFSSASCLNGSFLSSSNPDHYSTSSKCSGVD---- 460

  Fly   542 LLATFCMLFGRLLPTLHD------VEFVENKLLLQVHST---INHVRL----------------- 580
             :.|..:||.:|:.|.|.      ...:|..||.::.|:   |..:||
Zfish   461 -INTARLLFHKLIQTDHPQISQIIAASLEKNLLPKLSSSPPDIEALRLYLTLPECPLLCNPNNFT 524

  Fly   581 ---MPFSIAEIIQMSKTLKD----------------ISMGLVELAFPETRSNLANYRKVLGHTEA 626
               :||:.|.:     :|||                :...||||           |::|:.:.
Zfish   525 TLTIPFAKAIV-----SLKDAPIKVLGNWWSRFEPVVFQRLVEL-----------YKEVVVYL-- 571

  Fly   627 DDKKLRHQK--------QIWANLLNVVVFVLNQIHTRDLRLG-FCPEDHWTVTRLDLPLDRPTDL 682
                ||.||        :|:...|:..:.:|..:|:.:.|.| ....|.:.:..||..:|...|.
Zfish   572 ----LRMQKLGIPLSEQRIFTCFLDTSLKLLEILHSVNERAGQIIQYDKFYIHELDELIDIRNDY 632

  Fly   683 PLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQS----- 742
            ......::     |..:.|                  |...|.:.|||.....:.::||:
Zfish   633 ATWFQQQM-----FSVVMD------------------SQVTLCKYPFVFDAQAKTALLQTDAVIQ 674

  Fly   743 -LVAASKMRVQGNMQAFLQG-------PSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVS 799
             .:|..:.:.|.....||.|       |.:::.|||.::..|:.:.||.....|.:...::.||.
Zfish   675 MQMAVDQAQRQNFTSLFLSGGGVESVNPCLILIVRRENVVGDSMEVLRKSKNVDYKKPLKVIFVG 739

  Fly   800 SLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRI 864
                 |..:|.|||.:||...::|....|..|.|....:::|.  ......|||.:. ::.||.:
Zfish   740 -----EEAVDAGGVRKEFFLLIMKELLHPKYGMFRFHEESRLI--WFACKTFEDIDL-FHLIGVV 796

  Fly   865 LGKSIYENLLVEL--PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE--LNL 925
            .|.:||...:|||  |||.:  .||..|...::  .|..|.|::.|:|..|.||:.|..|  ..|
Zfish   797 CGLAIYNLTIVELNFPLALY--KKLLKKTPTLE--DLKELMPDVGRSLQQLLDYTEDDLEETFCL 857

  Fly   926 DFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIE 990
            :||:...:.|.|::|||.|.|..|.|..|||.|::....||..|..:....:||..|...|...:
Zfish   858 NFTITEDNFGATEVVELIPNGTDISVNKSNRQEFVNAYVDYIFNKSVAPQFSAFYAGFHKVCGGK 922

  Fly   991 WLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFV 1055
            .|.:|...|||.::.| ....|.::|:|..||.||:..:||:|..||||.......:::|.|.|:
Zfish   923 VLELFQPSELQAMVIG-NTNYDWKELEKSTEYKGEYWADHPTIKIFWEVFHELPLEKKKQFLLFL 986

  Fly  1056 TSCSRPPLLGFKDLDPPFFIQNT-GDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            |...|.|:||.|.|  ...||.| |..:..|.|.||.|||.||.:.:...|:||||:||:...||
Zfish   987 TGSDRIPILGMKSL--ALVIQPTAGGEQYFPVAHTCFNLLDLPKYTSKNTMQEKLLHAIEHNQGF 1049

  Fly  1120 EL 1121
            .|
Zfish  1050 NL 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	122/358 (34%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	115/335 (34%)
herc4	XP_005173092.1	RCC1	3..49	CDD:278826
		RCC1	52..99	CDD:278826
		RCC1	102..152	CDD:278826
		RCC1	156..205	CDD:278826
		RCC1	208..257	CDD:278826
		RCC1	260..308	CDD:278826
		RCC1	313..377	CDD:278826
		HECTc	704..1049	CDD:238033	121/359 (34%)
		HECTc	730..1049	CDD:214523	114/333 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810