DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and LOC556872

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_021334149.1	Gene:	LOC556872 / 556872	-ID:	-	Length:	1472	Species:	Danio rerio

Alignment Length:	534	Identity:	113/534 - (21%)
Similarity:	180/534 - (33%)	Gaps:	150/534 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RDTVIRKAALERQ----KRNELRQKENGAVVLQSYARSFIHRQRRKRAEREVFDIYLMGHKDGIV 85
            |.|:::|....||    :..:...|.|||.| ||.  ||...||..:...:..::.|:.:: |..
Zfish   734 RQTLVKKVWDHRQCNGLQSGDAVVKINGADV-QSL--SFAQVQRILQEHTKKGEVILLVYR-GPS 794

  Fly    86 EDESLTFLLRRLNFFYSIREAKDSE----RLIEVCQQILRQPARLLQHSSPDSLWLLRLCKLLDT 146
            ...:....:|||. ....|.|.|||    ..:.:.:..|..|:..|..||     |::....||:
Zfish   795 NYSNSPSSVRRLT-PPPPRSASDSEVPFTDSMPLSRNSLTPPSPALVRSS-----LVQSTSFLDS 853

  Fly   147 CLLQLSLSHTAQAIPLRML--ETFTTVSS--VQQYMKDEAVLFQYME--------RVFGFLIAR- 198
            ..:.|:|.      |...:  |...||.|  |:...|::....:..|        ..|||:||.
Zfish   854 VPVTLTLE------PRDWMSSEDGGTVLSPRVKTEEKEQPPALRGYEVELKRKPGEGFGFVIASQ 912

  Fly   199 ------------NYFVRLRR----------LLDDKCPPLDGET-LHAPSPLAEALLQLLLRP--- 237
                        :.||.:||          ...|:...:||.: ::.|.   ..|.|:|.|.
Zfish   913 DVENVKAVSLLPHRFVTVRRGSPAARSGQIRPGDRLEAVDGRSVVNLPH---RELAQILRRAGNT 974

  Fly   238 --LEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLMRSLYD- 299
              |.:..||||.....:......:| .:...:.|..|..||:.:........|.|.|...|.|:
Zfish   975 LRLTIVPRASAHSSERADYDPDYKN-RKTHKSKPKQDATRYYSVELERGPTGFGFSLRGGSEYNM 1038

  Fly   300 -----ALESAGPA---------------ESDSTSS-RRSFLFYGVETGHKTTRMDSIF---SSFL 340
                 .|...|||               ..||.:. ..|.....:.||  .:|:..:|   :.::
Zfish  1039 GLYVLGLMEGGPASRSHKIQVSDQLVEINGDSAAGMTHSQAVEQIRTG--GSRIHLVFKRGNGYV 1101

  Fly   341 LNSLMVLDRRQLATLHQSPL-LVIYVRLIAEMMP-----NILQLPKSTLRG-------------- 385
            .:    .||..:..:..||. |...:..::...|     :.||.|:.|.||
Zfish  1102 PD----YDRDHITAVSSSPQPLQSNLAAVSHHRPQRDATSSLQKPEKTNRGWKEPRERSDGGDRE 1162

  Fly   386 ----------------------------HANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQ 422
                                        ..|.|.||.|.....|:.|....|:........|..:
Zfish  1163 SPARLKGDRQGRRRRSRDDERRRRSYSLPRNTPRRHSDESMKVEKVERNGREMEKGNKRSVDRPK 1227

  Fly   423 TCRTSGELSVKERE 436
              |:..|..|:||:
Zfish  1228 --RSKSEERVRERK 1239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523
LOC556872	XP_021334149.1	PDZ_signaling	24..88	CDD:238492
		NK	111..>190	CDD:327404
		PDZ_signaling	365..440	CDD:238492
		PDZ	722..791	CDD:238080	17/59 (29%)
		PDZ_signaling	893..980	CDD:238492	19/89 (21%)
		PDZ_signaling	1017..1093	CDD:238492	15/77 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900