DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and HERC6

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	682	Identity:	163/682 - (23%)
Similarity:	276/682 - (40%)	Gaps:	128/682 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   503 RAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVDRT----------------------IPLLAT 545
            |:...::|....::.||:|..|.:..:  |.:|...|                      |..:.|
Human   408 RSTEHEMAKSEIRMIFSSPACLTASFL--KKRGTGETTSIDVDLEMARDTFKKLTKKEWISSMIT 470

  Fly   546 FCM---LFGRLLP--TLHDVEFVENKLLLQ----VHSTINHVRL-MPFSIAEIIQMSKT------ 594
            .|:   |. |.||  :.|. |.:...|||.    :|.:.|...| :||:.| :.:|||.
Human   471 TCLEDDLL-RALPCHSPHQ-EALSVFLLLPECPVMHDSKNWKNLVVPFAKA-VCEMSKQSLQVLK 532

  Fly   595 -----LKDISMG-LVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIH 653
                 |::.|:. |:::......|.|.:..|    ||.|...::       .||.::. .|::::
Human   533 KCWAFLQESSLNPLIQMLKAAIISQLLHQTK----TEQDHCNVK-------ALLGMMK-ELHKVN 585

  Fly   654 TRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQI 718
            ..:.||   ||:.:.:..|...|:...|         ||.:.|   ||......|...|:
Human   586 KANCRL---PENTFNINELSNLLNFYID---------RGRQLF---RDNHLIPAETPSPV----- 630

  Fly   719 RSITILREIPFVVPFNKRVSILQSLVAASKMRVQ-GNMQAFL--------------QGPSVLITV 768
                |..:.||:.....::.:||   |.|.:::| ...:|::              ..|..::.|
Human   631 ----IFSDFPFIFNSLSKIKLLQ---ADSHIKMQMSEKKAYMLMHETILQKKDEFPPSPRFILRV 688

  Fly   769 RRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFF 833
            |||.|.:||..:|......|......::|:     :|...:.|||..||...:.:....|..|.|
Human   689 RRSRLVKDALRQLSQAEATDFCKVLVVEFI-----NEICPESGGVSSEFFHCMFEEMTKPEYGMF 748

  Fly   834 MVTTDNKLYPNPNVADLF----EDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLAGKYSDV 894
            |       ||.......|    :..:|.|:..|.:.|.|::...:..||.......||..:...:
Human   749 M-------YPEMGSCMWFPAKPKPEKKRYFLFGMLCGLSLFNLNVANLPFPLALYKKLLDQKPSL 806

  Fly   895 DIHQLASLDPELYRNLL-YLKDYSGDVSE-LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRI 957
            :  .|..|.|.|.::|. .|.|.:.|:.: |.:.|::.    .....|:|.|.|.||||..:|:.
Human   807 E--DLKELSPRLGKSLQEVLDDAADDIGDALCIRFSIH----WDQNDVDLIPNGISIPVDQTNKR 865

  Fly   958 EYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEY 1022
            :|:....||..||.::.....|::|...|...|.|..|..:||...|.| ....|.:..:::.:|
Human   866 DYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG-NTDYDWKQFEQNSKY 929

  Fly  1023 GGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDMERLPTA 1087
            ...:...||:|..||:........::::.|.|:|...|....|.:.::..|....|......||:
Human   930 EQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHARGIQKMEIVFRCPETFSERDHPTS 994

  Fly  1088 STCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            .||.|:|.||.:.|:|:|.|.|..||.:..||
Human   995 ITCHNILSLPKYSTMERMEEALQVAINNNRGF 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	97/360 (27%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	87/336 (26%)
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274
		RCC1_2	89..118	CDD:290274
		RCC1	105..155	CDD:278826
		RCC1	158..208	CDD:278826
		RCC1	215..263	CDD:278826
		RCC1_2	250..279	CDD:290274
		RCC1	266..313	CDD:278826
		HECTc	684..1026	CDD:238033	95/360 (26%)
		HECTc	711..1026	CDD:214523	86/333 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810