DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Wwc2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_598552.2	Gene:	Wwc2 / 52357	MGIID:	1261872	Length:	1187	Species:	Mus musculus

Alignment Length:	907	Identity:	173/907 - (19%)
Similarity:	277/907 - (30%)	Gaps:	341/907 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LERQKRNELRQKENGAVVLQSYARSFIHRQRRKR-------AEREVFDIYLMGHK--------DG 83
            :|::|...:.:||.....||     ||..|:|.:       |||:..:..||..:        :.
Mouse   340 IEKEKLMLINEKEELLKELQ-----FITPQKRSQEELERLEAERQHLEEELMAARGSPSRALTER 399

  Fly    84 IVEDESLTFLLRRLNFFYSIREAKDSERLIEVCQQILRQPARLLQHSSPDSLWLLRLCKLLDTCL 148
            :..:|....||::|.        :.::....:..|:....:..|..||..||.
Mouse   400 LKLEEKRKELLQKLE--------ETTKLTTSLYSQLQSLSSSTLSMSSGSSLG------------ 444

  Fly   149 LQLSLSHTAQAIPLRMLETFTTVSSVQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDK-- 211
               ||:.:..::......:..::||.:.|...:           |..:..:|..:|..||.:|
Mouse   445 ---SLASSRGSLNTSSRGSLNSLSSSELYYSSQ-----------GDQMDTDYQYKLDFLLQEKGG 495

  Fly   212 -CPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLR 275
             .|.....|:|..               ||.|..|..||.....:.|        .|:.||.||.
Mouse   496 YIPSGPITTIHEN---------------EVVKSPSQPGQSGLCGVGV--------TASSHTTPLT 537

  Fly   276 YFVLPCFALNVDFPFDLLMRSLYDALESAG---------PAESDSTS-------------SRRSF 318
            .......:|:        .||...:|...|         |..|..||             |||
Mouse   538 EASKSVASLS--------SRSSLSSLSPPGSPLVLDSVFPGSSHDTSPHQFPTDFEDCELSRR-- 592

  Fly   319 LFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNI-LQLPKST 382
             |..|..|.....:||....   .|..:|:.:.|:....        .|:.|...:: ..|||.
Mouse   593 -FADVGLGENQALLDSDSGG---ASQPLLEDKGLSDCPG--------ELLCEGATDVEKSLPKR- 644

  Fly   383 LRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELS----VKERECLLES-- 441
             ||      .|..||..:..|....:|..|..:..|  |.:.:..||:.    .:|...::|:
Mouse   645 -RG------LHLRGDKTTRVSAAASDESVAGDSGVY--EASMKQPGEMEDVPYSEEDVTIVETAQ 700

  Fly   442 --IAILNETERVDF--IVQQLD-------PHIENTHLIYALCEICHNL--------------MIY 481
              |.:..:|:...|  |:.||.       ||....:...||.....::              ::|
Mouse   701 VQIGLRYDTKSSSFMVIIAQLRNLHAFSIPHSSKVYFRVALLPSSADVSCLFRTKVHPPTESVLY 765

  Fly   482 N-------KHAVFEYKLL--------------------YTLAFTP--KFIRAVWFKL-------- 509
            |       ..|..:.|.|                    .:||..|  ..|..:|:.|
Mouse   766 NDVFRVAVSQAALQQKTLRVDLCSASKHRREECLAGTQISLADLPFSNEIFMLWYNLLPSKQMPC 830

  Fly   510 ----------AAESTQ---------------LGFSAPLTLISKGVV---------PKHQGVDRT- 539
                      .|.|.|               ...||.|..:.:.:.         |:.:|..|.
Mouse   831 KKNEDGNEEPGARSQQPMLDPIDLDAVSALLARTSAELLAVEQELAQEEEEEELRPERRGPGRDC 895

  Fly   540 ------------------IPLL-----------------ATFCMLF-----GRL---LPTLHDV- 560
                              :||.                 .:.|...     |:|   ||||.|.
Mouse   896 LTMLREASDEPAALRESGVPLAEGSRCTEDPKPCPRGPETSQCRKEPAEDPGQLPSGLPTLVDKE 960

  Fly   561 ----EFVENKLLLQV--HSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRK 619
                |.|::.:.::.  .|:::. |..||....:|..|:|..           |..||   .|..
Mouse   961 TNTDEVVDSNMAVRPKDRSSLSS-RQHPFVRNSVIVRSQTFS-----------PGERS---QYIC 1010

  Fly   620 VLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRL-------------GFCPEDHWTVTR 671
            .|..:::|...|..:.          :||.|....|.||:             ..||    ..|.
Mouse  1011 RLNRSDSDSSTLAKKS----------LFVRNSTERRSLRVKRAVCQPTLRRTAQECP----VRTS 1061

  Fly   672 LDLPLDRPTDLPLTHSSR-------LRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILRE 726
            |||.||  ....||..||       |||:|  |.:.:...:...:.||...:..|...:|::
Mouse  1062 LDLELD--LQASLTRQSRLNDELQALRGLR--QKLEELKAQGETDLPPGVLEDERFQKLLKQ 1119

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523
Wwc2	NP_598552.2	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..464		6/40 (15%)
		C2_Kibra	699..822	CDD:176062	20/122 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..849		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..963		13/88 (15%)
		Phage_Nu1	<1088..>1146	CDD:294991	6/34 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900