DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and UBR5

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_056986.2	Gene:	UBR5 / 51366	HGNCID:	16806	Length:	2799	Species:	Homo sapiens

Alignment Length:	1161	Identity:	237/1161 - (20%)
Similarity:	403/1161 - (34%)	Gaps:	385/1161 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 IPLRMLETFTTVSSVQQYMKDEAV-LFQYMERVFGFLIAR-NYFVRLRRLLDDKCPPLDGETLHA 222
            ||..:..|:....::|.|::::.: .:.:|..:.....|: .|...|....|   |......|||
Human  1813 IPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGD---PGHPNHPLHA 1874

  Fly   223 PSPLAE-----ALLQLLLRPLEVAKRA----------SAGGQMSSMSMAVCRNFTRDILATPHTD 272
            ....|.     |..:..||.||..:||          ||.|...:.::::.|:...:     |:|
Human  1875 SQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDE-----HSD 1934

  Fly   273 PLRYFVLP----CFALNVDFPFDLLMRSLYDALESAGPAESDSTSSRRSFLFYGVETGHKTTRMD 333
                 |||    |...:|.:.|..|:                          |.::..::.|.:|
Human  1935 -----VLPVLDVCSLKHVAYVFQALI--------------------------YWIKAMNQQTTLD 1968

  Fly   334 SIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHANAPHRHRDGDD 398
            :          ..|:|::...|                    |:|      |..|....| :.||
Human  1969 T----------PQLERKRTREL--------------------LEL------GIDNEDSEH-ENDD 1996

  Fly   399 DSEES----EDEDEELPAA--------RTLDYDMEQTCRTSGELSVKERECLLESIAILNETERV 451
            |:.:|    :.:|:.|||.        |..|......|.......|.    |.|:|.:.::
Human  1997 DTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVP----LAEAIPLADQ---- 2053

  Fly   452 DFIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVF---EYKLLYTLAFTPKFIRAVWFK---LA 510
                    ||:...:.              .|..:|   ...|..:.|.:.|.:..|...   |.
Human  2054 --------PHLLQPNA--------------RKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLE 2096

  Fly   511 AESTQLGFSAPLTLISKGVV-----PKHQGVDRTI------------------------------ 540
            ...|::.::|.|    |.|:     .|.:|.::.:
Human  2097 VLPTKMSYAANL----KNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIG 2157

  Fly   541 ------PLLATF---CMLFGRLLPTLHDVEFVENKLLLQVHSTI--NHVRLMPFSIAEIIQMSKT 594
                  |.|.:|   |...|.::.  ||:.....:|.|::...:  ..|...|.||
Human  2158 LTESEGPPLTSFRPQCSFMGMVIS--HDMLLGRWRLSLELFGRVFMEDVGAEPGSI--------- 2211

  Fly   595 LKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWANLLNVVV----FVLNQIHTR 655
                   |.||...|.:.  :.:|:.:       :|||:|:   :..|::.|    .:|.|...|
Human  2212 -------LTELGGFEVKE--SKFRREM-------EKLRNQQ---SRDLSLEVDRDRDLLIQQTMR 2257

  Fly   656 DLRLGF---CPEDHWTVTRLDLPL-DRPTD---------------------LPL----------T 685
            .|...|   |......|.|:.:.. |.|.:                     ||.          |
Human  2258 QLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGT 2322

  Fly   686 HSSRLRGIRPFQPIRDFTRE---------------------DFENGPPMSTKQIR--SITILREI 727
            |:|.::.:|. :..||..||                     ||.....:.|:..|  |.....:.
Human  2323 HTSLMQRLRN-RGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDD 2386

  Fly   728 PFVVPFNKRVSILQSLVAASKMRVQGNMQAFLQ---------GPSVLITVRRS------------ 771
            |..:|.::     |:|......|||....||..         .|:.|:.:..|
Human  2387 PEPLPAHR-----QALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAM 2446

  Fly   772 -----HLYEDAYDKLRP----DNEPDLRFKFRIQFVSS-----LGLDEA--GIDGGGVFREFLSE 820
                 |..|:..|.:..    |:...::.:.|.:..||     :.||:.  |.|...:|
Human  2447 ELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLF------ 2505

  Fly   821 LIKTAFDP-NRGFFMVTTDNKLYPNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFL 884
                 :.| .|||:...      |..|.......:..    ||||||..:.:|.|..:.|....:
Human  2506 -----YQPGKRGFYTPR------PGKNTEARLNCFRN----IGRILGLCLLQNELCPITLNRHVI 2555

  Fly   885 TKLAGKYSDVDIHQLASLDPELYRNL--LYLKDYSGDV----SELNLDFTV---ASSSLGQTQIV 940
            ..|.|:  .|:.|..|..||.:|.:|  |.|...|.|.    |.::|.|.:   .....||   |
Human  2556 KVLLGR--KVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQ---V 2615

  Fly   941 ELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILIS 1005
            ||.|.|.:||||..|..||::..|::::.|...:..:|.||||.:|||...|...:.::.::|::
Human  2616 ELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVN 2680

  Fly  1006 GAEIPIDLEDLKKHCEYGGEFSPEHPSIVT----FWEVLEGFDDMQRRQLLKFVTSCSRPPLL-- 1064
            |.. .::::.|.....:..|.......::.    ||.::|.....:|:.|:.|.||....|..
Human  2681 GCG-EVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEE 2744

  Fly  1065 GFKDLD-----PPFFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
            ||:.:.     ||       |.:.||||:||.:.|.:|.:.:.:.:::|||.||::
Human  2745 GFQPMPSITIRPP-------DDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKT 2793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	100/399 (25%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	95/356 (27%)
UBR5	NP_056986.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..175
		CUE_UBR5	184..230	CDD:270606
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..352
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	999..1031
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1052..1075
		ZnF_UBR1	1177..1244	CDD:197698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1318
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1515..1740
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1859..1890		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1984..2021		11/37 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2117..2142		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2323..2392		13/69 (19%)
		PolyA	2389..2452	CDD:197769	11/67 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2473..2493		3/19 (16%)
		HECTc	2501..2796	CDD:214523	88/327 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900