DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and HERC5

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	494	Identity:	127/494 - (25%)
Similarity:	192/494 - (38%)	Gaps:	108/494 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   709 NGPPMSTKQIRSITILREIP----------FVVPFNKRV--------------------SILQSL 743
            :.||....:|  ..:|.|.|          .||||.|.|                    |....|
Human   631 HSPPQEALEI--FFLLPECPMMHISNNWESLVVPFAKVVCKMSDQSSLVLEEYWATLQESTFSKL 693

  Fly   744 VAASKMRV-------------QGNMQAFLQ------------------------------GPSVL 765
            |...|..|             .||:||.|:                              .|:..
Human   694 VQMFKTAVICQLDYWDESAEENGNVQALLEMLKKLHRSKKHKAYLRSAAIEEERESEFALRPTFD 758

  Fly   766 ITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNR 830
            :||||:||.||..::|......|||.:..:.|..     |.|.|.|||.:||...|......|..
Human   759 LTVRRNHLIEDVLNQLSQFENEDLRKELWVSFSG-----EIGYDLGGVKKEFFYCLFAEMIQPEY 818

  Fly   831 GFFMVTTDNKLYPN-------PNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFLTKLA 888
            |.||       ||.       | |...||  :|.|:|.|.:.|.|::...:..||.......||.
Human   819 GMFM-------YPEGASCMWFP-VKPKFE--KKRYFFFGVLCGLSLFNCNVANLPFPLALFKKLL 873

  Fly   889 GKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE--LNLDFTVASSSLGQTQIVELKPQGQSIPV 951
            .:...::  .|..|.|:|.:||..|.|..||..|  ..:.|.| ......|.::   |.|.||.|
Human   874 DQMPSLE--DLKELSPDLGKNLQTLLDDEGDNFEEVFYIHFNV-HWDRNDTNLI---PNGSSITV 932

  Fly   952 TNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDL 1016
            ..:|:.:|:....:|..|..::.....||:|...:...:.:.:|..:||:.:|.| ....|.:..
Human   933 NQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVG-NTDYDWKTF 996

  Fly  1017 KKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPFFIQNTGDM 1081
            :|:..|...::..||:||.||:........::::.|.|:|...|..:....::...|....:.:
Human   997 EKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFLTGTDRLQMKDLNNMKITFCCPESWN- 1060

  Fly  1082 ERLP-TASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
            ||.| .|.||.::|.||.:.|:|.:.|.|..||.:..||
Human  1061 ERDPIRALTCFSVLFLPKYSTMETVEEALQEAINNNRGF 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	104/364 (29%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	93/340 (27%)
HERC5	XP_011530324.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810