DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and hyd

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster

Alignment Length:	1331	Identity:	253/1331 - (19%)
Similarity:	448/1331 - (33%)	Gaps:	455/1331 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 GHKDGIVEDESLTF------LLRR------------LNFFYSIRE---AKDSERLIEVCQQILRQ 122
            |.:||..:|:|..|      |.||            ....::||.   |:.|.|:......:...
  Fly  1712 GSEDGESDDQSDEFNFNEQQLERRSTNSNARSDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFID 1776

  Fly   123 PARLLQHSSPDSLWLLRLCKLLDTCLLQLSLSHTAQA--IPLRMLE------TFTTVSSVQQYMK 179
            |..|.:.:.|.|..:  ....::...:..:.|:.|:|  |.:|.:.      ::..::.::..:|
  Fly  1777 PMALRRSTVPASTTV--TTPSIEPHTMATTASNLARAFGITIRQISELISILSYNVLNDIETSLK 1839

  Fly   180 ---DEAVLFQ-YMERVFGFLIARNYFVRLRRLLDDKCPPLDGETLHAPSPLAEALLQLLLRPLEV 240
               |||:..| ::|:            ||:...|.....:||         .||.|:.
  Fly  1840 IQNDEAIAVQAFVEK------------RLKATWDWMFTVMDG---------TEAQLKF------- 1876

  Fly   241 AKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFALNVDFPFDLLMRSLYDALESAG 305
                  |..:                 |.:|||..    |...||        :.:...:.::..
  Fly  1877 ------GAYL-----------------TNYTDPNH----PLHPLN--------LSAQASSSQTPA 1906

  Fly   306 PAESDS--------TSSRRSFLFY--GVETGHKTTRMDSIFSSFLLNSLMVLD---RRQLATLHQ 357
            ||.|.|        ::|||.|..|  .:...|.:...|         :|.|||   .|.:|.:..
  Fly  1907 PATSSSVNGVNIMGSNSRRDFFTYCLSLMRSHTSEHRD---------ALPVLDITALRHIAYVLD 1962

  Fly   358 SPLLVIYVRLIAEMMPNILQLPKSTLRGHAN--APHRHRDGDDDSEESEDEDEELPAARTLDYDM 420
            :  .|.|:|..:.....     :.|:.|..|  :|         ..||.|.|:||......:.|:
  Fly  1963 A--FVYYMRNDSGFYDK-----QDTISGRINNLSP---------MTESYDTDDELANLEEFNADV 2011

  Fly   421 EQTCRT--SGELSVKERECLLESIAIL----NETERVDFIVQQLDPHIENTHLIYALC---EICH 476
            :.:..:  ||....:.......|.:.|    :..|..:..:....|..:..||:....   |:..
  Fly  2012 QMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFA 2076

  Fly   477 NLMIY------NKHA--------VFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISK 527
            ||.:.      |..|        :|:|        ||              |:||||..|
  Fly  2077 NLPLLVTTNANNSGATNDGDGGSIFDY--------TP--------------TRLGFSNSL----- 2114

  Fly   528 GVVPKHQGVDRTIPL---------------LATFCMLFGRLLPTLHDVEFVENK----------- 566
               .:::.|..|:|:               .:|...::.:|.......:|..:|
  Fly  2115 ---KRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEK 2176

  Fly   567 -LLLQVHSTI---------------------NHVRLMPFSIAE---IIQMSKTLKDISMGLVELA 606
             :|::...::                     |...:.|.:.|.   ::.....||.|.
  Fly  2177 VVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTID------- 2234

  Fly   607 FPETRSNLANY-RKVLGHTEADDKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVT 670
                 |::.|| ...|...|......::||....:||   :|...............|..::.::
  Fly  2235 -----SDINNYSASNLSTAEQAKCDTQYQKSTSDHLL---LFPARGSQFYQSNFSELPSWNFLLS 2291

  Fly   671 RLDLPLDR-----PTDLPLTHSSRLRGIRPFQPIRD--FTR--EDFENG---------------- 710
            |..|.||.     ..|:.:.|.|.|..:|.| |:::  |.|  |...||
  Fly  2292 RWKLTLDLFGRVFMDDVGMEHGSVLPELRGF-PVKEMRFRRHMEKLRNGQQRDLVLCKLERNRES 2355

  Fly   711 ---------------------PPMSTKQIR-----------------------SITILREIP--- 728
                                 ||::..:::                       ::....:||
  Fly  2356 LIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLE 2420

  Fly   729 ----------FVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVL------------------ 765
                      :||||:   |||:|...:...|.|..:|.......:|
  Fly  2421 SVQVGTNHSKYVVPFS---SILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYT 2482

  Fly   766 ----------------ITVRRSHLYEDAYDKLRPDNE---PDLR-FKFRI---QFVSSLGLDEAG 807
                            ::|....:.|..|.|:...|:   |.:. ....|   |.:|.:..||
  Fly  2483 PPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDE-- 2545

  Fly   808 IDGGGVFREFLSELIK-----------------------TAFDPNRGFFMVTTDNK-LYPNPNVA 848
                 ..|:.::|.|:                       ...||      |..||: |:.:|...
  Fly  2546 -----TLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDP------VDDDNEPLFYSPGKR 2599

  Fly   849 DL------FEDYEKHYYF--IGRILGKSIYENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPE 905
            ..      |..:|:...|  |||::|..:.:|.|:.|.|....|..:.|:  .:..|.||..||.
  Fly  2600 GFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGR--KIKFHDLAFFDPA 2662

  Fly   906 LYRNLLYL------KDYSGDVSELNLDFTV---ASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQ 961
            ||.:...:      |:....::.:.|.|.:   .....|..:::   |.|:.:.||:||..||::
  Fly  2663 LYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELI---PGGRDVAVTSSNIFEYVR 2724

  Fly   962 LIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEF 1026
            ...:|:|.....:...|.:.|:.:|||...:...:.::|::|::|.. .|::..|..:..:..|
  Fly  2725 RYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVG-DINVSTLISYTTFNDE- 2787

  Fly  1027 SPEHPSIVT-----FWEVLEGFDDMQRRQLLKFVTSCSRPPLL--GFKDLDPPFFIQNTGDMERL 1084
            |.|.|..:.     ||.::|..:.|:|:.|:.|.|.....|..  ||:.|  |.......|...|
  Fly  2788 SSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL--PSVTIRPADDSHL 2850

  Fly  1085 PTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
            |||:||.:.|.:|.:.:...:|.|:|.||:|
  Fly  2851 PTANTCISRLYIPLYSSKSILRSKMLMAIKS 2881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	97/405 (24%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	91/380 (24%)
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	6/20 (30%)
		PolyA	2498..2561	CDD:197769	14/69 (20%)
		HECTc	2589..2885	CDD:238033	79/302 (26%)
		HECTc	2589..2884	CDD:214523	79/302 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830