DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and ube3c

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_956767.2	Gene:	ube3c / 393445	ZFINID:	ZDB-GENE-040426-1211	Length:	1081	Species:	Danio rerio

Alignment Length:	1155	Identity:	446/1155 - (38%)
Similarity:	681/1155 - (58%)	Gaps:	107/1155 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGFDGEYRRRPVQSLGGASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRR 65
            ||.|:|::||.|..||||||...::.:::.:...||:||.:.|::...|:::|||.|.:..|:::
Zfish     1 MFSFEGDFRRTPKVSLGGASRKEEKASLLHRTQEERRKREDERKRLKNAIIIQSYIRGYQDRKQQ 65

  Fly    66 KRAEREVFDIYLMGHKDG----IVEDESLTFLLRRLNFFYSIREAKDSERLIEVCQQILRQPARL 126
            ...:|..||..:...:.|    :.:...|:.|:|:|.|||.:.|  |..|:|.:||.:::..|:.
Zfish    66 YAIQRGSFDHCVCQCQSGSGPQLTDSAILSQLVRQLLFFYRLSE--DRPRMIWMCQCLVKHHAQF 128

  Fly   127 LQ-HSSPD-SLWLLRLCKLLDTC--LLQLSLSHTAQ-AIPLRMLETFTTVSSVQQYMKDEAVLFQ 186
            :: .:.|: .:.|.::.:||..|  |||.....:.. |:|:||||.|::..:...:::||..:..
Zfish   129 VKLLTGPERQICLFQIKRLLGHCCRLLQSCEDDSLNVAVPMRMLEVFSSERTYLPFLQDENCVTS 193

  Fly   187 YMERVFGFLIARNYFVRLRRLLDDKCPPLDGETLHAPS-PLAEALLQLLLRPLEVAKRASAGGQM 250
            .:|::..:::.:.::..|..|::.|.|. ..|....|| |||:.||:..|:||.....:......
Zfish   194 LIEQILHYMVQKGFYRSLYVLVNHKLPS-SLEYSDTPSIPLAQTLLEHTLKPLHFTYSSCPPDTR 257

  Fly   251 SSMSMAVCRNFTRDILATPHTDPLRYFVLPCFA-LNVDFPFDLLMRSLYDALESAGPAESDSTSS 314
            ..:..|    ||.:.::.|.|:.:.:|.:|..: ..:.|||...:.||...:.|:..|.:.:
Zfish   258 QFVFSA----FTEEFISAPFTEQIYHFFVPALSDPKLAFPFQNFLWSLQATIASSVQARTQA--- 315

  Fly   315 RRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLP 379
              .:|||                 |:|:    :....|::|.:..|| :|:..:..::|   .||
Zfish   316 --PWLFY-----------------FVLS----VGESGLSSLSEEGLL-LYLNALQTLLP---LLP 353

  Fly   380 KSTLRGHANAPHRHRDGDDDSEESEDEDEELPAAR-----TLDYDMEQTCRTSGELSVKERECLL 439
            .:.....|       |.:.|||:.|:...:.|||.     ::.|..|:..:   :|..|:
Zfish   354 VTECNSRA-------DINSDSEDEEEMTVQHPAAPDGSWISVHYITEECVQ---KLDTKQ----- 403

  Fly   440 ESIAILNETERVDFIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYTLAFTPKFIRA 504
            ::.|:|....|        |...|:...:.|  .|||.||:.::..|...:|||:|||..:|:|.
Zfish   404 QTNALLTLVWR--------DSASEDVFTMMA--SICHTLMVQHRMMVPRVRLLYSLAFNARFLRH 458

  Fly   505 VWFKLAAESTQL--GFSAP-LTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPTLHDVEFVENK 566
            :|:.:.:..|::  |...| |.::|:|.....:..:|.|||...|..||...|.::||.||..:.
Zfish   459 LWYLITSMKTKMITGSMVPLLQVMSRGSPMTLEDSNRIIPLFYLFSSLFSHSLISVHDSEFFGSS 523

  Fly   567 LLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSN-----LANYRKVLGHTEA 626
            ...|..|:     :||||:.|::.:|:.|:|..:|:::||:|||::.     :|.:|.|...|.:
Zfish   524 ADGQSQSS-----MMPFSLGELVTLSRCLRDACLGIIKLAYPETKTEHKEEYVAAFRSVGVKTNS 583

  Fly   627 D-DKKLRHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDL------PL 684
            . .::::.|::.|..|..|:..::..:..||:|..|||..||....:::..|:.|.|      .:
Zfish   584 QVQQRIQAQQKRWVQLFKVITNLVKMLKARDIRRPFCPSGHWLSDEVNIRADKVTQLYVPSARHM 648

  Fly   685 THSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKM 749
            ..:.|:..|.|.|...|...|.    ||:|..:.|.:.||.|:||||||.:||.|.|.|:.|.|.
Zfish   649 WRTRRMGRIGPLQSTLDVGLEP----PPLSVSEERHLAILTELPFVVPFEERVKIFQKLIYADKR 709

  Fly   750 RVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVF 814
            .|||. ..||.|  |.:|:||:::||||||||.|:|||||:.:.|:..:::.|||||||||||:|
Zfish   710 EVQGE-GPFLDG--VNVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIF 771

  Fly   815 REFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLF-EDYEKHYYFIGRILGKSIYENLLVELP 878
            ||||:||:|:.|:||:|||..|.:..|||:|....|. |.:.:||||:||||||::|||:|||||
Zfish   772 REFLNELLKSGFNPNQGFFKTTNEGLLYPSPTAEMLVGESFTRHYYFLGRILGKALYENMLVELP 836

  Fly   879 LAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSLGQTQIVELK 943
            .|.|||:||.|..:|||||.|||||||:|||||:||.|.|||.:|.|:|||.::.||:.|:||||
Zfish   837 FASFFLSKLLGTSADVDIHHLASLDPEMYRNLLFLKSYEGDVEDLGLNFTVVNNDLGEAQVVELK 901

  Fly   944 PQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAE 1008
            |.|:.||||.:|||.|:.|:|||:||.|||.||.|||:||:||:.:|||.||..:|:|:|:|||.
Zfish   902 PGGKDIPVTTANRIAYIHLVADYRLNKQIRAHCLAFRQGLANVVNLEWLRMFDQQEIQVLVSGAH 966

  Fly  1009 IPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPF 1073
            :||.|||||:...|.|.:|..||.|..||:|:|.|.|.::|:|||||||||||||||||:|.|.|
Zfish   967 VPICLEDLKRFTNYSGGYSATHPVIKIFWDVVESFSDEEKRKLLKFVTSCSRPPLLGFKELYPAF 1031

  Fly  1074 FIQNTG-DMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
            .|.|.| |:|||||||||.||||||.|...:.||.||||||:|.||||||
Zfish  1032 CIHNGGTDLERLPTASTCMNLLKLPEFCDPQLMRNKLLYAIESSAGFELS 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	220/355 (62%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	204/332 (61%)
ube3c	NP_956767.2	IQ	47..64	CDD:197470	6/16 (38%)
		HECTc	723..1079	CDD:238033	220/355 (62%)
		HECTc	745..1078	CDD:214523	204/332 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595661
Domainoid	1	1.000	391	1.000	Domainoid score	I751
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8783
Inparanoid	1	1.050	728	1.000	Inparanoid score	I604
OMA	1	1.010	-	-		QHG47393
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0005112
OrthoInspector	1	1.000	-	-		oto40284
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1831
SonicParanoid	1	1.000	-	-		X3631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940