DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Herc3

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001102101.1	Gene:	Herc3 / 362377	RGDID:	1307803	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	787	Identity:	190/787 - (24%)
Similarity:	313/787 - (39%)	Gaps:	176/787 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   427 SGELSVKERECLLESIAILNETERVDF-IVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYK 490
            ||:||.:              .:|..: :|:|:....:.|   :.||....|    :..|| :::
  Rat   349 SGQLSAR--------------ADRFKYRVVKQIFSGGDQT---FVLCSTYEN----SSPAV-DFR 391

  Fly   491 LL----YTLAFTPKFIRAVW-FKLAAESTQLGFSAPLTLISKGVV-----------------PKH 533
            .:    ||.....:.| ||| .||...:.....:..:.::|....                 ||.
  Rat   392 TVNQAHYTNLINDETI-AVWRQKLTEHNNANTVNGVVQILSSAACWNGSFLEKKIDEHFKTSPKI 455

  Fly   534 QGVDRTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDI 598
            .|:|                   |:....:..||:...||.|....|..|....|.|:|.:..|:
  Rat   456 PGID-------------------LNSTRVLFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDV 501

  Fly   599 SMGLVELAFPE------------TRSNLA--------NYRKVLGH--TEADDK------------ 629
            ....:.|..||            ....||        |..|||.:  ::|..|
  Rat   502 EAMRIYLILPEFPLLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKSA 566

  Fly   630 ---KLRHQKQ-----IWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTD--LPL 684
               .||.:|.     ::.|.:...:.:|.:::..:|::.....|.:.:..:...:|...|  :..
  Rat   567 VLYLLRGRKTFLIPVLFNNYMTATLKLLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQEDYLMWF 631

  Fly   685 THSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSILQSLVAASKM 749
            .|.|.::. ||                    ..::....|...||:.....:..:||: .|..:|
  Rat   632 LHQSGMKA-RP--------------------SIMQDAVTLCSYPFIFDAQAKTKMLQT-DAELQM 674

  Fly   750 RVQ---GNMQ-AFL---------QGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSL 801
            :|.   .|:| .|:         :.|.:::.|||:||..||..:|...::.||:...::.|..
  Rat   675 QVAVNGANLQNVFMLLTLEPLLARSPFLVLHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDG-- 737

  Fly   802 GLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED--YEKHYYF--IG 862
               |.|:|.|||.:||...|:|...:|..|.|....|:.|.       .|.|  :.:|.:|  ||
  Rat   738 ---EEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLL-------WFSDTCFVEHNWFHLIG 792

  Fly   863 RILGKSIYENLLVEL--PLAEFFLTKLAGKYSDV--DIHQLASLDPELYRNLLYLKDYSG-DVSE 922
            ...|.:||.:.:|:|  |||      |..|..:|  .:..|..|.|...|:|..|.||.| |:.|
  Rat   793 ITCGLAIYNSTVVDLHFPLA------LYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEE 851

  Fly   923 -LNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNV 986
             ..|:|||...|.|..:..:|.|.|..:.|...||.|::....:|...:.:.....||..|...|
  Rat   852 TFCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAYVNYIFQISVHEWYTAFSSGFLKV 916

  Fly   987 LPIEWLYMFSNKELQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQL 1051
            ...:.|.:|...||:.::.| ....:.|:|::...|.|::|..||::..|||....|...::::.
  Rat   917 CGGKVLELFQPAELRAMMVG-NSNYNWEELEETAVYKGDYSSTHPTVKLFWETFHEFPLEKKKRF 980

  Fly  1052 LKFVTSCSRPPLLGFKDLDPPFFIQNTGDME-RLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
            |.|:|...|.|:.|...|.  ..||:|...| .||.|.||.|||.||.:.:.|.|:.:|..|:.:
  Rat   981 LLFLTGSDRIPIYGMASLQ--IVIQSTATGEDYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDN 1043

  Fly  1116 GAGFELS 1122
            ..||.|:
  Rat  1044 YEGFSLA 1050

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	114/364 (31%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	105/341 (31%)
Herc3	NP_001102101.1	ATS1	2..331	CDD:227511
		RCC1	313..377	CDD:395335	8/44 (18%)
		HECTc	702..1048	CDD:238033	114/366 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810