DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Herc6

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_008761185.1	Gene:	Herc6 / 362376	RGDID:	1561739	Length:	1027	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	164/707 - (23%)
Similarity:	279/707 - (39%)	Gaps:	178/707 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 AAESTQLGFSAPLTLISKGVVPKHQG--------------------VDRTIPLLATFC------- 547
            |.....|.||:|..|.:..:..:..|                    .::.|..|.|.|
  Rat   398 AKREISLIFSSPACLTASFLKKRDAGENNFINVDLKLARDVFKMLTAEKWISSLITTCLEETLLR 462

  Fly   548 -----------MLFGRLLPTLHDVEFVEN--KLLLQVHSTINHVR-------------LMPFSIA 586
                       :|...|||....::..:|  .|..:..|.|:.:|             |...|:.
  Rat   463 GLPYSSPHQEALLVFLLLPECSIMQDPKNWKTLAFEFASAIHKMRSKSLTFLRNWWASLEVSSLN 527

  Fly   587 EIIQMSK------------TLKDIS--------MGLVELAFPETRSNLANYRKVLGHTEADDKKL 631
            .::||.|            .:||.|        |..|:....:|.|:|        |.|.
  Rat   528 SLVQMLKKTIVSQLHNEVPMMKDTSNLKVSLEMMKEVQKILEKTNSHL--------HNEV----- 579

  Fly   632 RHQKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPF 696
              .|....:.|.|::.|:.::|..:.:|   ||:.:.:
  Rat   580 --PKMEDTSNLKVLLEVMKEVHEANCQL---PENAFIM--------------------------- 612

  Fly   697 QPIRDFTREDFENGPPMSTKQIRSI----TILREIPFVVPFNKRVSILQ---SLVAASKMRVQGN 754
            ..|.:|..|:    ..|:.:|:..|    .:..:.||::....::.:::   |:..:.:::|..:
  Rat   613 NDIFNFNTEE----GIMAKQQMFFIKYYSMVFNDFPFILDLPSKIILMKHDSSVKLSDEVKVAAS 673

  Fly   755 MQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDEAGIDGGGVFREFLS 819
            .:. :..|..::.||||||.||...:||...:.|||....:.|:     :|...:||||..||..
  Rat   674 PEK-MGCPFFILKVRRSHLVEDTLRQLRQAEDFDLRKTLSVGFI-----NEIRPEGGGVSSEFFH 732

  Fly   820 ELIKTAFDPNRGFFMVTTD--NKLYP-NPNVADLFEDYEKHYYFI-GRILGKSIYENLLV---EL 877
            .:.:...||....||...:  |..:| ||.       :||..||: |.:.|.|: .||.|   ..
  Rat   733 CIFEEMTDPKYEMFMYPENGSNMWFPVNPK-------FEKSRYFLFGILCGLSL-NNLNVINLSF 789

  Fly   878 PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLL-YLKDYSGDVSELNLDFTVASSSLGQTQIVE 941
            ||| .:...|..|.|..|:..|:.|   |.|||. .|...:|.:.||::.|::    ....:.|:
  Rat   790 PLA-LYKKLLEQKPSLEDLKDLSLL---LGRNLQEVLNCEAGVIEELHMYFSI----YWDQRDVD 846

  Fly   942 LKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISG 1006
            |.|.|.|:||..:|:.:|:....||..|:.|:...:.|.:|...|...:.:..|..:||...|.|
  Rat   847 LIPDGISVPVNETNKRDYVSKCVDYIFNISIKTIYDEFHRGFYKVCNRDSIRHFQPEELMAAIIG 911

  Fly  1007 AEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDP 1071
             ....|.:..:.:.:|...:|..||:|:.||:........::::.|.|:|.|.|..:.|
  Rat   912 -NPTCDWKQFENNSKYENGYSKSHPTILLFWKAFHELTLDEKKKFLLFLTGCDRLHVKG------ 969

  Fly  1072 PFFIQNTGDMERL---------PTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGF 1119
               :||.|...|.         |.:.||.::|.||.:.|:.:|:|.|..||.:..||
  Rat   970 ---LQNEGIRFRCPEVFSERDNPRSLTCHSILDLPKYSTMRRMKEALQVAINNNKGF 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	110/371 (30%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	98/347 (28%)
Herc6	XP_008761185.1	RCC1	39..88	CDD:278826
		RCC1	92..141	CDD:278826
		RCC1	144..194	CDD:278826
		RCC1_2	182..210	CDD:290274
		RCC1_2	236..265	CDD:290274
		RCC1	252..299	CDD:278826
		HECTc	682..1023	CDD:238033	108/371 (29%)
		HECTc	706..1023	CDD:214523	98/347 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810