DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Ube3c

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_038964472.1	Gene:	Ube3c / 362294	RGDID:	1559986	Length:	1083	Species:	Rattus norvegicus

Alignment Length:	1164	Identity:	447/1164 - (38%)
Similarity:	674/1164 - (57%)	Gaps:	123/1164 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFGFDGEYRRRPVQSLGGASHTCDRDTVIRKAALERQKRNELRQKENGAVVLQSYARSFIHRQRR 65
            ||.|:|:::.||..||||||...::.:::.:...||:||.|.|::...||::||:.|.:..|:::
  Rat     1 MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAVIIQSFIRGYRDRKQQ 65

  Fly    66 KRAEREVFDIYLMGHKDG----IVEDESLTFLLRRLNFFYSIREAKDSERLIEVCQQILRQPARL 126
            ...:|..||......:.|    |.:..:||.|:|:|.|||  ::::||:|||.:.|       .|
  Rat    66 YFTQRSAFDQCADSAQPGGTFRIADGPALTLLVRQLLFFY--KQSEDSKRLIWLYQ-------NL 121

  Fly   127 LQHSSPDSLWLLRLCKLLD-----TCLLQLS---------LSHTAQ-----AIPLRMLETFTTVS 172
            ::|||       ...|.||     |||.||.         |.:.:.     |:|:||||.|::.:
  Rat   122 IKHSS-------LFVKQLDGSERLTCLFQLKRLMSLCCRLLQNCSDDSLNVALPMRMLEVFSSEN 179

  Fly   173 SVQQYMKDEAVLFQYMERVFGFLIARNYFVRLRRLLDDKCPPLDGETLHAPSPLAEALLQLLLRP 237
            :....::|.:.:...:|::..:::...|:..|..|::.|.|.....:..:..|:|:.||:.:|:|
  Rat   180 TYLPVLQDSSYVVSVIEQILHYMVHSGYYRSLYLLINSKLPSSIEYSDLSRVPMAKTLLENVLKP 244

  Fly   238 LEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTDPLRYFVLPCFA-LNVDFPFDLLMRSLYDAL 301
            |.....:...|....:..|    ||.:.|..|.||.:.:|::|..| ....||::..:.:|. .|
  Rat   245 LHFTYSSCPEGARHQVFSA----FTEEFLGAPFTDQIYHFIIPALADTQTVFPYEPFLNALL-LL 304

  Fly   302 ESAGPAESDSTSSRRSFLFYGVETGHKTTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVR 366
            ||    .|...||...:|||.|                     :.:....|..|.:..||| |:|
  Rat   305 ES----RSSKRSSGVPWLFYFV---------------------LTIGENYLGALSEDGLLV-YLR 343

  Fly   367 LIAEMMPNILQLPKSTLRGHANAPHRHRDGDDDSEESEDEDEELPAARTLDYDMEQTCRTSGELS 431
            ::...:.   |||.|..  ....|....|.:||:||::                :.|....|.:|
  Rat   344 VLQTFLS---QLPASPT--GVGRPDPTSDSEDDNEETD----------------QPTSPEDGRVS 387

  Fly   432 VK--ERECLLESIAILNETERVDFIVQQLDPHIENTHLIYALCEICHNLMIYNKHAVFEYKLLYT 494
            ..  ..|||.:    |:..::.:.::..:.....:..:...:..|||.||:.::..|.:.:|||:
  Rat   388 APYITEECLRK----LDTKQQTNTLLNLVWRDSASEEVFTRMASICHTLMVQHRMMVPKVRLLYS 448

  Fly   495 LAFTPKFIRAVWFKLAAESTQL--GFSAP-LTLISKGVVPKHQGVDRTIPLLATFCMLFGRLLPT 556
            |||..:|:|.:||.:::.:||:  |...| |.:||:|.....:...|.|||...|..||...|.:
  Rat   449 LAFNARFLRHLWFLISSMTTQMITGSMVPLLQVISRGSPMSFEDSSRIIPLFYLFSSLFSHSLIS 513

  Fly   557 LHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPET----RSNLANY 617
            :||.||..:.:.:.....::   :|||::.|:|.:|:.|:|..:|:::||:|||    |....:.
  Rat   514 IHDNEFFGDPIEVVGQRQLS---MMPFTLEELILLSRCLRDACLGIIKLAYPETKPEVREEYVSA 575

  Fly   618 RKVLGHTEADDKKLRH----QKQIWANLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDR 678
            .:.:|.|  .:.:::|    :::.|..|..|:..::..:.:||.|..|||.:||...:.|:..|:
  Rat   576 FQSIGVT--TNSEMQHCIQMEQKRWVQLFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADK 638

  Fly   679 PTDL--PLT-HSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSIL 740
            .|.|  |.: |..|.|.:....|::.......|: ||:|..:.|.:.||.|:||||||.:||.|.
  Rat   639 VTQLYVPASRHVWRFRRMGRIGPLQSTLEVGLES-PPLSVSEERQLAILTELPFVVPFEERVKIF 702

  Fly   741 QSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYDKLRPDNEPDLRFKFRIQFVSSLGLDE 805
            |.|:.|.|..|||: ..||.|  :.:|:||:::||||||||.|:|||||:.:.|:..:::.||||
  Rat   703 QRLIYADKQEVQGD-GPFLDG--INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDE 764

  Fly   806 AGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED-YEKHYYFIGRILGKSI 869
            |||||||:|||||:||:|:.|:||:|||..|.:..|||||....|..| :.:||||:||:|||::
  Rat   765 AGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKAL 829

  Fly   870 YENLLVELPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLDFTVASSSL 934
            |||:|||||.|.|||:||.|..:|||||.|||||||:|:|||:||.|..||.||.|:|||.::.|
  Rat   830 YENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEEDVEELGLNFTVVNNDL 894

  Fly   935 GQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKE 999
            |:.|:||||..|:.||||.:|||.|:.|:|||:||.|||.||.|||:||:||:.:|||.||..:|
  Rat   895 GEAQVVELKFGGKDIPVTGANRIAYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLRMFDQQE 959

  Fly  1000 LQILISGAEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLL 1064
            :|:|||||::|:.|||||....|.|.:|.:||.|..||.|:|||.|.::|:||||||||||||||
  Rat   960 IQVLISGAQVPVSLEDLKSFTNYSGGYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLL 1024

  Fly  1065 GFKDLDPPFFIQNTG-DMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
            |||:|.|.|.|.|.| |:|||||||||.||||||.|.....:|.||||||:..||||||
  Rat  1025 GFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDEALLRSKLLYAIECAAGFELS 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	217/355 (61%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	201/332 (61%)
Ube3c	XP_038964472.1	IQ	47..64	CDD:197470	6/16 (38%)
Ube3c	XP_038964472.1	HECTc	725..1081	CDD:238033	217/355 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353529
Domainoid	1	1.000	382	1.000	Domainoid score	I797
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8783
Inparanoid	1	1.050	673	1.000	Inparanoid score	I700
OMA	1	1.010	-	-		QHG47393
OrthoDB	1	1.010	-	-		D1163565at2759
OrthoFinder	1	1.000	-	-		FOG0005112
OrthoInspector	1	1.000	-	-		oto98008
orthoMCL	1	0.900	-	-		OOG6_100865
Panther	1	1.100	-	-	LDO	PTHR45700
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3631
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910