DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and Hace1

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	XP_006256657.1	Gene:	Hace1 / 361866	RGDID:	1306114	Length:	916	Species:	Rattus norvegicus

Alignment Length:	838	Identity:	202/838 - (24%)
Similarity:	341/838 - (40%)	Gaps:	209/838 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 DYDME----QT-----CRTSGELSVKERECLLESIAILNETERVDFIVQQLDPHIENTHLIYALC 472
            |.|:|    ||     |:...:.:|   :|||:|.|.:|.            |::.....:|..|
  Rat   156 DVDVEDAMGQTALHVACQNGHKTTV---QCLLDSGADINR------------PNVAGATPLYFAC 205

  Fly   473 EICHNLMIYNKHAVFEYKLLYTLAFTPKFIRAVWFKLAAESTQLGFSAPLTLISKGVVPKHQGVD 537
            .       :.:....:..||....:.|              .:.|.: ||.|..:|      |..
  Rat   206 S-------HGQRDTAQILLLRGAKYLP--------------DKNGVT-PLDLCVQG------GYG 242

  Fly   538 RTIPLLATFCMLFGRLLPTLHDVEFVENKLLLQVHSTINHVRLMPFSIAEIIQMSKT--LKDISM 600
            :|..:|..:   ..||..|:  |:..:|:.|.:     |.:|.:   :..:.|.|::  || |..
  Rat   243 QTCEVLIQY---HPRLFQTI--VQMTQNEDLRE-----NMLRQV---LQHLSQQSESQYLK-ILT 293

  Fly   601 GLVELAFPETRSNLANYRKVLGHT---EADDKKLRHQKQIWANLLNV------------------ 644
            ||.|:|.......|:.:|.|...:   ||..|.|....:|:.::..:
  Rat   294 GLAEVATTNGHKLLSVFRLVSSLSSSYEAQMKSLLRIVRIFCHVFRIGPSSPSNGMDMGYNGNKT 358

  Fly   645 ---VVFVLNQIHTRDLRLGFCPEDHWTV-TRLDLPLDRPTDLPLT--------HSSRLRGIRPFQ 697
               .||       :.|.|.:...|.|.| ...:|..::.....:|        .......|..|:
  Rat   359 PRSQVF-------KPLELLWHSLDEWLVLIATELMKNKEDSADITSILLKQKGQDQEASCISAFE 416

  Fly   698 PIRDFTREDFENGPPMS--------------TKQIRSITILR--------------EIP------ 728
            |....:.|....||..|              .:.:.|:|..|              ::|
  Rat   417 PPGPGSYERLSTGPGESKPDVLAGKQEASADCQDVISVTANRLSAVIQAFYMCCSCQMPPGMTSP 481

  Fly   729 -FVVPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVL---ITVRRSHLYEDA----YDKL---- 781
             |:....|...:|:..|..:...:..:....|:.|.::   :.:.::..::|.    |:.|
  Rat   482 RFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQ 546

  Fly   782 -------RPDNEPDLR-------FKFRIQFVSSLGL------------DEAGIDGGGVFREFLSE 820
                   ||.:|.|:.       |:...:.||....            .|.|: |.||.||:...
  Rat   547 PDSDMVHRPVSENDILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGM-GQGVVREWFDI 610

  Fly   821 LIKTAFDPNRGFFMVTTDNKLY-PNPNVADLFEDYEKHYYFIGRILGKSIYENLLVELPLAEFFL 884
            |.....:|:...|..:.|...: ||.| :.:..|:..::.|.|:|||.::....||.:.....|.
  Rat   611 LSNEIVNPDYALFTQSADGTTFQPNSN-SYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFY 674

  Fly   885 TKLAG---KYSDVDIHQLASLDPELYRNLLYLKDYSGDVSELNLD--FTVASSSLGQTQIVELKP 944
            ..:.|   .|.||     ||:|||..:||.::.|  .|:|:|.|:  |:|.:...|..:.|.|||
  Rat   675 KHILGIPVNYQDV-----ASIDPEYAKNLQWILD--NDISDLGLELTFSVETDVFGAMEEVPLKP 732

  Fly   945 QGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISGAEI 1009
            .|.||.||.:|:.||:||:.:.::...|:...|||.:|....:|...:.:|...||::|:||  :
  Rat   733 GGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSG--M 795

  Fly  1010 P-IDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLDPPF 1073
            | ||:.|..|:.||...:..|.|.|..||||:|.....:|..||:|||..||.|..||.::....
  Rat   796 PEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDMTQEERVLLLQFVTGSSRVPHGGFANIMGGS 860

  Fly  1074 FIQN--------TGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGA-GFELS 1122
            .:||        |.::  |||:|||.|:||||.:.:.|.::::||.|:..|: |:.::
  Rat   861 GLQNFTIAAVPYTPNL--LPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	124/403 (31%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	117/365 (32%)
Hace1	XP_006256657.1	ANK repeat	66..95	CDD:293786
		ANK	66..93	CDD:197603
		Ank_2	69..194	CDD:289560	13/52 (25%)
		ANK	92..217	CDD:238125	16/82 (20%)
		ANK repeat	97..128	CDD:293786
		ANK repeat	130..161	CDD:293786	2/4 (50%)
		Ank_2	135..222	CDD:289560	18/87 (21%)
		ANK repeat	163..194	CDD:293786	10/45 (22%)
		ANK repeat	196..221	CDD:293786	4/31 (13%)
		Ank_4	199..249	CDD:290365	12/77 (16%)
		HECTc	561..910	CDD:238033	115/361 (32%)
		HECTc	586..909	CDD:214523	112/335 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810