DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3356 and Hecw2

DIOPT Version :10

Sequence 1:NP_611896.1 Gene:CG3356 / 37876 FlyBaseID:FBgn0034989 Length:1122 Species:Drosophila melanogaster
Sequence 2:NP_001001883.1 Gene:Hecw2 / 329152 MGIID:2685817 Length:1578 Species:Mus musculus


Alignment Length:461 Identity:134/461 - (29%)
Similarity:216/461 - (46%) Gaps:71/461 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   675 PLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSI 739
            |:..|.:.|.|..:..|...|:       :.|||       .::|:.                  
Mouse  1174 PVSSPQNSPGTQRANARAPAPY-------KRDFE-------AKLRNF------------------ 1206

  Fly   740 LQSLVAASKMRVQGNMQAFLQGPSVL-ITVRRSHLYEDAYDKLRPDNEPDL-RFKFRIQFVSSLG 802
                  ..|:..:|    :.|||..| :.:||.||.|||::::...:..|| |.|..:.||.   
Mouse  1207 ------YRKLETKG----YGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG--- 1258

  Fly   803 LDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED-YEKHYYFIGRILG 866
              |.|:|..|..|||...:.:..|:|..|.|..:.::......:....|.| :.:.:.|.|||||
Mouse  1259 --EEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILG 1321

  Fly   867 KSIYENLLVEL----PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE-LNLD 926
            .::....|::.    |..:..|..|.      |:..|..||.|.:::|.::||  .|:.: |:|.
Mouse  1322 LALIHQYLLDAFFTRPFYKALLRILC------DLSDLEYLDEEFHQSLQWMKD--NDIHDILDLT 1378

  Fly   927 FTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEW 991
            |||.....||....||||.|.:||||..|:.||::.:..:::...:.:...:..:|...|:....
Mouse  1379 FTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARL 1443

  Fly   992 LYMFSNKELQILISG-AEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFV 1055
            :.:|..:||:::|:| ||  |||.|.:.:.||.|.:...|..|..||..:|.|::.||.:||:||
Mouse  1444 VSVFDARELELVIAGTAE--IDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFV 1506

  Fly  1056 TSCSRPPLLGFKDL---DPP--FFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
            |..|..|..||..|   :.|  |.::..|.:..||.|.||.|.|.|||:.:...:.||||.|::.
Mouse  1507 TGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1571

  Fly  1116 GAGFEL 1121
            .:.|.|
Mouse  1572 TSTFGL 1577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3356NP_611896.1 HECTc 766..1120 CDD:238033 116/366 (32%)
Hecw2NP_001001883.1 HECW_N 45..162 CDD:465177
C2_NEDL1-like 185..320 CDD:176073
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..453
DMP1 <344..700 CDD:462128
NESP55 <463..639 CDD:115071
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..802
Interaction with TP73. /evidence=ECO:0000250 737..1074
WW 815..844 CDD:459800
HECW1_helix 921..987 CDD:465766
WW 993..1024 CDD:197736
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1030..1075
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1167..1193 5/18 (28%)
HECTc 1222..1576 CDD:238033 117/368 (32%)
Blue background indicates that the domain is not in the aligned region.

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