DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3356 and CG42797

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_572574.2	Gene:	CG42797 / 31905	FlyBaseID:	FBgn0261931	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	1059	Identity:	252/1059 - (23%)
Similarity:	383/1059 - (36%)	Gaps:	274/1059 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 LDDKCPPLDGETLHAPSPLAEALLQLLLRPLEVAKRASAGGQMSSMSMAVCRNFTRDILATPHTD 272
            |.|..|| ...|.|...|     .|.||:.:.....|.|.|..:. |..||.       .||...
  Fly   482 LQDAVPP-GTPTFHGQRP-----QQRLLKRVGGGAGAGATGGATG-SPLVCP-------PTPTHH 532

  Fly   273 PLRYFVLPCFALNVDFPFDLLMRSLYDALESAG--PAESDSTSSRRSFLFY---GVETGHK---- 328
            ..|:..|.....|             .:|.|.|  |::..:.||:..:::.   |.|.|.:
  Fly   533 ARRHARLQAVTAN-------------SSLASGGAIPSDPPAVSSQLDYIYLQDGGQEQGQEQSDE 584

  Fly   329 -----TTRMDSIFSSFLLNSLMVLDRRQLATLHQSPLLVIYVRLIAEMMPNILQLPKSTLRGHAN 388
                 :||:.||            ..|..|....:........|   |.|....:..|:..|.|.
  Fly   585 VVHISSTRLPSI------------PERSAAAAAAAAAAAAGAAL---MEPGTGTVSGSSGAGAAG 634

  Fly   389 APHRHRDGDDDSEESEDEDEELPAARTLDYD-------MEQTCRT----------SGELSVKE-- 434
            .|                  .||.|.....|       ::.|.||          ||..:.:|
  Fly   635 EP------------------PLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQH 681

  Fly   435 -RECL---LESI--AILNET-------------ERVDFIVQQLDPHIENTH-LIYALC-----EI 474
             |:.|   .:||  .|.||:             ...:.......|.....| .|..||     .:
  Fly   682 HRQQLDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDFYSL 746

  Fly   475 CHN----LMIYNKHAVFEYKLLYTLAFTPKFIRAVWFK--------LAAESTQLGFSAPLTLISK 527
            .|.    |.|||::|..::.::......|.|.|..:.|        .|..|.:|.......|...
  Fly   747 LHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELPSCWETKLDQS 811

  Fly   528 G----VVPKHQGVDRTIPLLATFC--------------MLFGRLLPTLHDVEFVENKLLLQVHST 574
            |    :..:|:......|.|...|              ...|...|.|.|...:.        :|
  Fly   812 GKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDLVDGNCLS--------AT 868

  Fly   575 INHVRLMPFSIAEIIQMSKTLKDISMGLVELAFPETRSNLANYRKVLGHTEADDKKLRHQKQIWA 639
            ..|:...|.|...             |:..|..|...|:.::.|...||        .|.    .
  Fly   869 SGHINASPASSVS-------------GVPPLPPPRPSSSSSSSRSSHGH--------GHN----C 908

  Fly   640 NLLNVVVFVLNQIHTRDLRLGFCPEDHWTVTRLDLPLDRPTDLPLTHSSRLRGIRPFQPIRDFTR 704
            |..:.:...||...:.....|...... |....:       |:|:.::.::........|.:..|
  Fly   909 NTTSAISCALNADRSAYGAAGMASAGA-TAAGYE-------DVPIAYNEKVIAFLRQPNILEILR 965

  Fly   705 EDFENGPPMSTKQIR-SITILR-------------------------EIPFVVPFNKRVSILQSL 743
            |  ..|....::|:| .|.|||                         ||...||..:| |...|.
  Fly   966 E--RQGQHTMSRQLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEER-SPQGSP 1027

  Fly   744 VAASKM----------RVQGNMQAFL---------QGPSVL-ITVRRSHLYEDAYDKLRPDNEPD 788
            |..|:|          ..:..:::|.         |||..| :.:|||||.|||:.::...|:.|
  Fly  1028 VLNSRMPQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKKD 1092

  Fly   789 LRFKFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDN----KLYPNPNVAD 849
            |: :.|:   :.|...|.|:|.||..|||...|.:..|:|..|.|..:.::    ::.|.....|
  Fly  1093 LQ-RGRL---AVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLSAFVD 1153

  Fly   850 LFEDYEKHYYFIGRILGKSIYENLLVELPLAEFF-------LTKLAGKYSDVDIHQLASLDPELY 907
            ...|:   :.|.||:||.::....|::    .||       |.:|....||     |.|||.|.:
  Fly  1154 NCHDW---FRFSGRVLGLALVHQYLLD----AFFTRPFYKALLRLPVALSD-----LESLDNEFH 1206

  Fly   908 RNLLYLKDYS-GDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQ 971
            ::|.:::|.. |...:|.|.|.|....||.....||||.|::|.:...|:.|||:.:..::|...
  Fly  1207 QSLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIKWRLERG 1271

  Fly   972 IRRHCNAFRKGLSNVLPIEWLYMFSNKELQILISG-AEIPIDLEDLKKHCEYGGEFSPEHPSIVT 1035
            ::....:..:|...|:....:.:|..:||:::|:| ||  ||..|.:.:.||...:...|..||.
  Fly  1272 VQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAE--IDTNDWRLNTEYRSGYHDNHQVIVW 1334

  Fly  1036 FWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDL-----DPPFFIQNTGDMERLPTASTCTNLLK 1095
            ||:|:|.|.:.||.:||:|||..|..|..||..|     ...|.|:..|....||.|.||.|.|.
  Fly  1335 FWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEKWGKPNALPRAHTCFNRLD 1399

  Fly  1096 LPPFKTVEQMREKLLYAIQ 1114
            |||:.|.|.:.||||.|::
  Fly  1400 LPPYPTPELLYEKLLLAVE 1418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	120/367 (33%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	111/345 (32%)
CG42797	NP_572574.2	WW	638..667	CDD:278809	7/28 (25%)
		HECTc	1068..1424	CDD:238033	121/369 (33%)
		HECTc	1092..1423	CDD:214523	111/345 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740