DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Hecw2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001101688.1	Gene:	Hecw2 / 316395	RGDID:	1593244	Length:	1578	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	134/461 - (29%)
Similarity:	216/461 - (46%)	Gaps:	71/461 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   675 PLDRPTDLPLTHSSRLRGIRPFQPIRDFTREDFENGPPMSTKQIRSITILREIPFVVPFNKRVSI 739
            |:..|.:.|.|..:..|...|:       :.|||       .::|:.
  Rat  1174 PVSSPQNSPGTQRANARAPAPY-------KRDFE-------AKLRNF------------------ 1206

  Fly   740 LQSLVAASKMRVQGNMQAFLQGPSVL-ITVRRSHLYEDAYDKLRPDNEPDL-RFKFRIQFVSSLG 802
                  ..|:..:|    :.|||..| :.:||.||.|||::::...:..|| |.|..:.||.
  Rat  1207 ------YRKLETKG----YGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVG--- 1258

  Fly   803 LDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFED-YEKHYYFIGRILG 866
              |.|:|..|..|||...:.:..|:|..|.|..:.::......:....|.| :.:.:.|.|||||
  Rat  1259 --EEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILG 1321

  Fly   867 KSIYENLLVEL----PLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYLKDYSGDVSE-LNLD 926
            .::....|::.    |..:..|..|.      |:..|..||.|.:::|.::||  .|:.: |:|.
  Rat  1322 LALIHQYLLDAFFTRPFYKALLRILC------DLSDLEYLDEEFHQSLQWMKD--NDIHDILDLT 1378

  Fly   927 FTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNAFRKGLSNVLPIEW 991
            |||.....||....||||.|.:||||..|:.||::.:..:::...:.:...:..:|...|:....
  Rat  1379 FTVNEEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARL 1443

  Fly   992 LYMFSNKELQILISG-AEIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFV 1055
            :.:|..:||:::|:| ||  |||.|.:.:.||.|.:...|..|..||..:|.|::.||.:||:||
  Rat  1444 VSVFDARELELVIAGTAE--IDLNDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFV 1506

  Fly  1056 TSCSRPPLLGFKDL---DPP--FFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQS 1115
            |..|..|..||..|   :.|  |.::..|.:..||.|.||.|.|.|||:.:...:.||||.|::.
  Rat  1507 TGTSSIPYEGFASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1571

  Fly  1116 GAGFEL 1121
            .:.|.|
  Rat  1572 TSTFGL 1577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	116/366 (32%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	109/343 (32%)
Hecw2	NP_001101688.1	HECW_N	45..162	CDD:406866
		C2_NEDL1-like	185..321	CDD:176073
		MDN1	<396..741	CDD:227596
		NESP55	<464..632	CDD:115071
		WW	815..844	CDD:395320
		HECW1_helix	921..987	CDD:408233
		WW	993..1024	CDD:197736
		HECTc	1222..1576	CDD:238033	117/368 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810