DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3356 and Smurf2

DIOPT Version :9

Sequence 1:	NP_611896.1	Gene:	CG3356 / 37876	FlyBaseID:	FBgn0034989	Length:	1122	Species:	Drosophila melanogaster
Sequence 2:	NP_001100531.1	Gene:	Smurf2 / 303614	RGDID:	1310067	Length:	748	Species:	Rattus norvegicus

Alignment Length:	412	Identity:	138/412 - (33%)
Similarity:	210/412 - (50%)	Gaps:	54/412 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   731 VPFNKRVSILQSLVAASKMRVQGNMQAFLQGPSVLITVRRSHLYEDAYD---KLRP-DNEPDLRF 791
            ||..||     .||...|:..|...|...|.....|.|.|..::|::|.   |:|| |....|..
  Rat   365 VPRYKR-----DLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMI 424

  Fly   792 KFRIQFVSSLGLDEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDN--KLYPNPNVADLFEDY 854
            |||         .|.|:|.|||.||:|..|.....:|..|.|..:.|:  .|..||:.| :..::
  Rat   425 KFR---------GEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSA-VNPEH 479

  Fly   855 EKHYYFIGRILGKSIYENLLVE----LPLAEFFLTKLAGKYSDVDIHQLASLDPELYRNLLYL-- 913
            ..:::|:|||:|.:::....::    ||    |..:|.||...:|..:|  :||:|:.:|:::
  Rat   480 LSYFHFVGRIMGMAVFHGHYIDGGFTLP----FYKQLLGKSITLDDMEL--VDPDLHNSLVWILE 538

  Fly   914 KDYSGDVSELNLDFTVASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRRHCNA 978
            .|.:|   .|:..|.|..::.|:....||||.|:|||||..|:.||::|..:::....|.....|
  Rat   539 NDITG---VLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLA 600

  Fly   979 FRKGLSNVLPIEWLYMFSNKELQILISGAEIPIDLEDLK-----KHCEYGGEFSPEHPSIVTFWE 1038
            .:||.:.|:|...|..|..|||:::|.|.. .||:.|.|     |||      :|:...:..||:
  Rat   601 LQKGFNEVIPQHLLKTFDEKELELIICGLG-KIDVSDWKANTRLKHC------TPDSNVVKWFWK 658

  Fly  1039 VLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLD----PPFFIQNTGD--MERLPTASTCTNLLKLP 1097
            .:|.||:.:|.:||:|||..||.||.|||.|.    |..|..:..|  ...||.|.||.|.:.:|
  Rat   659 AVELFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIP 723

  Fly  1098 PFKTVEQMREKLLYAIQSGAGF 1119
            |:::.|::.||||.||:...||
  Rat   724 PYESYEKLYEKLLTAIEETCGF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3356	NP_611896.1	HECTc	766..1120	CDD:238033	128/377 (34%)
CG3356	NP_611896.1	HECTc	788..1119	CDD:214523	117/349 (34%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028
		PRP40	155..>236	CDD:227435
		WW	159..188	CDD:395320
		WW	252..283	CDD:197736
		WW	298..330	CDD:197736
		HECTc	393..745	CDD:238033	126/377 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910